{"id":"transdermal-megace","safety":{"commonSideEffects":[{"rate":null,"effect":"Weight gain"},{"rate":null,"effect":"Vaginal bleeding or spotting"},{"rate":null,"effect":"Thromboembolic events"},{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Adrenal insufficiency"}]},"_chembl":{"chemblId":"CHEMBL1201139","moleculeType":"Small molecule","molecularWeight":"384.52"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Megestrol acetate is a synthetic progestin derivative that acts as an appetite stimulant and anabolic agent. It increases appetite through central nervous system effects and promotes weight gain and lean body mass accumulation. The transdermal formulation delivers the drug through the skin to provide sustained systemic exposure for appetite stimulation and nutritional support.","oneSentence":"Megestrol acetate is a progestin that stimulates appetite and promotes weight gain by acting on the hypothalamus and increasing food intake.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:44.289Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cancer-related cachexia and anorexia"},{"name":"HIV/AIDS-related wasting syndrome"},{"name":"Appetite stimulation in patients with advanced malignancy"}]},"trialDetails":[{"nctId":"NCT00163072","phase":"PHASE4","title":"Pharmacokinetics and Safety of Transdermal Megestrol Acetate","status":"WITHDRAWN","sponsor":"Milton S. Hershey Medical Center","startDate":"2005-10","conditions":"Cachexia","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"transdermal Megace","genericName":"transdermal Megace","companyName":"Milton S. Hershey Medical Center","companyId":"milton-s-hershey-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Megestrol acetate is a progestin that stimulates appetite and promotes weight gain by acting on the hypothalamus and increasing food intake. Used for Cancer-related cachexia and anorexia, HIV/AIDS-related wasting syndrome, Appetite stimulation in patients with advanced malignancy.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}