{"id":"transdermal-glucosamine-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or rash at application site"},{"rate":null,"effect":"Local itching or burning"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Glucosamine is an aminomonosaccharide that serves as a precursor for glycosaminoglycans and proteoglycans, key structural components of cartilage. When applied topically, it is intended to penetrate the skin and reach affected joints, where it may stimulate cartilage synthesis and reduce degradation. The transdermal formulation aims to provide localized delivery while potentially reducing systemic exposure compared to oral glucosamine.","oneSentence":"Transdermal glucosamine cream delivers glucosamine through the skin to support cartilage structure and reduce joint inflammation.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:13:38.717Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Osteoarthritis pain and joint support"}]},"trialDetails":[{"nctId":"NCT03743896","phase":"PHASE4","title":"Transdermal Delivery of Glucosamine to the Synovial Fluid of Male and Female With Knee Osteoarthritis","status":"COMPLETED","sponsor":"Lynk Biotechnologies Pte Ltd","startDate":"2016-05-18","conditions":"Osteoarthritis, Knee","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TGC® Plus Capsaicin"],"phase":"marketed","status":"active","brandName":"Transdermal Glucosamine Cream","genericName":"Transdermal Glucosamine Cream","companyName":"Lynk Biotechnologies Pte Ltd","companyId":"lynk-biotechnologies-pte-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Transdermal glucosamine cream delivers glucosamine through the skin to support cartilage structure and reduce joint inflammation. Used for Osteoarthritis pain and joint support.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}