{"id":"transdermal-fentanyl-patch","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Constipation"},{"rate":"20-30","effect":"Nausea"},{"rate":"15-25","effect":"Dizziness"},{"rate":"15-25","effect":"Somnolence"},{"rate":"10-15","effect":"Headache"},{"rate":"10-20","effect":"Application site reactions"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Dependence/withdrawal"}]},"_chembl":{"chemblId":"CHEMBL1201159","moleculeType":"Small molecule","molecularWeight":"372.94"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fentanyl is a potent synthetic opioid agonist that binds to mu-opioid receptors throughout the brain and spinal cord. The transdermal patch formulation provides sustained-release delivery over 48-72 hours, maintaining steady-state plasma concentrations and providing continuous analgesia. 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