{"id":"tranexamic-acid-txa","safety":{"commonSideEffects":[{"rate":null,"effect":"Thromboembolic events (deep vein thrombosis, pulmonary embolism)"},{"rate":null,"effect":"Gastrointestinal disturbances (nausea, vomiting, diarrhea)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Visual disturbances"},{"rate":null,"effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tranexamic acid is a competitive inhibitor of plasminogen and plasmin, enzymes responsible for dissolving fibrin in blood clots. By preventing the conversion of plasminogen to plasmin, it reduces fibrinolysis (clot breakdown) and helps maintain hemostasis. This mechanism makes it useful in conditions characterized by excessive bleeding or fibrinolysis.","oneSentence":"Tranexamic acid inhibits the breakdown of blood clots by blocking plasminogen activation, thereby reducing fibrinolysis and promoting clot stability.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:44.045Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Excessive bleeding or hemorrhage (perioperative and trauma settings)"},{"name":"Menorrhagia (heavy menstrual bleeding)"},{"name":"Hemophilia and other bleeding disorders"},{"name":"Prevention of thromboembolic complications"}]},"trialDetails":[{"nctId":"NCT03540368","phase":"NA","title":"Tranexamic Acid for The Treatment of Gastrointestinal Bleeding","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2018-07-01","conditions":"Gastrointestinal Bleeding","enrollment":48},{"nctId":"NCT07494032","phase":"NA","title":"Extended Oral Tranexamic Acid After Primary Total 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Angioectasias","enrollment":40},{"nctId":"NCT06208267","phase":"NA","title":"Tranexamic Acid Use on Pain, Mobility and Bleeding Following Total Hip and Total Knee Arthroplasty","status":"RECRUITING","sponsor":"St. Mary's Research Center, Canada","startDate":"2025-08-20","conditions":"Postoperative Bleeding","enrollment":210},{"nctId":"NCT03063892","phase":"PHASE4","title":"Effect of Tranexamic Acid (TXA) on Reduction of Postoperative Blood Transfusion","status":"RECRUITING","sponsor":"Gregory M Georgiadis MD","startDate":"2017-08-30","conditions":"Hip Fractures","enrollment":200},{"nctId":"NCT04910464","phase":"PHASE3","title":"Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis","status":"RECRUITING","sponsor":"Assiut University","startDate":"2021-06-05","conditions":"Sepsis","enrollment":80},{"nctId":"NCT06820177","phase":"PHASE4","title":"Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding 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Hematoma","status":"NOT_YET_RECRUITING","sponsor":"Unity Health Toronto","startDate":"2025-09-30","conditions":"Subdural Hematoma","enrollment":130},{"nctId":"NCT07034560","phase":"PHASE4","title":"Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Thammasat University","startDate":"2024-11-12","conditions":"Melasma, Treatment Outcome, Recurrence","enrollment":75},{"nctId":"NCT07013812","phase":"PHASE4","title":"Tranexamic Acid to Reduce Blood Loss in Women Having Planned Cesarean Section","status":"COMPLETED","sponsor":"Combined Military Hospital Multan","startDate":"2023-11-01","conditions":"Cesarean Section, Blood Loss During Surgery","enrollment":68},{"nctId":"NCT07002749","phase":"PHASE1","title":"ROLE OF PROPHYLACTIC TRANEXAMIC ACID IN PREVENTION OF POST-PARTUM HEMORRHAGE IN ELLSCS","status":"NOT_YET_RECRUITING","sponsor":"Patel Hospital, Pakistan","startDate":"2025-06-01","conditions":"Post Partum Hemorrhage","enrollment":104},{"nctId":"NCT04347122","phase":"PHASE4","title":"Tranexamic Acid in Radical Resection and Endoprosthetic Reconstruction","status":"TERMINATED","sponsor":"University of Kansas Medical Center","startDate":"2020-01-28","conditions":"Musculoskeletal Cancer, Sarcoma,Soft Tissue","enrollment":12},{"nctId":"NCT03553186","phase":"PHASE3","title":"Tranexamic Acid in Adult Spinal Deformity Surgery","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2018-07-11","conditions":"Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical","enrollment":100},{"nctId":"NCT06718751","phase":"PHASE2","title":"Tranexamic Acid Therapy For The Treatment of Subdural Hematomas","status":"NOT_YET_RECRUITING","sponsor":"Baylor College of Medicine","startDate":"2025-10","conditions":"Chronic Subdural Hematoma","enrollment":240},{"nctId":"NCT06648265","phase":"PHASE4","title":"EFFECTS OF TRANEXAMIC ACID IN TUMESCENT SOLUTION FOR LIPOSUCTION PROCEDURES","status":"COMPLETED","sponsor":"Total Definer Research Group","startDate":"2022-01-20","conditions":"Liposuction, Bruising, Inflammation","enrollment":78},{"nctId":"NCT06657924","phase":"PHASE2","title":"Preoperative Tranexamic Acid (TXA) to Prevent Bleeding in Patients Undergoing Major Colorectal Surgery","status":"RECRUITING","sponsor":"Kristen Ban","startDate":"2025-02-11","conditions":"Bleeding, Colorectal Disorders, Thromboembolism","enrollment":394},{"nctId":"NCT02314988","phase":"PHASE2, PHASE3","title":"Tranexamic Acid to Reduce Blood Loss in Spine Surgery","status":"RECRUITING","sponsor":"Columbia University","startDate":"2020-06-15","conditions":"Spinal Injuries, Spinal Deformity","enrollment":252},{"nctId":"NCT05774717","phase":"PHASE1","title":"Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis","status":"RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2023-04-01","conditions":"Surgery, Postoperative Blood Loss","enrollment":60},{"nctId":"NCT06920264","phase":"PHASE1","title":"Effect of Tranexamic Acid (TXA) Administered Prior to Shoulder Arthroscopy on Postoperative Pain Medication Usage: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"St. Louis Joint Replacement Institute","startDate":"2021-07-01","conditions":"This Study Will Evaluate Whether TXA Reduces Pain","enrollment":165},{"nctId":"NCT04797156","phase":"EARLY_PHASE1","title":"Combined IV and Topical TXA in Major Spine Surgery","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2021-03-03","conditions":"Spine Surgery, Back Pain","enrollment":65},{"nctId":"NCT05357079","phase":"EARLY_PHASE1","title":"Impact of Topical Tranexamic Acid on Pre- and Post-operative Hemoglobin/Hematocrit","status":"COMPLETED","sponsor":"University of 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