{"id":"tranexamic-acid-oral-short-arm","safety":{"commonSideEffects":[{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Thrombotic events (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tranexamic acid is an antifibrinolytic agent that competitively inhibits plasminogen activation and plasmin activity. By reducing the breakdown of fibrin clots, it helps maintain hemostasis and reduce bleeding. This mechanism makes it useful in conditions characterized by excessive fibrinolysis or bleeding.","oneSentence":"Tranexamic acid inhibits the conversion of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:43.907Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of blood loss in patients undergoing surgical procedures"},{"name":"Treatment of heavy menstrual bleeding"},{"name":"Prevention and treatment of bleeding in hemophilia patients"}]},"trialDetails":[{"nctId":"NCT06894719","phase":"PHASE4","title":"Oral Tranexamic Acid After Total Knee Arthroplasty","status":"NOT_YET_RECRUITING","sponsor":"Rush University Medical Center","startDate":"2026-06-01","conditions":"Total Knee Arthroplasty","enrollment":351},{"nctId":"NCT02288923","phase":"NA","title":"Trial to Compare Femoral Nerve Block With Local Anaesthetic Injection for Post-operative Pain After Knee Replacement.","status":"COMPLETED","sponsor":"Royal Devon and Exeter NHS Foundation Trust","startDate":"2015-03","conditions":"Arthritis Knee","enrollment":199}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"tranexamic acid Oral-Short Arm","genericName":"tranexamic acid Oral-Short Arm","companyName":"Rush University Medical Center","companyId":"rush-university-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranexamic acid inhibits the conversion of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability. Used for Reduction of blood loss in patients undergoing surgical procedures, Treatment of heavy menstrual bleeding, Prevention and treatment of bleeding in hemophilia patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}