{"id":"tranexamic-acid-intravenous-administration","safety":{"commonSideEffects":[{"rate":null,"effect":"Thromboembolic events (deep vein thrombosis, pulmonary embolism)"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Visual disturbances"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tranexamic acid is an antifibrinolytic agent that competitively inhibits the binding of plasminogen and plasmin to fibrin. By blocking fibrinolysis, it stabilizes formed blood clots and reduces excessive bleeding. It is commonly used to reduce blood loss in surgical procedures and manage bleeding disorders.","oneSentence":"Tranexamic acid inhibits the activation of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:43.887Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of blood loss in surgical procedures"},{"name":"Treatment of excessive bleeding in hemophilia and other bleeding disorders"},{"name":"Prevention and treatment of hemorrhage in trauma patients"}]},"trialDetails":[{"nctId":"NCT06337838","phase":"PHASE3","title":"Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial","status":"RECRUITING","sponsor":"Hamilton Health Sciences Corporation","startDate":"2025-06-09","conditions":"Chronic Kidney Diseases, Acute Kidney Injury, Bleeding","enrollment":100},{"nctId":"NCT06229483","phase":"PHASE3","title":"The Effects of Intraoperative Tranexamic Acid on Perioperative Bleeding In Craniotomies","status":"RECRUITING","sponsor":"Stephen Lownie","startDate":"2024-04-03","conditions":"Brain Tumor, Bleeding","enrollment":102},{"nctId":"NCT07474077","phase":"PHASE3","title":"Investigating the Efficacy of Tranexamic Acid as a Prophylactic Agent in Reducing Postpartum Hemorrhage Among Patients Undergoing Cesarean Section in SQUH","status":"NOT_YET_RECRUITING","sponsor":"Sultan Qaboos University","startDate":"2026-05-01","conditions":"Post Partum Haemorrhage","enrollment":88},{"nctId":"NCT07460518","phase":"PHASE4","title":"Tranexamic Acid for Bleeding Reduction During TURP Surgery","status":"NOT_YET_RECRUITING","sponsor":"Hamza Najout","startDate":"2026-03-15","conditions":"Benign Prostatic Hyperplasia, Transurethral Resection of the Prostate, Perioperative Bleeding","enrollment":80},{"nctId":"NCT07432737","phase":"NA","title":"One Versus Two Doses of Tranexamic Acid in Surgically Treated Extracapsular Hip Fractures","status":"RECRUITING","sponsor":"University Hospital for Surgical Diseases St. Naum Ohridsk i- Skopje","startDate":"2026-02-17","conditions":"Hip Fractures","enrollment":120},{"nctId":"NCT05836831","phase":"PHASE4","title":"Indian Trial of Tranexamic Acid in Spontaneous Intracerebral Haemorrhage","status":"RECRUITING","sponsor":"Christian Medical College and Hospital, Ludhiana, India","startDate":"2022-08-30","conditions":"Intracerebral Hemorrhagic Stroke","enrollment":3400},{"nctId":"NCT03849443","phase":"EARLY_PHASE1","title":"Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid Patients at High Risk for Blood Transfusion After Spine Surgery","status":"RECRUITING","sponsor":"Rush University Medical Center","startDate":"2019-08-26","conditions":"Open Posterior Thoracolumbar Spinal Fusion Procedure","enrollment":604},{"nctId":"NCT07314424","phase":"PHASE4","title":"The Effect of Preoperative Intravenous Ferric Derisomaltose and EPO and Tranexamic Acid in Patients With Preoperative Anemia or Iron Deficiency in Bone Tumor","status":"NOT_YET_RECRUITING","sponsor":"Tang Xiaodong","startDate":"2026-01-01","conditions":"Anemia","enrollment":160},{"nctId":"NCT07127042","phase":"PHASE2","title":"Study on BT-114143 Reducing Perioperative Bleeding in Total Knee Arthroplasty（TKA）","status":"RECRUITING","sponsor":"ScinnoHub Pharmaceutical Co., Ltd.","startDate":"2025-08-27","conditions":"Total Knee Arthroplasty","enrollment":270},{"nctId":"NCT07261930","phase":"PHASE4","title":"Effectiveness of Tranexamic Acid in Reducing Blood Loss During Femoral Nail Surgery","status":"COMPLETED","sponsor":"Masaka Regional Referral Hospital","startDate":"2018-10-01","conditions":"Femoral Fractures, Hemorrhage, Surgical, Tranexamic Acid Use","enrollment":43},{"nctId":"NCT05945680","phase":"PHASE4","title":"Tranexamic Acid in Breast Esthetic Surgery.","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2023-09-15","conditions":"Hemorrhage, Bleeding","enrollment":60},{"nctId":"NCT06086444","phase":"PHASE4","title":"Tranexamic Acid in Abdominoplasty.","status":"COMPLETED","sponsor":"Poznan University of Medical Sciences","startDate":"2023-10-17","conditions":"Abdominal Wall Defect, Hemorrhage, Bleeding","enrollment":60},{"nctId":"NCT07187258","phase":"PHASE4","title":"the Use of Tranexamic Acid to Prevent the Bleeding in Bariatric Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-07-01","conditions":"Haemorrhage, Bariatric Surgery Candidate","enrollment":132},{"nctId":"NCT04562610","phase":"PHASE2, PHASE3","title":"Enhanced Recovery After Surgery in Orthopaedic Spine Surgery","status":"COMPLETED","sponsor":"University of California, Davis","startDate":"2020-11-18","conditions":"Lumbar Surgery","enrollment":33},{"nctId":"NCT04910464","phase":"PHASE3","title":"Early Tranexamic Acid and Modulating the Inflammatory Response in Sepsis","status":"RECRUITING","sponsor":"Assiut University","startDate":"2021-06-05","conditions":"Sepsis","enrollment":80},{"nctId":"NCT07094399","phase":"","title":"Tranexamic Acid for Postpartum Vaginal Laceration Hemorrhage","status":"COMPLETED","sponsor":"Harran University","startDate":"2024-01-01","conditions":"Postpartum Hemorrhage, Vaginal Lacerations","enrollment":161},{"nctId":"NCT04117243","phase":"PHASE2","title":"Tranexamic Acid Versus Sublingual Misoprostol in Reducing Blood Loss During Elective CS in High Risk Cases","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-01-20","conditions":"Post Partum Hemorrhage","enrollment":345},{"nctId":"NCT04785651","phase":"NA","title":"Evaluation of the Use of Tranexamic Acid in Tibial Osteotomies","status":"TERMINATED","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2021-02-22","conditions":"Monocompartimental Tibiofemoral Osteoarthritis, Osteoarthritis","enrollment":49},{"nctId":"NCT05713630","phase":"PHASE3","title":"The Use of Tranexamic Acid in the Treatment of Symptomatic Subdural Hematoma","status":"NOT_YET_RECRUITING","sponsor":"Unity Health Toronto","startDate":"2025-09-30","conditions":"Subdural Hematoma","enrollment":130},{"nctId":"NCT06425614","phase":"NA","title":"COmbined pLaTelet and eRythrocyte AutotransfusioN During Cardiac surgEry (COLTRANE) Trial","status":"RECRUITING","sponsor":"University Hospital, Bordeaux","startDate":"2024-07-15","conditions":"On-pump Cardiac Surgery, High Risk for Bleeding, Autotransfusion","enrollment":570},{"nctId":"NCT05811676","phase":"PHASE3","title":"Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Pregnant Women With Placenta Previa","status":"COMPLETED","sponsor":"Guangzhou Medical University","startDate":"2023-07-12","conditions":"Hemorrhage, Postpartum, Placenta Previa","enrollment":1732},{"nctId":"NCT05899465","phase":"PHASE3","title":"Perioperative Treatment With Tranexamic Acid in Melanoma","status":"RECRUITING","sponsor":"University of Aarhus","startDate":"2023-08-25","conditions":"Melanoma","enrollment":1204},{"nctId":"NCT06881628","phase":"PHASE4","title":"Tranxemic Acid and Vitamin K Injection to Control Upper Gastrointestinal Bleeding in Cirrhotic Patients","status":"RECRUITING","sponsor":"Tanta University","startDate":"2024-12-02","conditions":"Upper Gastrointestinal Bleeding (UGIB), Variceal Bleeding, Cirrhosis","enrollment":194},{"nctId":"NCT06754371","phase":"PHASE4","title":"Prophylactic Tranexamic Acid Reduces Postpartum Hemorrhage","status":"RECRUITING","sponsor":"RenJi Hospital","startDate":"2025-01-06","conditions":"Postpartum Hemorrhage, Systemic Autoimmune Diseases","enrollment":276},{"nctId":"NCT04595786","phase":"NA","title":"The Safety of Intravenous Tranexamic Acid in Patients Undergoing Supratentorial Meningiomas Resection","status":"COMPLETED","sponsor":"Beijing Tiantan Hospital","startDate":"2020-10-30","conditions":"Seizures, Meningioma","enrollment":228},{"nctId":"NCT06023212","phase":"PHASE1, PHASE2","title":"Tranexamic Acid Use for Bleeding Prevention in the Surgical Treatment of Metastatic Spinal Tumor in Lung Cancer Patients","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2023-12-01","conditions":"Metastasis Spinal Tumor","enrollment":150},{"nctId":"NCT06493227","phase":"NA","title":"Extended Perioperative Administration of Fibrinolysis Inhibitors After Cardiac Surgery","status":"RECRUITING","sponsor":"Saint Petersburg State University, Russia","startDate":"2024-08-01","conditions":"Thoracic Surgery, Heart Diseases, Fibrinolysis Shutdown","enrollment":1373},{"nctId":"NCT06760078","phase":"PHASE4","title":"Tranexamic Acid with Intensive Blood Pressure Management in Ultra-Early Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"Xuanwu Hospital, Beijing","startDate":"2024-12-31","conditions":"Spontaneous Intracranial Hemorrhage, Hypertension","enrollment":532},{"nctId":"NCT06684080","phase":"NA","title":"The Effectiveness of a Care Bundle to Prevent Postpartum Hemorrhage After Cesarean Delivery","status":"NOT_YET_RECRUITING","sponsor":"Dunjin Chen","startDate":"2025-01-01","conditions":"Cesarean Delivery","enrollment":52000},{"nctId":"NCT05474027","phase":"PHASE4","title":"Reducing Hypotensive Anesthesia Use with TXA During Orthognathic Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"University of Alabama at Birmingham","startDate":"2022-11-11","conditions":"Hypotension During Surgery, Blood Loss, Surgical","enrollment":50},{"nctId":"NCT05806346","phase":"NA","title":"Goal-directed vs. Empirical Tranexamic Acid Administrationin Cardiovascular Surgery","status":"RECRUITING","sponsor":"Konkuk University Medical Center","startDate":"2023-08-01","conditions":"Heart Diseases, Vascular Diseases, Transfusion Related Complication","enrollment":764},{"nctId":"NCT06728670","phase":"NA","title":"Pharmacokinetic Study of Tranexamic Acid","status":"RECRUITING","sponsor":"Zhejiang Cancer Hospital","startDate":"2024-11-20","conditions":"Ovarian Neoplasm Epithelial","enrollment":30},{"nctId":"NCT05994989","phase":"","title":"Two Different Tranexamic Acid Regimens in Coronary Artery Bypass Surgery","status":"COMPLETED","sponsor":"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","startDate":"2023-08-14","conditions":"Postoperative Hemorrhage","enrollment":90},{"nctId":"NCT06710327","phase":"PHASE4","title":"Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Aquablation","status":"NOT_YET_RECRUITING","sponsor":"Kaiser Permanente","startDate":"2025-01","conditions":"Benign Prostatic Hyperplasia","enrollment":56},{"nctId":"NCT06604325","phase":"NA","title":"Prophylactic Tranexamic Acid To Reduce Blood Loss During Caesarean Delivery.","status":"RECRUITING","sponsor":"Aligarh Muslim University","startDate":"2024-10-01","conditions":"Post Partum Hemorrhage","enrollment":300},{"nctId":"NCT06414031","phase":"PHASE3","title":"Tranexamic Acid for Reduction of Transfusion in Abdominal Surgery","status":"RECRUITING","sponsor":"Ulrich Ronellenfitsch, MD","startDate":"2024-06-17","conditions":"Surgical Blood Loss, Transfusion-dependent Anemia, Abdomen Disease","enrollment":850},{"nctId":"NCT06638749","phase":"PHASE3","title":"Effect of TXA on Blood Loss in Reverse Total Shoulder Arthroplasty","status":"WITHDRAWN","sponsor":"University of Kansas Medical Center","startDate":"2019-05-01","conditions":"Shoulder Arthritis, Blood Loss, Surgical, Tranexamic Acid Adverse Reaction","enrollment":""},{"nctId":"NCT06622564","phase":"PHASE3","title":"Decreasing Postoperative Blood Loss and Seizures by Timing of Intravenous Tranexamic Acid 2 Pilot Trial","status":"NOT_YET_RECRUITING","sponsor":"Hamilton Health Sciences Corporation","startDate":"2025-01-01","conditions":"Bleeding, Surgical Blood Loss, Seizures","enrollment":40},{"nctId":"NCT06587620","phase":"NA","title":"Tranexamic Acid Versus Dexmedetomidine for Improving Surgical Field Quality During Spine Surgeries","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2023-12-01","conditions":"Surgical Field Quality Improvement in Spine Surgeries","enrollment":78},{"nctId":"NCT06515535","phase":"NA","title":"Efficacy of Topical Tranexamic Acid in Reducing Blood Loss During CS in Patients With Placenta Previa","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2024-07-24","conditions":"Placenta Previa","enrollment":56},{"nctId":"NCT06060327","phase":"NA","title":"Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-10-15","conditions":"Postpartum Hemorrhage, Blood Loss, Postoperative, Cesarean Section Complications","enrollment":440},{"nctId":"NCT02606045","phase":"PHASE3","title":"Minimize Menorrhagia in Women With Von Willebrand Disease","status":"TERMINATED","sponsor":"Margaret Ragni","startDate":"2019-02-07","conditions":"Von Willebrand Diseases","enrollment":39},{"nctId":"NCT04814433","phase":"PHASE4","title":"Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation","status":"TERMINATED","sponsor":"NYU Langone Health","startDate":"2021-03-24","conditions":"Opioid Pain Medication","enrollment":46},{"nctId":"NCT03517098","phase":"NA","title":"Enhanced Recovery After Surgery (ERAS) Pathway for Primary Hip and Knee Arthroplasty","status":"COMPLETED","sponsor":"West China Hospital","startDate":"2021-02-01","conditions":"Arthroplasty, Replacement, Hip, Knee","enrollment":640},{"nctId":"NCT06301204","phase":"NA","title":"Effectiveness Of Tranexamic Acıd Application Wıth Different Doses On Bleeding, Edema And Physician Comfort In Orthognathıc Surgery Patients","status":"COMPLETED","sponsor":"Bezmialem Vakif University","startDate":"2022-03-01","conditions":"Tranexamic Acid, Orthognathic Surgery, Edema","enrollment":60},{"nctId":"NCT02503319","phase":"PHASE3","title":"Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH (TRANOXY2015)","status":"WITHDRAWN","sponsor":"Azienda U.S.L. 1 di Massa e Carrara","startDate":"2016-01","conditions":"Postpartum Hemorrhage","enrollment":""},{"nctId":"NCT02775773","phase":"PHASE3","title":"Clinical Study to Assess the Equivalence of Tranexamic Acid vs Oxytocin in Reducing the PPH","status":"COMPLETED","sponsor":"Azienda U.S.L. 1 di Massa e Carrara","startDate":"2018-01-30","conditions":"Post Partum Haemorrhage","enrollment":256},{"nctId":"NCT03780894","phase":"PHASE1, PHASE2","title":"Transfusion of Red Blood Cells, Tranexamic Acid and Fibrinogen Concentrate for Severe Trauma Hemorrhage at Pre-hospital Phase of Care.","status":"COMPLETED","sponsor":"Banc de Sang i Teixits","startDate":"2018-11-21","conditions":"Polytrauma, Traumatic Hemorrhage","enrollment":79},{"nctId":"NCT03954314","phase":"PHASE3","title":"DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery","status":"TERMINATED","sponsor":"Population Health Research Institute","startDate":"2019-09-17","conditions":"Bleeding, Surgical Blood Loss, Seizures","enrollment":3242},{"nctId":"NCT05429580","phase":"NA","title":"Prophylactic Tranexamic Acid Use After Vaginal Delivery","status":"COMPLETED","sponsor":"Sanliurfa Mehmet Akif Inan Education and Research Hospital","startDate":"2021-09-01","conditions":"Postpartum Hemorrhage, Vaginal Delivery, Prophylactic Tranexamic Acid Use","enrollment":480},{"nctId":"NCT06149091","phase":"EARLY_PHASE1","title":"Control of Iatrogenic Endobronchial Bleeding by Tranexamic Acid, Adrenalin and Hemagglutinase","status":"UNKNOWN","sponsor":"China-Japan Friendship Hospital","startDate":"2023-12-01","conditions":"Iatrogenic Endobronchial Bleeding","enrollment":300},{"nctId":"NCT06038981","phase":"NA","title":"Assessment of the Impact of Perioperative Administration of Tranexamic Acid on Bleeding After Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Medical University of Gdansk","startDate":"2022-07-04","conditions":"Hemorrhage, Surgical, Bariatric Surgery, Tranexamic Acid","enrollment":300},{"nctId":"NCT06040853","phase":"PHASE4","title":"Postoperative Pain in Laparoscopic Radical Prostatectomy Surgery With Tranexamic Acid: Analgesia? Hiperalgesia?","status":"UNKNOWN","sponsor":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","startDate":"2023-09-30","conditions":"Pharmacological Action","enrollment":90},{"nctId":"NCT05947435","phase":"NA","title":"Tranexamic Acid in Percutaneous Nephrolithotomy","status":"COMPLETED","sponsor":"Haseki Training and Research Hospital","startDate":"2022-01-01","conditions":"Percutaneous Nephrolithotomy, Intraoperative Use of Tranexamic Acid","enrollment":75},{"nctId":"NCT04443920","phase":"PHASE4","title":"Tranexamic Acid for Total Knee Arthroscopy","status":"COMPLETED","sponsor":"The Miriam Hospital","startDate":"2019-10-29","conditions":"Blood Loss, Surgical","enrollment":86},{"nctId":"NCT05874583","phase":"NA","title":"Prevention of Bleeding in Total Joint Replacement: Combined Route Administration of Tranexamic Acid","status":"COMPLETED","sponsor":"Mongi Slim Hospital","startDate":"2021-12-01","conditions":"Tranexamic Acid, Arthroplasty, Replacement, Knee, Blood Transfusion","enrollment":100},{"nctId":"NCT04274335","phase":"PHASE2","title":"Pharmacokinetics and Pharmacodynamics of Tranexamic Acid in Women Having Caesarean Section Birth [WOMAN-PharmacoTXA]","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2020-12-18","conditions":"Pregnancy, High Risk","enrollment":120},{"nctId":"NCT05489185","phase":"PHASE4","title":"Clinical Trial to Assess the Efficacy of Tranexamic Acid in Reducing Blood Loss in Hip Fracture Patients.","status":"UNKNOWN","sponsor":"Biogipuzkoa Health Research Institute","startDate":"2023-05-30","conditions":"Hip Fractures","enrollment":644},{"nctId":"NCT05248321","phase":"NA","title":"Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding","status":"COMPLETED","sponsor":"National Cheng-Kung University Hospital","startDate":"2022-03-24","conditions":"Peptic Ulcer Hemorrhage","enrollment":60},{"nctId":"NCT03085394","phase":"PHASE3","title":"Preoperative Hexakapron Reduces Bleeding in Bariatric Surgery","status":"TERMINATED","sponsor":"Sheba Medical Center","startDate":"2017-09-01","conditions":"Intra-Operative Injury - Other, Post Operative Hemorrhage, Tranexamic Acid","enrollment":152},{"nctId":"NCT03364491","phase":"PHASE3","title":"Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean","status":"COMPLETED","sponsor":"The George Washington University Biostatistics Center","startDate":"2018-03-15","conditions":"Obstetrical Complications, Hemorrhage, Labor and Delivery","enrollment":11000},{"nctId":"NCT05708690","phase":"PHASE4","title":"Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2022-10-01","conditions":"Coronary Artery Disease, Valvular Heart Disease, Surgical Blood Loss","enrollment":132},{"nctId":"NCT02187120","phase":"PHASE3","title":"Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)","status":"COMPLETED","sponsor":"Monash University","startDate":"2014-07-28","conditions":"Wounds and Injuries, Acute Coagulopathy","enrollment":1310},{"nctId":"NCT05696951","phase":"NA","title":"Tranexamic Acid in Sleeve Gastrectomy","status":"COMPLETED","sponsor":"Goztepe Prof Dr Suleyman Yalcın City Hospital","startDate":"2022-01-01","conditions":"Tranexamic Acid Adverse Reaction","enrollment":200},{"nctId":"NCT05340205","phase":"PHASE4","title":"Blood Loss During Cesarean Delivery in Placenta Previa Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-05-04","conditions":"Placenta Previa","enrollment":81},{"nctId":"NCT04691362","phase":"PHASE4","title":"Noninferiority Oral Tranexamic Acid vs Intravenous Administration in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"University of Liege","startDate":"2021-01-01","conditions":"Hemorrhage Postoperative, Total Blood Loss, Arthroplasty Complications","enrollment":230},{"nctId":"NCT04696224","phase":"NA","title":"Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA","status":"UNKNOWN","sponsor":"Universidade do Vale do Sapucai","startDate":"2020-12-18","conditions":"Hemorrhage, Fracture Femur","enrollment":90},{"nctId":"NCT05359172","phase":"","title":"The Effect of Tranexamic Acid in Total Blood Loss During Proximal Femoral Nailing","status":"COMPLETED","sponsor":"Haseki Training and Research Hospital","startDate":"2021-04-01","conditions":"Hip Fractures, Intertrochanteric Fractures, Blood Loss","enrollment":100},{"nctId":"NCT01869413","phase":"PHASE2, PHASE3","title":"Tranexamic Acid During Cystectomy Trial (TACT)","status":"COMPLETED","sponsor":"Ottawa Hospital Research Institute","startDate":"2013-06","conditions":"Bladder Cancer","enrollment":354},{"nctId":"NCT03606109","phase":"PHASE4","title":"Reducing Hemarthrosis in Tibial Tubercle Osteotomy by the Administration of Intravenous Tranexamic Acid","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2018-06-26","conditions":"Tibial Tubercle Osteotomy","enrollment":58},{"nctId":"NCT02972294","phase":"PHASE3","title":"HiFIT Study : Hip Fracture: Iron and Tranexamic Acid","status":"TERMINATED","sponsor":"University Hospital, Angers","startDate":"2017-03-31","conditions":"Hip Fractures Pathologic, Anemia","enrollment":419},{"nctId":"NCT04635007","phase":"PHASE3","title":"Tranexamic Acid Versus Misoprostol in Reducing Blood Loss in Cesarean Section in Primigravida","status":"COMPLETED","sponsor":"Cairo University","startDate":"2021-01-01","conditions":"Cesarean Section Complications, Blood Loss, Surgical, Misoprostol","enrollment":200},{"nctId":"NCT05464394","phase":"PHASE3","title":"Peroperative Administration of Tranexamic Acid in Roux-en-Y Gastric Bypass and One-anastomosis Gastric Bypass","status":"UNKNOWN","sponsor":"Franciscus Gasthuis","startDate":"2022-09-01","conditions":"Hemorrhage, Bleeding","enrollment":1524},{"nctId":"NCT03463993","phase":"PHASE3","title":"Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section","status":"COMPLETED","sponsor":"University of Zimbabwe","startDate":"2018-04-08","conditions":"Post Partum Hemorrhage","enrollment":506},{"nctId":"NCT02866838","phase":"PHASE2, PHASE3","title":"Treatment of Intracerebral Hemorrhage in Patients on Non-vitamin K Antagonist","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2016-12","conditions":"Intracerebral Hemorrhage","enrollment":64},{"nctId":"NCT04656067","phase":"PHASE1, PHASE2","title":"Comparative Study Between Oxytocin Versus Tranexamic Acid and Ethamsylate","status":"COMPLETED","sponsor":"Egymedicalpedia","startDate":"2020-04-01","conditions":"Blood Loss, Surgical, Blood Loss, Postoperative","enrollment":230},{"nctId":"NCT04803591","phase":"PHASE4","title":"This is a Study to Verify if Tranexamic Acid Can Reduce the Anemia After a Femoral Shaft Fractures Surgery","status":"WITHDRAWN","sponsor":"Christian Candrian","startDate":"2021-08-01","conditions":"Femoral Shaft Fracture","enrollment":""},{"nctId":"NCT02496364","phase":"NA","title":"Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease","status":"WITHDRAWN","sponsor":"Vinicius Magno da Rocha, MD, MSc","startDate":"2014-03-01","conditions":"Lumbar Disc Degeneration, Surgical Procedure, Unspecified","enrollment":""},{"nctId":"NCT04753151","phase":"NA","title":"The Effects of Tranexamic Acid or Placebo on Perioperative Bleeding in Adults Undergoing Liver Transplantation.","status":"UNKNOWN","sponsor":"Hospital de Clinicas de Porto Alegre","startDate":"2021-08-11","conditions":"Hemorrhage","enrollment":140},{"nctId":"NCT04494126","phase":"PHASE4","title":"Effect of Perioperative Tranexamic Acid on Blood Loss During Management of Maxillofacial Trauma","status":"UNKNOWN","sponsor":"College of Medical Sciences Teaching Hospital. Nepal","startDate":"2021-08-15","conditions":"Blood Loss","enrollment":200},{"nctId":"NCT04952285","phase":"","title":"The Efficacy and Safety of the Loading Dose of Tranexamic Acid in Scoliosis Surgery During Perioperative","status":"COMPLETED","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2015-01-01","conditions":"Tranexamic Acid","enrollment":207},{"nctId":"NCT03425799","phase":"PHASE3","title":"Efficacy and Safety of Tranexamic Acid in Spinal Fusion Surgery","status":"TERMINATED","sponsor":"Exela Pharma Sciences, LLC.","startDate":"2018-10-17","conditions":"Spinal Fusion","enrollment":5},{"nctId":"NCT04898712","phase":"PHASE2","title":"Tranexamic Acid in the Treatment of Residual Chronic Subdural Hematoma -2","status":"UNKNOWN","sponsor":"Unity Health Toronto","startDate":"2021-07","conditions":"Chronic Subdural Hematoma","enrollment":90},{"nctId":"NCT04338126","phase":"PHASE2","title":"Tranexamic Acid (TXA) and Corona Virus 2019 (COVID19) in Inpatients","status":"WITHDRAWN","sponsor":"University of Alabama at Birmingham","startDate":"2021-09-30","conditions":"COVID19","enrollment":""},{"nctId":"NCT04788121","phase":"PHASE3","title":"Efficacy of Tranexamic Acid in Upper Gastrointestinal Bleeding","status":"UNKNOWN","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2020-11-01","conditions":"Gastro Intestinal Bleeding","enrollment":160},{"nctId":"NCT03631355","phase":"PHASE4","title":"Reducing Hemarthrosis in ACL Reconstruction With BTB Autograft by the Administration of Intravenous TXA","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2018-06-06","conditions":"Anterior Cruciate Ligament Reconstruction","enrollment":110},{"nctId":"NCT03846973","phase":"PHASE3","title":"Evaluation of the Safety and Efficacy of the Second Dose of Tranexamic Acid","status":"COMPLETED","sponsor":"Hamad Medical Corporation","startDate":"2018-12-02","conditions":"Tranexamic Acid","enrollment":220},{"nctId":"NCT01728636","phase":"PHASE2","title":"The Use of Tranexamic Acid to Reduce Perioperative Blood Loss During High Risk Spine Fusion Surgery","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2013-01-15","conditions":"Curvature of Spine","enrollment":61},{"nctId":"NCT03856164","phase":"PHASE2, PHASE3","title":"Tranexamic Acid for Prevention of Hemorrhage in Cesarean Delivery","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2019-06-17","conditions":"Post Partum Hemorrhage, Fibrinolysis; Hemorrhage, Blood Loss","enrollment":110},{"nctId":"NCT04707950","phase":"PHASE1, PHASE2","title":"Tranexamic Acid for the Prevention of Postpartum Haemorrhage","status":"UNKNOWN","sponsor":"Benha University","startDate":"2020-01-01","conditions":"Postpartum Hemorrhage","enrollment":60},{"nctId":"NCT03777488","phase":"PHASE1","title":"Pharmacokinetics of Tranexamic Acid After Oral, Intramuscular or Intravenous Administration: a Prospective, Randomised, Cross-over Trial in Healthy Volunteers.","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2019-10-30","conditions":"Healthy Volunteer Study","enrollment":15},{"nctId":"NCT03697681","phase":"NA","title":"Protective Effect of Tranexamic Acid on Shedding of the Endothelial Glycocalyx in Patients Undergoing Spinal Fusion Surgery","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2018-10-16","conditions":"Posterior Lumbar Spinal Fusion Surgery","enrollment":128},{"nctId":"NCT04518163","phase":"NA","title":"Bakri Balloon Plus Tranexamic Acid During Cesarean Delivery for Placenta Previa","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2020-09-01","conditions":"Placenta Previa","enrollment":140},{"nctId":"NCT02747615","phase":"PHASE4","title":"Efficacy of Preoperative Autologous Blood Donation and Tranexamic Acid in Revision Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2010-08","conditions":"Revision Total Hip Arthroplasty (RTHA)","enrollment":60},{"nctId":"NCT04537533","phase":"PHASE4","title":"Tranexamic Acid Infusion in Low Dose Versus in High Dose for Reducing Blood Loss in Radical Cystectomy Operations","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-09","conditions":"Bleeding","enrollment":90},{"nctId":"NCT04463966","phase":"NA","title":"Prevention of Postpartum Haemorrhage","status":"UNKNOWN","sponsor":"Benha University","startDate":"2020-04-30","conditions":"Post Partum Hemorrhage","enrollment":100},{"nctId":"NCT04430777","phase":"PHASE2, PHASE3","title":"Use of Tranexamic Acid in Liposculpture","status":"COMPLETED","sponsor":"Total Definer Research Group","startDate":"2019-01-17","conditions":"Blood Loss, Surgical","enrollment":141},{"nctId":"NCT03742947","phase":"NA","title":"Haemostasis and Tranexamic Acid in Caesarean Delivery","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2019-01-10","conditions":"Postpartum Hemorrhage, Hyperfibrinolysis","enrollment":34},{"nctId":"NCT03431805","phase":"PHASE3","title":"TRAnexamic Acid for Preventing Postpartum Hemorrhage Following a Cesarean Delivery","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2018-03-03","conditions":"Postpartum Hemorrhage","enrollment":4574},{"nctId":"NCT02806024","phase":"PHASE4","title":"Perioperative Administration of Tranexamic Acid for Placenta Previa and Accreta Study","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2016-11","conditions":"Placenta Accreta, Postpartum Hemorrhage, Cesarean Section","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":185,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["intravenous saline administration"],"phase":"marketed","status":"active","brandName":"Tranexamic acid intravenous administration","genericName":"Tranexamic acid intravenous administration","companyName":"Dr. Lutfi Kirdar Kartal Training and Research Hospital","companyId":"dr-lutfi-kirdar-kartal-training-and-research-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tranexamic acid inhibits the activation of plasminogen to plasmin, thereby reducing fibrinolysis and promoting blood clot stability. Used for Reduction of blood loss in surgical procedures, Treatment of excessive bleeding in hemophilia and other bleeding disorders, Prevention and treatment of hemorrhage in trauma patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}