{"id":"tranexamic-acid-dosage-1","safety":{"commonSideEffects":[{"rate":null,"effect":"Thromboembolic events (deep vein thrombosis, pulmonary embolism)"},{"rate":null,"effect":"Gastrointestinal disturbances (nausea, vomiting, diarrhea)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Visual disturbances"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tranexamic acid is a competitive inhibitor of plasminogen and plasmin, which are key enzymes in the fibrinolytic cascade responsible for breaking down blood clots. By preventing the conversion of plasminogen to plasmin, it stabilizes fibrin clots and reduces fibrin degradation, leading to decreased bleeding. This mechanism makes it effective in controlling hemorrhage in various surgical and medical settings.","oneSentence":"Tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, thereby reducing excessive bleeding.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:41.873Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Prevention and treatment of hemorrhage in surgical procedures"},{"name":"Management of excessive bleeding in trauma and medical conditions"}]},"trialDetails":[{"nctId":"NCT03540368","phase":"NA","title":"Tranexamic Acid for The Treatment of Gastrointestinal Bleeding","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2018-07-01","conditions":"Gastrointestinal Bleeding","enrollment":48},{"nctId":"NCT04521881","phase":"PHASE3","title":"Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults","status":"RECRUITING","sponsor":"London School of Hygiene and 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