{"id":"tramadol-diclofenac-50-50","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Abdominal pain"},{"rate":"5-10%","effect":"Diarrhea"},{"rate":"5-10%","effect":"Constipation"},{"rate":"2-5%","effect":"Vomiting"},{"rate":"2-5%","effect":"Somnolence"},{"rate":"2-5%","effect":"Fatigue"},{"rate":"2-5%","effect":"Insomnia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Tramadol works by binding to opioid receptors in the brain and spinal cord, reducing the perception of pain. Diclofenac, on the other hand, blocks the production of prostaglandins, which are chemicals that cause inflammation and pain. The combination of both drugs provides analgesic and anti-inflammatory effects.","oneSentence":"Tramadol is a centrally acting opioid analgesic, while diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:39:42.251Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe pain"},{"name":"Inflammatory pain"}]},"trialDetails":[{"nctId":"NCT06231043","phase":"PHASE4","title":"Diclofenac IM Versus Tramadol IV in Acute Renal Colic, RCT","status":"COMPLETED","sponsor":"Lampang Hospital","startDate":"2022-04-27","conditions":"Acute Renal Colic","enrollment":68},{"nctId":"NCT05507554","phase":"NA","title":"Different Postoperative Analgesics Use After Ureteroscopy","status":"UNKNOWN","sponsor":"Pakistan Kidney and Liver Institute and Research Center","startDate":"2022-08-01","conditions":"Post Operative Pain, Ureteroscopy, Ureter Stone","enrollment":176},{"nctId":"NCT05488925","phase":"PHASE4","title":"Comparison of Preoperative Analgesics on the Efficacy of Inferior Alveolar Nerve Block.","status":"COMPLETED","sponsor":"Farjad Zafar","startDate":"2021-06-21","conditions":"Symptomatic Irreversible Pulpitis","enrollment":120},{"nctId":"NCT03380533","phase":"PHASE2, PHASE3","title":"Buprenorphine Transdermal Patches in Arthroscopic Rotator Cuff Repair","status":"COMPLETED","sponsor":"Hospital Italiano de Buenos Aires","startDate":"2016-09-22","conditions":"Rotator Cuff Tear, Rotator Cuff Injury, Analgesics, Opioid","enrollment":50},{"nctId":"NCT03714672","phase":"PHASE3","title":"Tramadol/Diclofenac Fixed-dose Combination Phase III Trial in Acute Pain After Third Molar Extraction","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2017-08-26","conditions":"Acute Pain","enrollment":1151},{"nctId":"NCT03829774","phase":"NA","title":"To Study and Evaluate the Effectiveness of Treatment by Percutaneous Electrical NeuroStimulation (PENS) for Post-operative Pain in Cesarean Section Patients Using Primary Relief v 2.0","status":"UNKNOWN","sponsor":"DyAnsys, Inc.","startDate":"2019-01-02","conditions":"Cesarean Section; Dehiscence","enrollment":22},{"nctId":"NCT02445599","phase":"PHASE4","title":"Diclofenac Premedication, as the Effect of Preemptive Analgesia After Post-thoracotomy Chest and Shoulder Pain","status":"COMPLETED","sponsor":"University of Debrecen","startDate":"2014-04","conditions":"Pain, Inadequate or Impaired Respiratory Function","enrollment":3},{"nctId":"NCT02425709","phase":"PHASE3","title":"Tramadol Versus Diclofenac for Reducing Pain Before Outpatient Hysteroscopy in Post Menopausal Women","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2015-04","conditions":"Hysteroscopy, Pain","enrollment":210},{"nctId":"NCT02658721","phase":"PHASE3","title":"Effects of Systemic or Adjunct Tramadol Addition to Lidocaine Used for IVRA in Patients Undergoing Hand Surgery","status":"COMPLETED","sponsor":"Bagcilar Training and Research Hospital","startDate":"2013-01","conditions":"Anesthesia","enrollment":60},{"nctId":"NCT00766402","phase":"PHASE4","title":"An Efficacy and Safety Study of Tramadol/Acetaminophen Versus Diclofenac in the Treatment of Pain in Participants With Ankylosing Spondylitis Receiving Stable Treatment of Disease Modifying Anti-rheumatic Drugs (DMARDs)","status":"TERMINATED","sponsor":"Johnson & Johnson Taiwan Ltd","startDate":"2008-10","conditions":"Spondylitis, Ankylosing, Pain","enrollment":8}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Adorlan Forte (Registered Trademark)"],"phase":"phase_3","status":"active","brandName":"Tramadol/Diclofenac 50/50","genericName":"Tramadol/Diclofenac 50/50","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tramadol is a centrally acting opioid analgesic, while diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis. Used for Moderate to severe pain, Inflammatory pain.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}