{"id":"training-simvastatin-q10","safety":{"commonSideEffects":[{"rate":null,"effect":"Muscle pain or myalgia (simvastatin)"},{"rate":null,"effect":"Elevated liver enzymes (simvastatin)"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":{"chemblId":"CHEMBL1201391","moleculeType":"Small molecule","molecularWeight":"436.59"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Simvastatin inhibits HMG-CoA reductase to lower LDL cholesterol and reduce atherosclerotic cardiovascular disease risk. CoQ10 supplementation counteracts statin-induced depletion of this essential mitochondrial cofactor, potentially improving muscle function and energy metabolism. Exercise training enhances cardiovascular fitness and metabolic health synergistically with pharmacotherapy.","oneSentence":"This combination therapy uses exercise training with simvastatin (a statin) and coenzyme Q10 (CoQ10) to reduce cardiovascular risk through lipid lowering and mitochondrial support.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:13:25.958Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cardiovascular risk reduction in patients with dyslipidemia or statin-treated populations"}]},"trialDetails":[{"nctId":"NCT02796378","phase":"PHASE4","title":"Living With Statins - Interventional Exercise Study","status":"UNKNOWN","sponsor":"University of Copenhagen","startDate":"2016-06","conditions":"Cardiovascular Disease, Diabetes Mellitus","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Simvastatin KRKA","SQ"],"phase":"marketed","status":"active","brandName":"Training+Simvastatin+Q10","genericName":"Training+Simvastatin+Q10","companyName":"University of Copenhagen","companyId":"university-of-copenhagen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"The \"Living With Statins - Interventional Exercise Study\" (LIFESTAT) investigated the effects of training combined with simvastatin and coenzyme Q10 on cardiovascular disease and diabetes mellitus. Simvastatin is a small molecule that lowers cholesterol levels, and its mechanism of action is not specified in the provided information.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}