{"id":"traditional-vitamin-d-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypercalcemia"},{"rate":null,"effect":"Hypercalciuria"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Constipation"}]},"_chembl":{"chemblId":"CHEMBL1536","moleculeType":"Small molecule","molecularWeight":"396.66"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vitamin D is converted in the liver to 25-hydroxyvitamin D (the major circulating form) and then in the kidneys to 1,25-dihydroxyvitamin D (the active hormonal form), which binds to the vitamin D receptor to regulate calcium and phosphate absorption in the intestines and bone metabolism. This supports skeletal health and modulates immune and cardiovascular function.","oneSentence":"Vitamin D supplementation increases serum 25-hydroxyvitamin D levels to support calcium homeostasis, bone mineralization, and immune function.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:24.420Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Vitamin D deficiency"},{"name":"Osteoporosis prevention and treatment"},{"name":"Hypoparathyroidism"}]},"trialDetails":[{"nctId":"NCT07349459","phase":"NA","title":"Cardioprotective Effect of Melatonin Versus Vitamin D in Breast Cancer Patients Receiving Doxorubicin","status":"NOT_YET_RECRUITING","sponsor":"Tanta University","startDate":"2026-04-30","conditions":"Melatonin, Breast Cancer Patients Diagnosed, Vitamin D Concentration","enrollment":90},{"nctId":"NCT05392790","phase":"NA","title":"Progressive Resisted Exercise Plus Aerobic Exercise on Osteoporotic Systemic Lupus Erythmatosus","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-05-23","conditions":"Systemic Lupus Erythematosus","enrollment":80},{"nctId":"NCT03984890","phase":"PHASE2, PHASE3","title":"Vitamin D3 For CGD Patients With BCGosis/Itis","status":"COMPLETED","sponsor":"Children's Hospital of Fudan University","startDate":"2019-08-01","conditions":"Vitamin D3, Chronic-granulomatous Disease, BCG","enrollment":50},{"nctId":"NCT05977166","phase":"NA","title":"Hyperbaric on Pulmonary Functions in Post Covid -19 Patients.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-03-07","conditions":"Post COVID-19 Patients","enrollment":72},{"nctId":"NCT04841213","phase":"NA","title":"Dental Implants Rehabilitation in Patients With Vitamin D3 Imbalance","status":"COMPLETED","sponsor":"I.M. Sechenov First Moscow State Medical University","startDate":"2021-04-10","conditions":"Tooth Loss, Vitamin D3 Deficiency, Osteomalacia","enrollment":384},{"nctId":"NCT05045937","phase":"","title":"Observational Study on the Use of Ivermectin as an Outpatient Treatment Option for COVID-19","status":"UNKNOWN","sponsor":"Patrick Robinson","startDate":"2022-05-01","conditions":"Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection","enrollment":1000},{"nctId":"NCT04958980","phase":"NA","title":"Multiprofessional Approach in Diabetes Mellitus","status":"UNKNOWN","sponsor":"Leonardo Paroche de Matos","startDate":"2021-08","conditions":"Diabetes Mellitus, Type 2","enrollment":24},{"nctId":"NCT04301336","phase":"PHASE2, PHASE3","title":"Different Treatment Modalities in the Management of the Painful Crisis in Pediatric Sickle- Cell Anemia","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2019-11-01","conditions":"Vaso-occlusive Crisis, Sickle Cell Disease, Sickle Cell Anemia in Children","enrollment":350},{"nctId":"NCT04637360","phase":"NA","title":"Bone Markers and Bone Density Changes in Hyperperparathyroid Dialysis Patients Under Cinacalcet Treatment","status":"COMPLETED","sponsor":"Min-Sheng General Hospital","startDate":"2018-01-01","conditions":"Hyperparathyroidism; Secondary, Renal","enrollment":40},{"nctId":"NCT01181531","phase":"PHASE4","title":"Compare the Efficacy of Cinacalcet vs Traditional Vitamin D for Secondary Hyperparathyroidism (SHPT) Among Subjects Undergoing Hemodialysis","status":"COMPLETED","sponsor":"Amgen","startDate":"2010-10-01","conditions":"Hyperparathyroidism, Secondary","enrollment":312}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Traditional Vitamin D Therapy","genericName":"Traditional Vitamin D Therapy","companyName":"Amgen","companyId":"amgen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vitamin D supplementation increases serum 25-hydroxyvitamin D levels to support calcium homeostasis, bone mineralization, and immune function. Used for Vitamin D deficiency, Osteoporosis prevention and treatment, Hypoparathyroidism.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}