{"id":"traditional-anticoagulation","safety":{"commonSideEffects":[{"rate":"1-5","effect":"Bleeding (major and minor)"},{"rate":"5-15","effect":"Bruising"},{"rate":"1-3","effect":"Gastrointestinal bleeding"},{"rate":"0.5-1","effect":"Intracranial hemorrhage"},{"rate":"0.1-0.5","effect":"Warfarin necrosis (with warfarin)"}]},"_chembl":{"chemblId":"CHEMBL2108251","moleculeType":"Oligosaccharide"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Traditional anticoagulants work by interfering with the body's natural blood clotting cascade. Warfarin (a vitamin K antagonist) inhibits factors II, VII, IX, and X, while older parenteral agents like heparin inhibit thrombin and factor Xa directly. These mechanisms reduce the ability of blood to form pathological clots while maintaining hemostasis.","oneSentence":"Traditional anticoagulation prevents blood clot formation by inhibiting coagulation cascade factors, typically through vitamin K antagonism or direct thrombin/factor Xa inhibition.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:38:54.117Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atrial fibrillation for stroke prevention"},{"name":"Venous thromboembolism (DVT/PE) treatment and prophylaxis"},{"name":"Mechanical heart valve thromboprophylaxis"},{"name":"Acute coronary syndrome"}]},"trialDetails":[{"nctId":"NCT04956978","phase":"NA","title":"Shared Decision Making to Address Racial Disparities in Oral Anticoagulation in NVAF","status":"NOT_YET_RECRUITING","sponsor":"Duke University","startDate":"2026-06-01","conditions":"Atrial Fibrillation","enrollment":40},{"nctId":"NCT06085495","phase":"NA","title":"Mechanical Thrombectomy for Acute Lower Limb Deep Vein Thrombosis in Tumor Patients","status":"COMPLETED","sponsor":"RenJi Hospital","startDate":"2023-01-23","conditions":"Cancer Patients With Acute Lower Limb Deep Vein Thrombosis (DVT)","enrollment":52},{"nctId":"NCT04936191","phase":"NA","title":"Dynamic Change of Coronary Artery Curvature","status":"COMPLETED","sponsor":"National Taiwan University Hospital","startDate":"2022-11-18","conditions":"Coronary Artery Disease","enrollment":48},{"nctId":"NCT06715930","phase":"","title":"Nomogram for Predicting In-stent Stenosis After Pipeline Embolization Device Treatment in Patients with Intracranial Aneurysm","status":"ACTIVE_NOT_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2016-04-01","conditions":"Intracranial Aneurysm","enrollment":1500},{"nctId":"NCT06476301","phase":"PHASE4","title":"Efficacy and Safety of Rivaroxaban in the Early Postoperative Period for Patients With Bioprosthetic Valves","status":"NOT_YET_RECRUITING","sponsor":"RenJi Hospital","startDate":"2024-08-01","conditions":"Anticoagulation","enrollment":250},{"nctId":"NCT05977166","phase":"NA","title":"Hyperbaric on Pulmonary Functions in Post Covid -19 Patients.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2022-03-07","conditions":"Post COVID-19 Patients","enrollment":72},{"nctId":"NCT05147077","phase":"NA","title":"Integrated Rehabilitation in Treating Post-stroke Anxiety","status":"UNKNOWN","sponsor":"The Third Affiliated hospital of Zhejiang Chinese Medical University","startDate":"2022-01-24","conditions":"Post-stroke, Anxiety","enrollment":188},{"nctId":"NCT05187975","phase":"NA","title":"Integrated Rehabilitation in Treating Post-stroke Depression","status":"UNKNOWN","sponsor":"The Third Affiliated hospital of Zhejiang Chinese Medical University","startDate":"2022-01-24","conditions":"Post-stroke Depression","enrollment":202},{"nctId":"NCT04994223","phase":"EARLY_PHASE1","title":"Effectiveness of Combined Anticoagulation and Antithrombotic Therapy vs Antithrombotic Therapy Alone After Lower Extremity Revascularization for Peripheral Arterial Disease","status":"UNKNOWN","sponsor":"Armed Forces Post Graduate Medical Institute (AFPGMI), Rawalpindi","startDate":"2021-07-02","conditions":"Combined Anticoagulation and Antithrombotic Therapy, PAD - Peripheral Arterial Disease","enrollment":60},{"nctId":"NCT04301921","phase":"NA","title":"Strategies to Maintain Radial Artery Patency Following Diagnostic Coronary Angiography - Diagnostic Transradial Coronary Angiography Without Systemic Anticoagulatio","status":"UNKNOWN","sponsor":"Prof. Dr. med. Ingo Eitel","startDate":"2020-05-01","conditions":"Patients Undergoing Diagnostic Coronary Angiography","enrollment":400},{"nctId":"NCT02592980","phase":"PHASE4","title":"Evaluation of a Pharmacogenetic-based Warfarin Dosing Algorithm in Patients","status":"UNKNOWN","sponsor":"University of Sao Paulo General Hospital","startDate":"2016-01","conditions":"Atrial Fibrillation","enrollment":300},{"nctId":"NCT02987192","phase":"NA","title":"Minimally Invasive Lumbar Aneasthesia Used for Cesarean Section","status":"UNKNOWN","sponsor":"RenJi Hospital","startDate":"2016-11","conditions":"Anticoagulation, Minimally Invasive, Spinal Anesthesia","enrollment":200},{"nctId":"NCT02723981","phase":"PHASE4","title":"COMBO-Stent in Patients on Chronic Anticoagulant Therapy (COSTA) COSTA-Bleed and COSTA-Outcome Trials","status":"WITHDRAWN","sponsor":"IHF GmbH - Institut für Herzinfarktforschung","startDate":"2016-04","conditions":"Stable Angina, Unstable Angina, STEMI","enrollment":""},{"nctId":"NCT02849522","phase":"","title":"ROPE Registry Project to Determine the Safety and Efficacy of Prostate Artery Embolisation (PAE) for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Enlargement (LUTS BPE).","status":"UNKNOWN","sponsor":"Cedar, United Kingdom","startDate":"2014-04","conditions":"Lower Urinary Tract Symptoms Caused by Benign Prostatic Enlargement (LUTS BPE), Prostate Artery Embolisation (PAE), Transurethral Resection of the Prostate (TURP)","enrollment":300},{"nctId":"NCT00700895","phase":"PHASE3","title":"Assessing the Clinical Benefits of a Pharmacogenetics-Guided Dosing Regiment for Calculating Warfarin Maintenance Dose","status":"UNKNOWN","sponsor":"National University Hospital, Singapore","startDate":"2006-08","conditions":"Indications for Warfarin Therapy","enrollment":320},{"nctId":"NCT01298986","phase":"EARLY_PHASE1","title":"Atrial Fibrillation Ablation The Hybrid Approach Versus Traditional Management","status":"WITHDRAWN","sponsor":"Inova Health Care Services","startDate":"2011-05","conditions":"Ablation of Atrial Fibrillation","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":67,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Warfarin"],"phase":"marketed","status":"active","brandName":"Traditional anticoagulation","genericName":"Traditional anticoagulation","companyName":"University of Sao Paulo General Hospital","companyId":"university-of-sao-paulo-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Traditional anticoagulation involves the use of medications such as rivaroxaban, which is an oligosaccharide modality, to prevent blood clot formation. It is studied in various conditions including peripheral arterial disease, stable and unstable angina, and is also used in combination with antithrombotic therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}