{"id":"trabeculectomy-with-mmc","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotony (low intraocular pressure)"},{"rate":null,"effect":"Bleb-related infection (blebitis/endophthalmitis)"},{"rate":null,"effect":"Cataract progression"},{"rate":null,"effect":"Corneal erosion or scarring"},{"rate":null,"effect":"Hyphema"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Trabeculectomy is a glaucoma surgery that removes a portion of the trabecular meshwork to allow aqueous humor to drain from the anterior chamber into a subconjunctival bleb, thereby lowering intraocular pressure. Mitomycin C (MMC) is an antimetabolite applied intraoperatively to inhibit fibroblast proliferation and reduce postoperative scarring, which improves the long-term success rate of the filtration bleb.","oneSentence":"Trabeculectomy with MMC is a surgical procedure that creates a drainage pathway in the eye while using mitomycin C to prevent scar tissue formation and maintain long-term filtration.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:32.047Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Open-angle glaucoma refractory to medical therapy"},{"name":"Angle-closure glaucoma"},{"name":"Secondary glaucomas"}]},"trialDetails":[{"nctId":"NCT07496957","phase":"NA","title":"Preserflo MicroShunt Versus Trabeculectomy","status":"RECRUITING","sponsor":"Medical University of Bialystok","startDate":"2026-03-01","conditions":"GLAUCOMA 1, OPEN ANGLE, D (Disorder)","enrollment":100},{"nctId":"NCT07303257","phase":"","title":"Quality of Life After Glaucoma Surgery: Evaluating the Patient Perspective Across Surgical Options","status":"RECRUITING","sponsor":"Hospices Civils de Lyon","startDate":"2026-02-23","conditions":"Glaucoma Eye, Open-angle Glaucoma, Closed-Angle Glaucoma","enrollment":132},{"nctId":"NCT07358650","phase":"NA","title":"Clinical Study Evaluating the Safety and Performance of the MIST Device for Intraocular Pressure Reduction in Patients With Primary Open-Angle Glaucoma","status":"RECRUITING","sponsor":"Hexiris Inc","startDate":"2026-01-15","conditions":"Primary Open Angle Glaucoma","enrollment":25},{"nctId":"NCT07152132","phase":"NA","title":"SCTSC Versus Trabeculectomy in Medically Uncontrolled Open-Angle Glaucoma in Pseudophakic Patients","status":"RECRUITING","sponsor":"Minia University","startDate":"2025-07-20","conditions":"Glaucoma, Open Angle","enrollment":50},{"nctId":"NCT03648814","phase":"NA","title":"Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT","status":"RECRUITING","sponsor":"Prince of Songkla University","startDate":"2018-08-01","conditions":"Glaucoma, Neovascular, Vascular Endothelial Growth Factor Overexpression","enrollment":40},{"nctId":"NCT07034651","phase":"NA","title":"Electron Microscopic Examination of Iris Tissue in Buphthalmos","status":"COMPLETED","sponsor":"Assiut University","startDate":"2024-06-01","conditions":"Iris Diseases","enrollment":20},{"nctId":"NCT03931564","phase":"NA","title":"SIGHT Study: Cost-effectiveness of InnFocus Microshunt Implantation vs. Trabeculectomy.","status":"UNKNOWN","sponsor":"Maastricht University Medical Center","startDate":"2020-02-01","conditions":"Primary Open-angle Glaucoma","enrollment":124},{"nctId":"NCT04727411","phase":"NA","title":"Analysis of Conjunctival Changes as Indicators for Ab-interno Gelatin Microstent Implantation Surgery Outcomes","status":"COMPLETED","sponsor":"Hospital Clinic of Barcelona","startDate":"2021-01-01","conditions":"Glaucoma, Glaucoma Open-Angle Primary","enrollment":39},{"nctId":"NCT03548805","phase":"NA","title":"Ologen® Collagen Matrix Versus Mitomycin-C in Patients With Juvenile-onset Open Angle Glaucoma","status":"COMPLETED","sponsor":"L.V. Prasad Eye Institute","startDate":"2018-08-16","conditions":"Open Angle Glaucoma","enrollment":30},{"nctId":"NCT03766425","phase":"EARLY_PHASE1","title":"Comparison of Efficacy and Safety of Mitomycin and Aflibercept Used to Support Primary Trabeculectomy.","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2017-06-14","conditions":"Eye Diseases, Optic Nerve Damage, Glaucoma Surgery","enrollment":64},{"nctId":"NCT06000280","phase":"NA","title":"Evaluation of Retina in Patients With Glaucoma Using Topical Prostaglandins Undergoing Trabeculectomy Surgery","status":"COMPLETED","sponsor":"Universidade Federal de Goias","startDate":"2021-01-04","conditions":"Glaucoma","enrollment":37},{"nctId":"NCT04647929","phase":"NA","title":"Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas","status":"WITHDRAWN","sponsor":"University of Zurich","startDate":"2020-12-01","conditions":"Primary Congenital Glaucoma, Developmental Glaucoma","enrollment":""},{"nctId":"NCT01881425","phase":"NA","title":"InnFocus MicroShunt Versus Trabeculectomy Study","status":"COMPLETED","sponsor":"InnFocus Inc.","startDate":"2015-12-15","conditions":"Primary Open Angle Glaucoma","enrollment":732},{"nctId":"NCT00666237","phase":"PHASE4","title":"Primary Tube Versus Trabeculectomy Study","status":"COMPLETED","sponsor":"University of Miami","startDate":"2008-04-01","conditions":"Glaucoma","enrollment":242},{"nctId":"NCT04750447","phase":"","title":"Safety and Efficacy of an Ab Interno Gelatin Stent (XEN63) With or Without Mitomycin C","status":"UNKNOWN","sponsor":"Prism Eye Institute","startDate":"2020-11-09","conditions":"Glaucoma, Open-Angle","enrollment":30},{"nctId":"NCT03480711","phase":"NA","title":"Modified Trabeculectomy With an ESST Versus Conventional SST for Management of Primary Open Angle Glaucoma","status":"COMPLETED","sponsor":"Rehab mahmoud abdelhamid mohamed","startDate":"2018-07-10","conditions":"Primary Open-angle Glaucoma","enrollment":40},{"nctId":"NCT05205122","phase":"NA","title":"Evaluation of Primary Congenital Glaucoma at Asyut University Hospital","status":"UNKNOWN","sponsor":"Omar Abdelkarem Hasan","startDate":"2022-02-01","conditions":"Primary Congenital Glaucoma","enrollment":30},{"nctId":"NCT05126069","phase":"","title":"Ab Interno Gelatin Microstent With MMC vs. Trabeculectomy With MMC: 3 Year Retrospective Cohort Analysis","status":"COMPLETED","sponsor":"Prism Eye Institute","startDate":"2018-08-21","conditions":"Filtering Surgery, Trabeculectomy","enrollment":242},{"nctId":"NCT04683055","phase":"NA","title":"Phaco-Trabeculotomy Vs Phaco-Trabeculectomy","status":"COMPLETED","sponsor":"Assiut University","startDate":"2020-10-28","conditions":"Ophthalmopathy, Glaucoma, Glaucoma, Angle-Closure","enrollment":50},{"nctId":"NCT04970251","phase":"NA","title":"Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma","status":"COMPLETED","sponsor":"Siriraj Hospital","startDate":"2018-11-01","conditions":"Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression","enrollment":5},{"nctId":"NCT01922154","phase":"PHASE4","title":"Intravitreous Ranibizumab as Adjunctive Treatment for Trabeculectomy in Neovascular Glaucoma","status":"COMPLETED","sponsor":"Siriraj Hospital","startDate":"2009-02","conditions":"Glaucoma, Neovascular","enrollment":15},{"nctId":"NCT02955849","phase":"EARLY_PHASE1","title":"A Trial of China Laser and Surgery Study Glaucoma in Rural China","status":"COMPLETED","sponsor":"Sun Yat-sen University","startDate":"2016-09","conditions":"Glaucoma","enrollment":200},{"nctId":"NCT04709497","phase":"NA","title":"Surgery for Primary Congenital Glaucoma in Neonates","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2021-03-01","conditions":"Primary Congenital Glaucoma","enrollment":60},{"nctId":"NCT04673201","phase":"NA","title":"Management Steroid Induced Glaucoma","status":"UNKNOWN","sponsor":"Mansoura University","startDate":"2020-11-21","conditions":"Steroid-Induced Glaucoma","enrollment":86},{"nctId":"NCT04079725","phase":"NA","title":"Iris Tissue in Primary Congenital Glaucoma","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-12","conditions":"Primary Congenital Glaucoma","enrollment":15},{"nctId":"NCT00444080","phase":"NA","title":"Comparison of Ex-PRESSTM Mini Glaucoma Shunt to Trabeculectomy in Subjects With Open Angle Glaucoma","status":"COMPLETED","sponsor":"University of Virginia","startDate":"2006-10","conditions":"Glaucoma","enrollment":120},{"nctId":"NCT04493073","phase":"EARLY_PHASE1","title":"Conjunctival Vascularity Changes Usnig OCTA After Trabeculectomy","status":"UNKNOWN","sponsor":"Asmaa Ahmed Ali Youssif","startDate":"2020-12-01","conditions":"OCTA","enrollment":100},{"nctId":"NCT04352660","phase":"PHASE4","title":"Subconjunctival Versus Direct Mitomycin C in Trabeculectomy","status":"COMPLETED","sponsor":"University of California, San Diego","startDate":"2016-05-23","conditions":"Open Angle Glaucoma","enrollment":100},{"nctId":"NCT04417920","phase":"NA","title":"Express Implant Versus Trabeculectomy After Late Failure Trabeculectomy","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2017-07-01","conditions":"Glaucoma","enrollment":28},{"nctId":"NCT04011878","phase":"NA","title":"Histopathological Examination of Iris Tissue in Buphthalmos","status":"COMPLETED","sponsor":"Assiut University","startDate":"2016-01","conditions":"Iris Disease","enrollment":11},{"nctId":"NCT03924544","phase":"PHASE1","title":"Decorin in Sub Scleral Trabeculectomy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2019-09-01","conditions":"Primary Open-angle Glaucoma","enrollment":52},{"nctId":"NCT01115218","phase":"","title":"The Influence of Anterior Chamber Fluid Mediators on the Success Rate of Trabeculectomy","status":"COMPLETED","sponsor":"University of Cologne","startDate":"2009-10","conditions":"Glaucoma, Trabeculectomy, Wound Healing","enrollment":62},{"nctId":"NCT00853073","phase":"PHASE2, PHASE3","title":"Does Adding Bevacizumab Therapy in Glaucoma Surgery Improve the Success of Needle Bleb Revisions?","status":"COMPLETED","sponsor":"Wills Eye","startDate":"2009-02","conditions":"Glaucoma","enrollment":63},{"nctId":"NCT03506542","phase":"PHASE2","title":"Phacotrabeculectomy With Collagen Matrix Implant (Ologen®) Versus Mitomycin C","status":"COMPLETED","sponsor":"Medical University of Lublin","startDate":"2014-06-02","conditions":"Glaucoma, Cataract, Wound Heal","enrollment":53},{"nctId":"NCT00626782","phase":"PHASE2, PHASE3","title":"Lucentis Versus Mitomycin C During Glaucoma Surgery","status":"COMPLETED","sponsor":"Wills Eye","startDate":"2008-01","conditions":"Glaucoma","enrollment":24},{"nctId":"NCT02406833","phase":"PHASE1","title":"Phase I Dose Escalation Study to Investigate the Safety of ISTH0036 in Subjects With Glaucoma Undergoing Trabeculectomy","status":"COMPLETED","sponsor":"Isarna Therapeutics GmbH","startDate":"2015-04","conditions":"Primary Open Angle Glaucoma","enrollment":13},{"nctId":"NCT02016898","phase":"PHASE2","title":"The Effect of Sponge Versus No-Sponge Placement of Mitomycin-C on the Outcomes of Trabeculectomy With Ex-PRESS Glaucoma Filtration Device","status":"COMPLETED","sponsor":"Duke University","startDate":"2014-03","conditions":"Primary Open Angle Glaucoma","enrollment":100},{"nctId":"NCT03395535","phase":"PHASE4","title":"Laser-1st vs Drops-1st for Glaucoma and Ocular Hypertension","status":"COMPLETED","sponsor":"Moorfields Eye Hospital NHS Foundation Trust","startDate":"2012-10-01","conditions":"Primary Open Angle Glaucoma, Ocular Hypertension","enrollment":718},{"nctId":"NCT01440751","phase":"PHASE4","title":"Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Glaucoma Filtering Surgery","status":"COMPLETED","sponsor":"Aeon Astron Europe B.V.","startDate":"2011-09","conditions":"Glaucoma","enrollment":99},{"nctId":"NCT03293251","phase":"","title":"Trabeculectomy With MMC and I Stent in Uveitic Glaucoma and POAG : Outcomes and Prognostic Factors","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2017-08-01","conditions":"Outcomes of Trabeculectomy With MMC","enrollment":70},{"nctId":"NCT03274024","phase":"NA","title":"The Asia Primary Tube Versus Trab (TVT) Study","status":"UNKNOWN","sponsor":"Singapore Eye Research Institute","startDate":"2016-09-28","conditions":"Glaucoma","enrollment":300},{"nctId":"NCT02989207","phase":"NA","title":"Surgical Approaches in Treating Uncontrolled Glaucoma in Black African and African-Caribbeans","status":"UNKNOWN","sponsor":"Guy's and St Thomas' NHS Foundation Trust","startDate":"2016-08","conditions":"Primary Open Angle Glaucoma","enrollment":60},{"nctId":"NCT00661583","phase":"PHASE1, PHASE2","title":"Use of Ranibizumab With Mitomycin C During Trabeculectomy","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2008-04","conditions":"Glaucoma","enrollment":30},{"nctId":"NCT02901236","phase":"PHASE2, PHASE3","title":"Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma","status":"COMPLETED","sponsor":"Athens Vision Eye Institute","startDate":"2014-01","conditions":"Glaucoma","enrollment":40},{"nctId":"NCT00901108","phase":"PHASE3","title":"Trabectome Versus Trabeculectomy With Mitomycin C in Patients With Open Angle Glaucoma","status":"TERMINATED","sponsor":"University of Alberta","startDate":"2009-11","conditions":"Open Angle Glaucoma","enrollment":19},{"nctId":"NCT00306852","phase":"NA","title":"Tube Versus Trabeculectomy (TVT) Study","status":"COMPLETED","sponsor":"University of Miami","startDate":"1999-10","conditions":"Glaucoma","enrollment":212},{"nctId":"NCT02287545","phase":"","title":"Biomechanical Changes After Trabeculectomy","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2013-02","conditions":"Glaucoma, Primary","enrollment":30},{"nctId":"NCT00863018","phase":"","title":"Corneal Endothelium After Glaucoma Surgery","status":"COMPLETED","sponsor":"Chungnam National University","startDate":"2003-08","conditions":"Glaucoma, Corneal Damage, Intraocular Pressure","enrollment":61},{"nctId":"NCT02385370","phase":"PHASE3","title":"Bleb Function and Morphology With Intratendon Injection of MMC Compared With Standard Method","status":"UNKNOWN","sponsor":"Shahid Beheshti University of Medical Sciences","startDate":"2014-12","conditions":"Glaucoma","enrollment":126},{"nctId":"NCT00892398","phase":"NA","title":"Trabeculectomy With Mitomycin C Associated With Sub-conjunctival Injection of Ranibizumab","status":"COMPLETED","sponsor":"Maisonneuve-Rosemont Hospital","startDate":"2009-03","conditions":"Glaucoma","enrollment":242},{"nctId":"NCT02088528","phase":"NA","title":"The Ghana Primary Tube Versus Trabeculectomy Study","status":"UNKNOWN","sponsor":"Tema Christian Eye Center","startDate":"2014-03","conditions":"Glaucoma","enrollment":298},{"nctId":"NCT01263834","phase":"PHASE2, PHASE3","title":"Results of Adjunctive Intraoperative Bevacizumab Injection on Trabeculectomy Outcome","status":"COMPLETED","sponsor":"Prince of Songkla University","startDate":"2010-12","conditions":"Glaucoma","enrollment":39},{"nctId":"NCT01391676","phase":"","title":"Imaging of Trabeculectomy Blebs Using the Spectral Domain Optical Coherence Tomography","status":"COMPLETED","sponsor":"Technische Universität Dresden","startDate":"2011-03","conditions":"Glaucoma, Filtering Blebs","enrollment":30},{"nctId":"NCT01228799","phase":"NA","title":"Trabeculectomy Versus Canaloplasty","status":"COMPLETED","sponsor":"University Eye Hospital, Würzburg","startDate":"2010-06","conditions":"Glaucoma, Canaloplasty, Trabeculectomy","enrollment":64},{"nctId":"NCT00854256","phase":"NA","title":"Trabeculectomy Versus Canaloplasty to Treat Glaucoma","status":"UNKNOWN","sponsor":"University of Cologne","startDate":"2009-04","conditions":"Glaucoma","enrollment":60},{"nctId":"NCT01633775","phase":"","title":"Re-Trabeculectomy Versus Ahmed Glaucoma Valve Implantation in Secondary Surgical Management of Patients With Refractory Glaucoma","status":"COMPLETED","sponsor":"Vanak Eye Surgery Center","startDate":"2007-12","conditions":"Refractory Primary Open Angle Glaucoma","enrollment":100},{"nctId":"NCT00538590","phase":"PHASE4","title":"Ologen Collagen Matrix Safety and Effective Comparison With Mitomycin-C(MMC) in Glaucoma Surgery","status":"COMPLETED","sponsor":"Pro Top & Mediking Company Limited","startDate":"2007-07","conditions":"Open Angle Glaucoma","enrollment":20},{"nctId":"NCT00472810","phase":"PHASE3","title":"Ologen (OculusGen)-Glaucoma MMC Control in Pakistan","status":"COMPLETED","sponsor":"Pro Top & Mediking Company Limited","startDate":"2007-03","conditions":"Glaucoma, Trabeculectomy","enrollment":40},{"nctId":"NCT00449098","phase":"PHASE4","title":"Ologen (OculusGen)-Glaucoma MMC Control Trial in India","status":"UNKNOWN","sponsor":"Pro Top & Mediking Company Limited","startDate":"2007-01","conditions":"Glaucoma","enrollment":40},{"nctId":"NCT01174420","phase":"NA","title":"Comparative Study of Ologen Collagen Matrix Versus Mitomycin-C in Trabeculectomy: A Study in Germany","status":"UNKNOWN","sponsor":"Aeon Astron Europe B.V.","startDate":"2009-11","conditions":"Open-angle Glaucoma","enrollment":40},{"nctId":"NCT01310764","phase":"NA","title":"Trabeculectomy With Subconjunctival Bevacizumab Injection","status":"COMPLETED","sponsor":"Rassoul Akram Hospital","startDate":"2009-04","conditions":"Glaucoma","enrollment":36},{"nctId":"NCT00597181","phase":"PHASE4","title":"A Clinical Study Comparing the Inflammatory Response of the Ex-Press Mini Shunt to Trabeculectomy","status":"TERMINATED","sponsor":"Indiana University","startDate":"2007-11","conditions":"Glaucoma","enrollment":40},{"nctId":"NCT00854529","phase":"PHASE2","title":"Subconjunctival Bevacizumab Effect on Bleb Vascularity","status":"UNKNOWN","sponsor":"Rabin Medical Center","startDate":"2009-04","conditions":"Bleb Vascularity, Bleb Fibrosis, Trabeculectomy Failure","enrollment":60},{"nctId":"NCT00687791","phase":"PHASE3","title":"Oculusgen (Ologen) Collagen Matrix Implant for Phaco-Trabeculectomy in Primary Glaucoma: A Case-Control Study","status":"UNKNOWN","sponsor":"Pro Top & Mediking Company Limited","startDate":"2007-12","conditions":"Cataract, Glaucoma","enrollment":20},{"nctId":"NCT00698438","phase":"PHASE4","title":"Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study","status":"COMPLETED","sponsor":"University of Witwatersrand, South Africa","startDate":"2005-03","conditions":"Glaucoma","enrollment":30},{"nctId":"NCT00665756","phase":"NA","title":"Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves and Second Trabeculectomy in Glaucoma Patients","status":"UNKNOWN","sponsor":"Federal University of São Paulo","startDate":"2006-01","conditions":"Open Angle Glaucoma","enrollment":40},{"nctId":"NCT00449631","phase":"","title":"Multidrug Resistance After Trabeculectomy With Mitomycin C","status":"COMPLETED","sponsor":"University of Cologne","startDate":"","conditions":"Glaucoma, Trabeculectomy","enrollment":30},{"nctId":"NCT00371072","phase":"PHASE2, PHASE3","title":"Trabeculectomy With MMC Versus Ahmed Glaucoma Implant for Treatment of Pediatric Aphakic Glaucoma","status":"COMPLETED","sponsor":"Shahid Beheshti University of Medical Sciences","startDate":"2004-03","conditions":"Pediatric Aphakic Glaucoma","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Trabeculectomy with MMC","genericName":"Trabeculectomy with MMC","companyName":"Pro Top & Mediking Company Limited","companyId":"pro-top-mediking-company-limited","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trabeculectomy with MMC is a surgical procedure used to treat conditions such as glaucoma, neovascular glaucoma, and primary open angle glaucoma. Mitomycin-C, a small molecule used in this procedure, is administered as an adjunctive therapy before surgery to prevent scarring.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}