{"id":"trabectidin-yondelis","safety":{"commonSideEffects":[{"rate":"80","effect":"Neutropenia"},{"rate":"65","effect":"Thrombocytopenia"},{"rate":"70","effect":"Anemia"},{"rate":"60","effect":"Nausea and vomiting"},{"rate":"55","effect":"Fatigue"},{"rate":"40","effect":"Hepatotoxicity (elevated transaminases)"},{"rate":"5","effect":"Rhabdomyolysis"}]},"_chembl":{"chemblId":"CHEMBL450449","moleculeType":"Small molecule","molecularWeight":"761.85"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Trabectedin is a marine-derived alkaloid that covalently binds to the minor groove of DNA, disrupting transcription-coupled nucleotide excision repair (TC-NER) and blocking cell cycle progression. This mechanism is particularly effective against certain soft tissue sarcomas and ovarian cancers, where it induces apoptosis and also modulates the tumor microenvironment by reducing monocyte infiltration.","oneSentence":"Trabectedin binds to DNA and interferes with transcription and DNA repair, leading to cell cycle arrest and apoptosis in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:28.065Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Soft tissue sarcoma (liposarcoma and leiomyosarcoma)"},{"name":"Relapsed platinum-sensitive ovarian cancer (in combination with pegylated liposomal doxorubicin)"}]},"trialDetails":[{"nctId":"NCT05597917","phase":"PHASE3","title":"tTF-NGR Randomized Study - STS","status":"RECRUITING","sponsor":"Universität Münster","startDate":"2021-10-26","conditions":"Soft Tissue Sarcoma","enrollment":126},{"nctId":"NCT03164980","phase":"PHASE4","title":"QoL-Comparison Between Trabectedin/PLD and Pt-based Therapy in Patients With Pt-sensitive Recurrent Ovarian Cancer","status":"TERMINATED","sponsor":"North Eastern German Society of Gynaecological Oncology","startDate":"2018-02-01","conditions":"Quality of Life, Ovarian Cancer, Recurrent Ovarian Carcinoma","enrollment":89},{"nctId":"NCT04394728","phase":"","title":"Pharmacometabolomic of Trabectedin in Soft Tissue Patients","status":"COMPLETED","sponsor":"Centro di Riferimento Oncologico - Aviano","startDate":"2015-04","conditions":"Sarcoma","enrollment":44},{"nctId":"NCT00060944","phase":"PHASE2","title":"A Study to Assess Treatment With 2 Different Dosing Schedules of Trabectidin Administered to Patients With Advanced Cancer","status":"COMPLETED","sponsor":"Johnson & Johnson Pharmaceutical Research & Development, L.L.C.","startDate":"2003-05","conditions":"Liposarcoma, Leiomyosarcoma","enrollment":271}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Trabectidin (Yondelis)","genericName":"Trabectidin (Yondelis)","companyName":"North Eastern German Society of Gynaecological Oncology","companyId":"north-eastern-german-society-of-gynaecological-oncology","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Trabectedin binds to DNA and interferes with transcription and DNA repair, leading to cell cycle arrest and apoptosis in cancer cells. Used for Soft tissue sarcoma (liposarcoma and leiomyosarcoma), Relapsed platinum-sensitive ovarian cancer (in combination with pegylated liposomal doxorubicin).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}