{"id":"tqb3616-capsules-letrozole-anastrozole-tamoxifen","safety":{"commonSideEffects":[{"rate":"50-80%","effect":"Hot flashes"},{"rate":"30-50%","effect":"Vaginal discharge"},{"rate":"20-40%","effect":"Nausea"},{"rate":"10-30%","effect":"Diarrhea"},{"rate":"10-30%","effect":"Musculoskeletal pain"}]},"_chembl":{"chemblId":"CHEMBL1444","moleculeType":"Small molecule","molecularWeight":"285.31"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"These drugs work by inhibiting the aromatase enzyme, which is responsible for converting androgens to estrogens, thereby reducing estrogen levels in the body. Tamoxifen, on the other hand, binds to estrogen receptors, blocking the action of estrogen in breast tissue.","oneSentence":"Letrozole and Anastrozole are non-steroidal, selective aromatase inhibitors, while Tamoxifen is a selective estrogen receptor modulator.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:39:34.700Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of hormone receptor-positive metastatic breast cancer"},{"name":"Adjuvant treatment of hormone receptor-positive breast cancer"}]},"trialDetails":[{"nctId":"NCT05780567","phase":"PHASE3","title":"Clinical Study on Adjuvant Therapy of TQB3616 Combined With Endocrine Therapy Compared With Placebo Combined With Endocrine Therapy in Patients With Breast Cancer","status":"RECRUITING","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2023-03-30","conditions":"Breast Cancer","enrollment":1946}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"TQB3616 capsules, Letrozole, Anastrozole, Tamoxifen","genericName":"TQB3616 capsules, Letrozole, Anastrozole, Tamoxifen","companyName":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","companyId":"chia-tai-tianqing-pharmaceutical-group-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Letrozole and Anastrozole are non-steroidal, selective aromatase inhibitors, while Tamoxifen is a selective estrogen receptor modulator. Used for Treatment of hormone receptor-positive metastatic breast cancer, Adjuvant treatment of hormone receptor-positive breast cancer.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}