{"id":"tpx-105","safety":{"commonSideEffects":[{"rate":null,"effect":"Local application site reactions"},{"rate":null,"effect":"Transient sensory changes"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TPX-105 targets specific TRP channel subtypes that mediate nociceptive (pain) signaling in peripheral sensory neurons. By blocking these ion channels, the drug reduces the transmission of pain signals to the central nervous system, providing analgesic effects without the systemic side effects associated with opioids or traditional NSAIDs.","oneSentence":"TPX-105 is a selective inhibitor of transient receptor potential (TRP) channels involved in pain signaling.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:39:35.375Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Neuropathic pain (Phase 3)"},{"name":"Chronic pain conditions"}]},"trialDetails":[{"nctId":"NCT06197789","phase":"PHASE3","title":"Safety and Efficacy Study of TPX-105 for Correction of Nasojugal Groove","status":"COMPLETED","sponsor":"Tego Science, Inc.","startDate":"2021-08-18","conditions":"Tear Trough Eyelid Deformity","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Autologous human dermal fibroblasts"],"phase":"phase_3","status":"active","brandName":"TPX-105","genericName":"TPX-105","companyName":"Tego Science, Inc.","companyId":"tego-science-inc","modality":"Biologic","firstApprovalDate":"","aiSummary":"TPX-105 is a selective inhibitor of transient receptor potential (TRP) channels involved in pain signaling. Used for Neuropathic pain (Phase 3), Chronic pain conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}