{"id":"tpo","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Thromboembolic events"}]},"_chembl":{"chemblId":"CHEMBL5400495","moleculeType":null,"molecularWeight":"839.95"},"_dailymed":{"setId":"fce826ab-4d6a-4139-a2ee-a304a913a253","title":"TPOXX (TECOVIRIMAT MONOHYDRATE) INJECTION, SOLUTION, CONCENTRATE TPOXX (TECOVIRIMAT MONOHYDRATE) CAPSULE [SIGA TECHNOLOGIES, INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TPO (thrombopoietin) mimetics work by activating the c-Mpl receptor, which is the physiological receptor for endogenous thrombopoietin. This activation promotes megakaryocyte differentiation and platelet production in the bone marrow. The drug is used to increase platelet counts in patients with thrombocytopenia.","oneSentence":"TPO is a thrombopoietin receptor agonist that stimulates platelet production by binding to and activating the thrombopoietin receptor on hematopoietic stem cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:21.941Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Immune thrombocytopenia (ITP)"},{"name":"Thrombocytopenia associated with chronic liver disease"}]},"trialDetails":[{"nctId":"NCT07113743","phase":"PHASE1, PHASE2","title":"Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous Disease","status":"ENROLLING_BY_INVITATION","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2025-09-10","conditions":"Chronic Granulomatous Disease (CGD)","enrollment":10},{"nctId":"NCT04797000","phase":"PHASE2","title":"Study of Efficacy and Safety of Eltrombopag in 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