{"id":"total-coumarin-tc-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Photosensitivity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Coumarin compounds possess anti-inflammatory, antioxidant, and immunomodulatory properties that help reduce the excessive keratinocyte proliferation and inflammatory cytokine production characteristic of psoriasis. When applied topically, total coumarin extract may suppress T-cell activation and reduce inflammatory mediators in affected skin tissue, thereby improving clinical symptoms and skin barrier function.","oneSentence":"Total coumarin cream reduces skin inflammation and promotes healing in psoriasis through topical anti-inflammatory and antioxidant effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:54:24.047Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Psoriasis (topical treatment)"}]},"trialDetails":[{"nctId":"NCT03372811","phase":"PHASE2","title":"Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-IIb Trial)","status":"COMPLETED","sponsor":"Psoriasis Research Institute of Guangzhou","startDate":"2015-06-11","conditions":"Psoriasis Vulgaris, Topical Administration","enrollment":88},{"nctId":"NCT07426120","phase":"PHASE3","title":"Efficacy and Safety of a Botanical Total Coumarin (TC) Cream in Treating Patients With Psoriasis Vulgaris (PLANTCOAT-III)","status":"RECRUITING","sponsor":"Psoriasis Research Institute of Guangzhou","startDate":"2026-02-01","conditions":"Psoriasis Vulgaris, Topical Administration, Phase III","enrollment":300}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["TC Cream"],"phase":"phase_3","status":"active","brandName":"Total coumarin (TC) cream","genericName":"Total coumarin (TC) cream","companyName":"Psoriasis Research Institute of Guangzhou","companyId":"psoriasis-research-institute-of-guangzhou","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Total coumarin cream reduces skin inflammation and promotes healing in psoriasis through topical anti-inflammatory and antioxidant effects. Used for Psoriasis (topical treatment).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}