{"id":"tot-hema","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset (nausea, constipation, abdominal discomfort)"},{"rate":null,"effect":"Dark stools"},{"rate":null,"effect":"Metallic taste"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The drug provides bioavailable iron in a formulation designed for oral absorption, helping to restore hemoglobin and red blood cell production in patients with iron deficiency. It is typically used when dietary iron intake is insufficient or absorption is impaired.","oneSentence":"TOT'HEMA is an oral iron supplement that replenishes iron stores to treat iron deficiency anemia.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:39:03.027Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Iron deficiency anemia"}]},"trialDetails":[{"nctId":"NCT04309669","phase":"PHASE4","title":"Assessment of the eFficacy, the Onset-of-Action and the Safety of Tot'héma® in Adults With Moderate Iron Deficiency Anaemia","status":"COMPLETED","sponsor":"Laboratoire Innotech International","startDate":"2020-11-12","conditions":"Anemia","enrollment":167}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"LUNG DISORDER"},{"count":1,"reaction":"PANCREATITIS ACUTE"},{"count":1,"reaction":"PULMONARY OEDEMA"},{"count":1,"reaction":"SYNCOPE"},{"count":1,"reaction":"TORSADE DE POINTES"},{"count":1,"reaction":"WHITE BLOOD CELL COUNT INCREASED"}],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"TOT'HEMA","genericName":"TOT'HEMA","companyName":"Laboratoire Innotech International","companyId":"laboratoire-innotech-international","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TOT'HEMA is an oral iron supplement that replenishes iron stores to treat iron deficiency anemia. Used for Iron deficiency anemia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}