{"id":"topiramate-implant","safety":{"commonSideEffects":[{"rate":null,"effect":"Cognitive impairment / memory problems"},{"rate":null,"effect":"Paresthesia"},{"rate":null,"effect":"Weight loss"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Topiramate potentiates the activity of the inhibitory neurotransmitter GABA at GABA-A receptors and antagonizes excitatory glutamate receptors, while also blocking voltage-gated sodium channels. When formulated as an implant, it provides sustained local or systemic drug delivery to maintain therapeutic levels over an extended period. This mechanism reduces abnormal neuronal firing and is used to prevent seizures and manage other neurological conditions.","oneSentence":"Topiramate is a sulfamate-substituted monosaccharide that enhances GABA-mediated inhibition and blocks sodium channels to reduce neuronal excitability.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:38:56.693Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epilepsy / seizure prevention"},{"name":"Migraine prophylaxis"}]},"trialDetails":[{"nctId":"NCT07413731","phase":"","title":"Neurophysiological Effects of Medication Tapering During Treatment With Spinal Cord Stimulation","status":"RECRUITING","sponsor":"Brai²n","startDate":"2025-02-03","conditions":"Persistent Spinal Pain Syndrome Type 2 (PSPS-T2), Lower Spine, Spinal Cord Sensitivity to Neurostimulation, Neurophysiological Sensitivity to Spinal Cord Stimulation","enrollment":50},{"nctId":"NCT07058155","phase":"PHASE4","title":"Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease","status":"RECRUITING","sponsor":"The Cleveland Clinic","startDate":"2025-12-17","conditions":"Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity","enrollment":70},{"nctId":"NCT03307863","phase":"PHASE4","title":"Effect of Anti-epileptic Drugs on Etonogestrel-releasing Implant Pharmacokinetics in Women With Epilepsy","status":"SUSPENDED","sponsor":"University of Sao Paulo","startDate":"2017-11-01","conditions":"Contraception, Drug Interactions","enrollment":69},{"nctId":"NCT03335163","phase":"PHASE1","title":"The Effect of Topiramate on Etonogestrel Concentrations in Contraceptive Implant Users","status":"COMPLETED","sponsor":"University of Colorado, Denver","startDate":"2018-03-15","conditions":"Migraine, Migraine;Menstrual, Contraception","enrollment":48}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Topiramate-Implant","genericName":"Topiramate-Implant","companyName":"University of Sao Paulo","companyId":"university-of-sao-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topiramate is a sulfamate-substituted monosaccharide that enhances GABA-mediated inhibition and blocks sodium channels to reduce neuronal excitability. Used for Epilepsy / seizure prevention, Migraine prophylaxis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}