{"id":"topical-tranexamic-acid","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or erythema"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Minimal systemic absorption with topical application"}]},"_chembl":{"chemblId":"CHEMBL877","moleculeType":"Small molecule","molecularWeight":"157.21"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tranexamic acid is an antifibrinolytic agent that competitively inhibits the conversion of plasminogen to plasmin, thereby reducing fibrin degradation and clot breakdown. When applied topically, it localizes to the wound or affected tissue surface, reducing bleeding and oozing. This mechanism is particularly useful in dermatology for conditions involving abnormal bleeding, vascular lesions, or post-procedural hemostasis.","oneSentence":"Topical tranexamic acid inhibits fibrinolysis by blocking plasminogen activation, reducing bleeding and promoting hemostasis at the site of application.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:21.595Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical hemostasis and reduction of bleeding in dermatological procedures"},{"name":"Melasma and post-inflammatory hyperpigmentation (off-label use)"},{"name":"Rosacea and vascular lesions (investigational)"}]},"trialDetails":[{"nctId":"NCT07495748","phase":"NA","title":"Comparative Evaluation of Topical Metformin and Topical Tranexamic Acid in Melasma","status":"NOT_YET_RECRUITING","sponsor":"Foundation University Islamabad","startDate":"2026-07-01","conditions":"Melasma","enrollment":70},{"nctId":"NCT07455591","phase":"PHASE4","title":"A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement","status":"COMPLETED","sponsor":"Singapore General Hospital","startDate":"2024-01-01","conditions":"Osteo Arthritis of the Knee","enrollment":78},{"nctId":"NCT07448415","phase":"PHASE2, PHASE3","title":"Evaluation of the Efficacy of Oral Tranexamic Acid and Glutathione-assisted Microneedling in Treatment of Melasma","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-02","conditions":"Melasma","enrollment":42},{"nctId":"NCT07434453","phase":"NA","title":"\"Topical Tranexamic Acid With Flap Fixation: A Novel Approach to Minimize Post-operative Drainage and Surgical Site Infection in Patients Undergoing Modified Radical Mastectomy\"","status":"COMPLETED","sponsor":"Noor ul Ain","startDate":"2023-08-04","conditions":"Breast Cancer Females","enrollment":62},{"nctId":"NCT07362992","phase":"EARLY_PHASE1","title":"Topical Tranexamic Acid to Reduce Blood Loss During Cesarean Delivery","status":"NOT_YET_RECRUITING","sponsor":"Wolfson Medical Center","startDate":"2026-01-01","conditions":"Cesarean Delivery, Postpartum Hemorrhage (PPH), Intraoperative Blood Loss","enrollment":112},{"nctId":"NCT07131592","phase":"PHASE4","title":"Effect of Intravenous and Topical Tranexamic Acid on Drain Output in Breast Reduction Surgery","status":"RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2025-11-18","conditions":"Drain Output After Breast Reduction Surgery, Breast Reductions","enrollment":160},{"nctId":"NCT06422273","phase":"PHASE3","title":"Protest Trial: TXA vs Saline","status":"ENROLLING_BY_INVITATION","sponsor":"Corewell Health West","startDate":"2024-04-16","conditions":"Lung Transplant, Complications Surgical","enrollment":94},{"nctId":"NCT05441592","phase":"PHASE4","title":"A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2022-08-15","conditions":"Hematoma Postoperative","enrollment":107},{"nctId":"NCT07202156","phase":"NA","title":"Ultrasound-Enhanced Delivery of Compound TXA Solution in Melasma","status":"RECRUITING","sponsor":"The First Affiliated Hospital with Nanjing Medical University","startDate":"2024-10-20","conditions":"Melasma (Facial Melasma)","enrollment":35},{"nctId":"NCT06379724","phase":"PHASE4","title":"Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft","status":"RECRUITING","sponsor":"University of Kansas Medical Center","startDate":"2024-07-11","conditions":"Burns, Skin Graft Complications","enrollment":62},{"nctId":"NCT05807074","phase":"PHASE4","title":"Impact of Topical Tranexamic Acid in Breast Reconstruction","status":"TERMINATED","sponsor":"University of California, San Francisco","startDate":"2023-04-20","conditions":"Breast Cancer","enrollment":23},{"nctId":"NCT06345833","phase":"EARLY_PHASE1","title":"Topical and Local TXA in Facelifts - A Randomized Controlled Double Blinded Study","status":"RECRUITING","sponsor":"University of Minnesota","startDate":"2024-07-01","conditions":"Hemophilia, Hemorrhage, Facelift Surgery","enrollment":50},{"nctId":"NCT06145191","phase":"NA","title":"Prophylactic Tranexamic Acid Versus Adrenaline During Flexible Bronchoscopy","status":"COMPLETED","sponsor":"Clinical Hospital Centre Zagreb","startDate":"2023-12-18","conditions":"Bleeding, Hemoptysis","enrollment":1013},{"nctId":"NCT07094399","phase":"","title":"Tranexamic Acid for Postpartum Vaginal Laceration Hemorrhage","status":"COMPLETED","sponsor":"Harran University","startDate":"2024-01-01","conditions":"Postpartum Hemorrhage, Vaginal Lacerations","enrollment":161},{"nctId":"NCT03553186","phase":"PHASE3","title":"Tranexamic Acid in Adult Spinal Deformity Surgery","status":"RECRUITING","sponsor":"Hospital for Special Surgery, New York","startDate":"2018-07-11","conditions":"Spinal Deformity, Degenerative Lumbar Spinal Stenosis, Blood Loss, Surgical","enrollment":100},{"nctId":"NCT06644079","phase":"PHASE2","title":"Window of Opportunity Study of Topical Tranexamic Acid for Cutaneous Squamous Cell Carcinoma","status":"WITHDRAWN","sponsor":"University of Florida","startDate":"2025-05","conditions":"Cutaneous Squamous Cell Carcinoma","enrollment":""},{"nctId":"NCT06648265","phase":"PHASE4","title":"EFFECTS OF TRANEXAMIC ACID IN TUMESCENT SOLUTION FOR LIPOSUCTION PROCEDURES","status":"COMPLETED","sponsor":"Total Definer Research Group","startDate":"2022-01-20","conditions":"Liposuction, Bruising, Inflammation","enrollment":78},{"nctId":"NCT02314988","phase":"PHASE2, PHASE3","title":"Tranexamic Acid to Reduce Blood Loss in Spine Surgery","status":"RECRUITING","sponsor":"Columbia University","startDate":"2020-06-15","conditions":"Spinal Injuries, Spinal Deformity","enrollment":252},{"nctId":"NCT04797156","phase":"EARLY_PHASE1","title":"Combined IV and Topical TXA in Major Spine Surgery","status":"COMPLETED","sponsor":"Icahn School of Medicine at Mount Sinai","startDate":"2021-03-03","conditions":"Spine Surgery, Back Pain","enrollment":65},{"nctId":"NCT05357079","phase":"EARLY_PHASE1","title":"Impact of Topical Tranexamic Acid on Pre- and Post-operative Hemoglobin/Hematocrit","status":"COMPLETED","sponsor":"University of Cincinnati","startDate":"2017-08-25","conditions":"Fracture of Posterior Wall of Acetabulum","enrollment":94},{"nctId":"NCT06384456","phase":"PHASE4","title":"Topical TRanexamic Acid Vs. Placebo on Acute Postoperative Pain Following DRF Fixation","status":"NOT_YET_RECRUITING","sponsor":"University Health Network, Toronto","startDate":"2025-03","conditions":"Distal Radius Fractures","enrollment":90},{"nctId":"NCT06205615","phase":"PHASE2","title":"Treatment of Post-Punch Biopsy Bleeding in Apixaban-Treated Patients Using Self-Administered BXP154B","status":"COMPLETED","sponsor":"Bio 54, LLC","startDate":"2024-01-24","conditions":"Wound Bleeding","enrollment":24},{"nctId":"NCT06876181","phase":"","title":"In Vivo Study of Local Tranexamic Acid Concentrations Following Intra-Articular Administration in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Valdoltra Orthopedic Hospital","startDate":"2022-08-23","conditions":"Local Concentration of Tranexamic Acid Following Intra-articular Administration in TKA","enrollment":48},{"nctId":"NCT05554211","phase":"PHASE2","title":"Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage","status":"WITHDRAWN","sponsor":"Northwestern University","startDate":"2022-07-12","conditions":"Breast Cancer, BRCA Mutation","enrollment":""},{"nctId":"NCT06270407","phase":"PHASE4","title":"The Effect of Local Application of Tranexamic Acid Versus Placebo on Postoperative Complications in Plastic Surgery","status":"RECRUITING","sponsor":"St. Olavs Hospital","startDate":"2024-10-01","conditions":"Surgical Complication","enrollment":3000},{"nctId":"NCT04541303","phase":"EARLY_PHASE1","title":"Topical Tranexamic Acid Use on Granulating Wounds Following Mohs Micrographic Surgery","status":"COMPLETED","sponsor":"University of Missouri-Columbia","startDate":"2020-10-08","conditions":"Postoperative Wound Haemorrhage","enrollment":124},{"nctId":"NCT06289478","phase":"NA","title":"Efficacy and Safety of Retrograde Intraarticular Injection, Topical Soaking of Tranexamic Acid (TXA), or Placebo in Femoral Neck Fractured Patients Undergoing Cementless Bipolar Hemiarthroplasty","status":"RECRUITING","sponsor":"King Chulalongkorn Memorial Hospital","startDate":"2024-07-03","conditions":"Femoral Neck Fracture","enrollment":75},{"nctId":"NCT05326997","phase":"NA","title":"Treatment of Melasma With Yellow Light Compared to Tranexamic Acid","status":"TERMINATED","sponsor":"University of Nove de Julho","startDate":"2023-05-01","conditions":"Melasma","enrollment":21},{"nctId":"NCT06522984","phase":"NA","title":"Fractional Erbium YAG Laser vs Intradermal and Systemic Tranexamic Acid","status":"RECRUITING","sponsor":"Egymedicalpedia","startDate":"2024-06-01","conditions":"Refractory Melasma","enrollment":45},{"nctId":"NCT06515535","phase":"NA","title":"Efficacy of Topical Tranexamic Acid in Reducing Blood Loss During CS in Patients With Placenta Previa","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2024-07-24","conditions":"Placenta Previa","enrollment":56},{"nctId":"NCT04814433","phase":"PHASE4","title":"Evaluating Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation","status":"TERMINATED","sponsor":"NYU Langone Health","startDate":"2021-03-24","conditions":"Opioid Pain Medication","enrollment":46},{"nctId":"NCT06427850","phase":"NA","title":"Effect of Topical Tranexamic Acid on Postoperative Drainage in Minimally Invasive Transforaminal Lumbar Interbody Fusion (MI-TLIF)","status":"NOT_YET_RECRUITING","sponsor":"Thanawan Longsuwan","startDate":"2024-07-01","conditions":"Degenerative Spine Diseases, Surgical Wound","enrollment":28},{"nctId":"NCT06418568","phase":"NA","title":"Efficacy and Safety Trial of Using Ultra-Pulsed Shockwaves to Deliver Tranexamic Acid for the Treatment of Melasma","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2024-04-01","conditions":"Chloasma","enrollment":60},{"nctId":"NCT06188052","phase":"PHASE4","title":"Efficacy of Topical Versus Intravenous Tranexamic Acid in Controlling Blood Loss","status":"UNKNOWN","sponsor":"Kasr El Aini Hospital","startDate":"2023-08-01","conditions":"To Calculate Total Blood Loss Immediately Postoperative","enrollment":45},{"nctId":"NCT06183918","phase":"PHASE4","title":"Tranexamic Acid Dosage for Topical Treatment of Anterior Epistaxis","status":"COMPLETED","sponsor":"Izmir Ataturk Training and Research Hospital","startDate":"2021-12-16","conditions":"Anterior Epistaxis, Tranexamic Acid","enrollment":152},{"nctId":"NCT03954314","phase":"PHASE3","title":"DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery","status":"TERMINATED","sponsor":"Population Health Research Institute","startDate":"2019-09-17","conditions":"Bleeding, Surgical Blood Loss, Seizures","enrollment":3242},{"nctId":"NCT06149091","phase":"EARLY_PHASE1","title":"Control of Iatrogenic Endobronchial Bleeding by Tranexamic Acid, Adrenalin and Hemagglutinase","status":"UNKNOWN","sponsor":"China-Japan Friendship Hospital","startDate":"2023-12-01","conditions":"Iatrogenic Endobronchial Bleeding","enrollment":300},{"nctId":"NCT02918201","phase":"PHASE2","title":"The Effect of Topical Tranexamic Acid on Postoperative Bleeding From Superficial Wounds","status":"COMPLETED","sponsor":"St. Olavs Hospital","startDate":"2020-01-01","conditions":"Postoperative Hemorrhage, Injuries and Wounds","enrollment":36},{"nctId":"NCT06010810","phase":"PHASE3","title":"The Effectiveness of 3% Topical Tranexamic Acid Compared to 4% Topical Hydroquinone as Therapy of Melasma","status":"UNKNOWN","sponsor":"Indonesia University","startDate":"2023-06-01","conditions":"Melasma","enrollment":20},{"nctId":"NCT05911698","phase":"NA","title":"Fractional co2 Laser Followed by Either Vitamin c or Tranexamic Acid in Treatment of Melasma.","status":"UNKNOWN","sponsor":"Khadija Qenawi","startDate":"2023-10-28","conditions":"Melasma","enrollment":25},{"nctId":"NCT04766996","phase":"PHASE4","title":"PROUD Study - Preventing Opioid Use Disorders","status":"TERMINATED","sponsor":"Emory University","startDate":"2021-05-17","conditions":"Anesthesia, Opioid Use","enrollment":57},{"nctId":"NCT05897918","phase":"NA","title":"Tranexamic Acid in Treatment of Facial Erythema","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2020-08-01","conditions":"Patient With Facial Erythema","enrollment":50},{"nctId":"NCT05887219","phase":"PHASE1","title":"Comparison of Azelaic Acid 20 % Cream Versus Hydroquinone 4% Cream as an Adjuvant to Oral Tranexamic Acid in Melasma","status":"COMPLETED","sponsor":"Combined Military Hospital Abbottabad","startDate":"2022-11-01","conditions":"Melasma","enrollment":50},{"nctId":"NCT05874583","phase":"NA","title":"Prevention of Bleeding in Total Joint Replacement: Combined Route Administration of Tranexamic Acid","status":"COMPLETED","sponsor":"Mongi Slim Hospital","startDate":"2021-12-01","conditions":"Tranexamic Acid, Arthroplasty, Replacement, Knee, Blood Transfusion","enrollment":100},{"nctId":"NCT05489185","phase":"PHASE4","title":"Clinical Trial to Assess the Efficacy of Tranexamic Acid in Reducing Blood Loss in Hip Fracture Patients.","status":"UNKNOWN","sponsor":"Biogipuzkoa Health Research Institute","startDate":"2023-05-30","conditions":"Hip Fractures","enrollment":644},{"nctId":"NCT03361345","phase":"PHASE2, PHASE3","title":"Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris","status":"WITHDRAWN","sponsor":"Wayne State University","startDate":"2018-11-01","conditions":"Postinflammatory Hyperpigmentation","enrollment":""},{"nctId":"NCT05248321","phase":"NA","title":"Precise Delivery of Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding","status":"COMPLETED","sponsor":"National Cheng-Kung University Hospital","startDate":"2022-03-24","conditions":"Peptic Ulcer Hemorrhage","enrollment":60},{"nctId":"NCT05841251","phase":"NA","title":"Phenylephrine Versus Tranexamic Acid to Control Bleeding in Patients Undergoing Inferior Turbinoplasty by Coblation","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2023-05-01","conditions":"Intraoperative Bleeding, Coblation Turbinoplasty","enrollment":80},{"nctId":"NCT01370460","phase":"PHASE2","title":"Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2011-06","conditions":"Acute Blood Loss Anemia, Osteoarthritis, Knee","enrollment":101},{"nctId":"NCT04947514","phase":"PHASE4","title":"Use of Tranexamic Acid in Reduction Mammoplasty","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2021-10-29","conditions":"Hematoma Postoperative, Venous Thromboembolism","enrollment":98},{"nctId":"NCT03778242","phase":"NA","title":"Tranexamic Acid in Pregnant Women Undergoing Cesarean Section.","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2019-01-01","conditions":"Cesarean Section Complications","enrollment":180},{"nctId":"NCT01683955","phase":"PHASE1","title":"Topical Tranexamic Acid and Acute Blood Loss in Total Hip Arthroplasty","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2013-01-01","conditions":"Acute Blood Loss Anemia, Osteoarthritis, Hip","enrollment":139},{"nctId":"NCT05708690","phase":"PHASE4","title":"Topical Effect of Tranexamic Acid in Postoperative Bleeding and Blood Products Transfusion After Cardiac Surgery","status":"COMPLETED","sponsor":"Indonesia University","startDate":"2022-10-01","conditions":"Coronary Artery Disease, Valvular Heart Disease, Surgical Blood Loss","enrollment":132},{"nctId":"NCT04696224","phase":"NA","title":"Comparative Use of Tranexamic Acid Intravenous and Topical Application in Intertrochanteric Fractures With PFNA","status":"UNKNOWN","sponsor":"Universidade do Vale do Sapucai","startDate":"2020-12-18","conditions":"Hemorrhage, Fracture Femur","enrollment":90},{"nctId":"NCT05326139","phase":"PHASE4","title":"Topical Tranexamic Acid Application in Rhinoplasty","status":"COMPLETED","sponsor":"Baskent University","startDate":"2021-06-07","conditions":"Ecchymosis; Eyelid, Edema, Rhinoplasty","enrollment":50},{"nctId":"NCT04918576","phase":"PHASE3","title":"Topical Tranexamic Acid for Bilateral Breast Reduction Surgery","status":"UNKNOWN","sponsor":"McMaster University","startDate":"2022-08","conditions":"Hematoma Postoperative, Tranexamic Acid","enrollment":106},{"nctId":"NCT04918589","phase":"PHASE3","title":"Tranexamic Acid for Alloplastic Breast Reconstruction","status":"UNKNOWN","sponsor":"McMaster University","startDate":"2022-08","conditions":"Hematoma Postoperative, Breast Cancer, Tranexamic Acid","enrollment":106},{"nctId":"NCT04771923","phase":"NA","title":"Tranexamic Acid Versus Adrenaline for Controlling Iatrogenic Endobronchial Bleeding","status":"COMPLETED","sponsor":"Clinical Hospital Centre Zagreb","startDate":"2021-02-22","conditions":"Bleeding, Hemoptysis","enrollment":130},{"nctId":"NCT05152186","phase":"PHASE3","title":"Compare Between the Effect of Topical Tranexamic Acid Versus Hydrogen Peroxide on Blood Loss in Spine Surgeries","status":"UNKNOWN","sponsor":"Minia University","startDate":"2021-06-01","conditions":"Blood Loss","enrollment":120},{"nctId":"NCT02930941","phase":"PHASE4","title":"Topical Intranasal Tranexamic Acid for Epistaxis in the Emergency Department","status":"TERMINATED","sponsor":"University of California, Davis","startDate":"2016-02","conditions":"Epistaxis","enrollment":35},{"nctId":"NCT05072873","phase":"NA","title":"Topical Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women With Twin Pregnancy","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2021-10-01","conditions":"Cesarean Section Complications","enrollment":150},{"nctId":"NCT05072860","phase":"NA","title":"Topical Tranexamic Acid for the Prevention of Postpartum Hemorrhage in Women Undergoing Elective Cesarean Section","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2021-10-01","conditions":"Cesarean Section Complications","enrollment":150},{"nctId":"NCT02496364","phase":"NA","title":"Evaluation of Topical and Intravenous Tranexamic Acid in Surgical Treatment of Lumbar Degenerative Disease","status":"WITHDRAWN","sponsor":"Vinicius Magno da Rocha, MD, MSc","startDate":"2014-03-01","conditions":"Lumbar Disc Degeneration, Surgical Procedure, Unspecified","enrollment":""},{"nctId":"NCT03328832","phase":"PHASE4","title":"Combined Topical Tranexamic Acid With Floseal® in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Chang Gung Memorial Hospital","startDate":"2017-09-12","conditions":"Osteoarthritis, Knee","enrollment":70},{"nctId":"NCT03570710","phase":"NA","title":"Reducing Blood Loss During Cesarean Hysterectomy for Placenta Accreta Spectrum","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2018-01-01","conditions":"Cesarean Section Complications","enrollment":80},{"nctId":"NCT02664909","phase":"PHASE4","title":"Topical (Intra-Articular) Tranexamic Acid and Transfusion Rates Following Hip Hemiarthroplasty","status":"COMPLETED","sponsor":"UConn Health","startDate":"2016-01-01","conditions":"Femoral Neck Fractures","enrollment":36},{"nctId":"NCT02650856","phase":"PHASE3","title":"Blood Loss Reduction After Total Knee Arthroplasty. Comparison Topical Tranexamic Acid vs Platelet Rich Plasma","status":"COMPLETED","sponsor":"Universidad Autonoma de Nuevo Leon","startDate":"2015-09","conditions":"Osteoarthritis","enrollment":40},{"nctId":"NCT02877381","phase":"PHASE4","title":"Tranexamic Acid in Revision Total Joint Arthroplasty","status":"COMPLETED","sponsor":"Rush University Medical Center","startDate":"2016-04","conditions":"Revision Total Knee Arthroplasty, Revision Total Hip Arthroplasty, Acute Blood Loss Anemia","enrollment":175},{"nctId":"NCT03738527","phase":"PHASE4","title":"SEroma Reduction pOst MAstectomy \"SEROMA Study\"","status":"UNKNOWN","sponsor":"Hamilton Health Sciences Corporation","startDate":"2019-10-07","conditions":"Seroma Complicating A Procedure, Hematoma Postoperative, Breast Cancer","enrollment":100},{"nctId":"NCT03376061","phase":"PHASE4","title":"Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery","status":"COMPLETED","sponsor":"Population Health Research Institute","startDate":"2017-12-21","conditions":"Bleeding, Surgical Blood Loss","enrollment":97},{"nctId":"NCT04697992","phase":"NA","title":"Topical Tranexamic Acid Versus Topical Vitamin C With Microneedling in Periorbital Hyperpigmentation; Comparative Study","status":"COMPLETED","sponsor":"Kasr El Aini Hospital","startDate":"2019-11-01","conditions":"Periorbital Hyperpigmentation","enrollment":60},{"nctId":"NCT01622946","phase":"PHASE4","title":"The Effect of Topical Application of Tranexamic Acid in Total Hip Arthroplasty Through the Direct Anterior Approach","status":"COMPLETED","sponsor":"Universitaire Ziekenhuizen KU Leuven","startDate":"2012-04","conditions":"Total Hip Arthroplasty, Postoperative Blood Loss","enrollment":80},{"nctId":"NCT04599205","phase":"PHASE2, PHASE3","title":"Evaluation of Laser and Tranexamic Acid in Treatment of Melasma","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-12","conditions":"Melasma","enrollment":40},{"nctId":"NCT04312880","phase":"PHASE4","title":"Tranexamic Acid Infusion During Elective Spine Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"Albany Medical College","startDate":"2018-12-01","conditions":"Spine Surgery","enrollment":65},{"nctId":"NCT03706339","phase":"NA","title":"Reducing Blood Loss During Cesarean Section by Topical Versus IV Tranexamic Acid","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2018-11-01","conditions":"Cesarean Section Complications","enrollment":450},{"nctId":"NCT04400916","phase":"NA","title":"Topical Tranexamic Acid After Intravitreal Injections","status":"UNKNOWN","sponsor":"Rambam Health Care Campus","startDate":"2020-09","conditions":"Subconjunctival Hemorrhage","enrollment":100},{"nctId":"NCT02278263","phase":"PHASE4","title":"Tranexamic Acid in Knee Joint Surgery","status":"COMPLETED","sponsor":"Andrew G Hill, MBChB, MD (Thesis), EdD, FACS, FRACS","startDate":"2014-12","conditions":"Osteoarthritis","enrollment":150},{"nctId":"NCT02627560","phase":"PHASE4","title":"The Effect of Topical Tranexamic Acid on Bleeding and Seroma Formation in After Undergoing Mastectomy","status":"COMPLETED","sponsor":"St. Olavs Hospital","startDate":"2016-01","conditions":"Postoperative Hemorrhage, Breast Neoplasms, Seroma","enrollment":202},{"nctId":"NCT01937559","phase":"PHASE4","title":"Topical Tranexamic Acid (TXA) in Joint Arthroplasty","status":"COMPLETED","sponsor":"The Hawkins Foundation","startDate":"2013-04","conditions":"Osteoarthritis, Hip Arthropathy, Shoulder Arthropathy","enrollment":188},{"nctId":"NCT04188184","phase":"NA","title":"Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy","status":"COMPLETED","sponsor":"Assiut University","startDate":"2019-12-04","conditions":"Intraoperative Bleeding","enrollment":60},{"nctId":"NCT02540226","phase":"PHASE4","title":"Effect of Topical and Intravenous Tranexamic Acid (TXA) on Thrombogenic Markers in Patients Undergoing Knee Replacement","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2015-11-19","conditions":"Osteoarthritis, Knee","enrollment":76},{"nctId":"NCT03505502","phase":"NA","title":"Reducing Blood Loss During Cesarean Myomectomy With Tranexamic Acid","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2018-01-01","conditions":"Cesarean Section Complications","enrollment":120},{"nctId":"NCT03386656","phase":"PHASE3","title":"Efficacy and Safety of Topical Application of Tranexamic Acid for Saving Blood Losses in Patients Subjected to Prosthetic Knee Surgery","status":"COMPLETED","sponsor":"Fundación Pública Andaluza Progreso y Salud","startDate":"2017-11-28","conditions":"Osteoarthritis, Knee","enrollment":150},{"nctId":"NCT03623789","phase":"PHASE4","title":"Blood-saving Effect of Combined Intravenous Tranexamic Acid With Topical Floseal® Application Total Hip Arthroplasty","status":"UNKNOWN","sponsor":"Chang Gung Memorial Hospital","startDate":"2018-08-15","conditions":"Hip Replacement, Total","enrollment":90},{"nctId":"NCT03923062","phase":"PHASE4","title":"Different Dermatological Approaches the Treatment of Melasma","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-02-01","conditions":"Melasma","enrollment":40},{"nctId":"NCT01940523","phase":"PHASE4","title":"Randomized Controlled Trial of Tranexamic Acid in Total Knee Arthroplasty: Intravenous vs. Topical","status":"COMPLETED","sponsor":"Hospital for Special Surgery, New York","startDate":"2013-05","conditions":"Osteoarthritis","enrollment":640},{"nctId":"NCT02993341","phase":"PHASE3","title":"Topical Tranexamic Acid (TXA) in Hip Fractures","status":"COMPLETED","sponsor":"Sault Area Hospital","startDate":"2016-11","conditions":"Hip Fracture, Anemia","enrollment":65},{"nctId":"NCT03101124","phase":"PHASE2","title":"Serum Concentration of Tranexamic Acid After Topical Administration in Massive Weight Loss Skin Reducing Surgery","status":"COMPLETED","sponsor":"St. Olavs Hospital","startDate":"2017-05-01","conditions":"Surgical Wound, Bleeding","enrollment":36},{"nctId":"NCT01964781","phase":"PHASE4","title":"The Effect of Topical Administration of Common Drugs on Postoperative Bleeding and Pain","status":"COMPLETED","sponsor":"St. Olavs Hospital","startDate":"2013-08","conditions":"Pain, Postoperative, Postoperative Hemorrhage","enrollment":30},{"nctId":"NCT03880045","phase":"NA","title":"Topical Tranexamic Acid Plus Perivascular Vasopressin at the Time of Abdominal Myomectomy","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2019-04-01","conditions":"Myoma","enrollment":100},{"nctId":"NCT03741075","phase":"NA","title":"Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2018-12-01","conditions":"Cesarean Section Complications","enrollment":100},{"nctId":"NCT01727843","phase":"PHASE3","title":"Topical Application of Tranexamic Acid and Postoperative Blood Loss in Femoral Neck Fractures","status":"TERMINATED","sponsor":"Dr. Jeff Yach","startDate":"2013-04","conditions":"Femoral Neck Fracture","enrollment":15},{"nctId":"NCT03751163","phase":"PHASE3","title":"Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma","status":"COMPLETED","sponsor":"Fakultas Kedokteran Universitas Indonesia","startDate":"2016-03-16","conditions":"Melasma","enrollment":50},{"nctId":"NCT03585179","phase":"PHASE3","title":"Oral and Topical Tranexamic Acid for the Treatment of Melasma","status":"UNKNOWN","sponsor":"Centro Dermatológico Dr. Ladislao de la Pascua","startDate":"2018-08-01","conditions":"Melasma, Chloasma, Melanosis","enrollment":120},{"nctId":"NCT02219152","phase":"PHASE2","title":"Topical Instillation of Tranexamic Aacid in Bronchoscopy to Decrease Bleeding During Entobronchial & Transbronchial Biopsiy: a Prospective Double Blind Placebo Controlled Study","status":"UNKNOWN","sponsor":"Liran Levy","startDate":"2014-09","conditions":"Bronchoscopy Biopsy","enrollment":120},{"nctId":"NCT02644473","phase":"PHASE4","title":"Safety of Topical Tranexamic Acid in Total Joint Arthroplasty in High Risk Patients","status":"WITHDRAWN","sponsor":"Albert Einstein College of Medicine","startDate":"2016-02","conditions":"Pulmonary Embolism, Deep Vein Thrombosis, Stroke","enrollment":""},{"nctId":"NCT02393300","phase":"PHASE3","title":"Comparison of Topical Versus Intravenous Tranexamic Acid in TKA","status":"COMPLETED","sponsor":"Shanghai Jiao Tong University School of Medicine","startDate":"2014-07","conditions":"Total Blood Loss","enrollment":174},{"nctId":"NCT01866943","phase":"PHASE2","title":"Role of Topical Tranexamic Acid in Total Hip Arthroplasty","status":"TERMINATED","sponsor":"Northwell Health","startDate":"2011-11","conditions":"Post Operative Blood Loss","enrollment":41},{"nctId":"NCT03244423","phase":"PHASE2","title":"Tranexamic Acid in Cyanotic Heart Defects","status":"COMPLETED","sponsor":"Assiut University","startDate":"2009-01","conditions":"Postoperative Hemorrhage","enrollment":120},{"nctId":"NCT03044041","phase":"PHASE4","title":"Comparison Between Low Dose and High Dose Intra-articular Tranexamic Acid in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Thammasat University","startDate":"2016-01","conditions":"Blood Loss, Surgical","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":330,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["active comparator","Active Comparator","experimental","TXA group","Topical transamine"],"phase":"marketed","status":"active","brandName":"Topical tranexamic acid","genericName":"Topical tranexamic acid","companyName":"Aswan University Hospital","companyId":"aswan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical tranexamic acid has been studied as a treatment for various conditions, including postoperative blood loss, hematoma, and venous thromboembolism, as well as for cosmetic conditions such as melasma and skin hyperpigmentation after total hip arthroplasty. It has been tested in clinical trials using different formulations, including 3% topical tranexamic acid, compared to placebo or other interventions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":6,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}