{"id":"topical-ta","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Striae"},{"rate":null,"effect":"Telangiectasia"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":null,"_dailymed":{"setId":"4dc2850a-9a7e-660f-e063-6294a90afd94","title":"TACRUITF 5% MINOXIDIL WITH BIOTIN TOPICAL SOLUTION (MINOXIDIL) SOLUTION [GUANGZHOU BORDERLESS TECHNOLOGY CO., LTD.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Triamcinolone acetonide binds to glucocorticoid receptors in skin cells, reducing the production of inflammatory cytokines and mediators. This leads to decreased inflammation, itching, and immune cell infiltration at the site of application. It is used for localized dermatological conditions where anti-inflammatory and immunosuppressive effects are therapeutically beneficial.","oneSentence":"Topical TA (triamcinolone acetonide) is a corticosteroid that suppresses local inflammatory and immune responses when applied to the skin.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T06:29:29.405Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and pruritic dermatological conditions (e.g., eczema, psoriasis, dermatitis)"},{"name":"Localized skin inflammation and allergic reactions"}]},"trialDetails":[{"nctId":"NCT07137819","phase":"PHASE3","title":"Phase 3 - Evaluation of Veregen® 10% Ointment as New Herbal Topical Treatment for Actinic Keratosis","status":"RECRUITING","sponsor":"Aresus Pharma GmbH","startDate":"2024-09-04","conditions":"Actinic Keratosis of Face and Scalp","enrollment":280},{"nctId":"NCT05158699","phase":"PHASE3","title":"Effectiveness of Periocular Drug Injection in CATaract Surgery","status":"TERMINATED","sponsor":"Luigi Rondas","startDate":"2021-10-13","conditions":"Macular Edema, Cystoid Macular Edema, Retinal Disease","enrollment":628},{"nctId":"NCT04056962","phase":"PHASE2","title":"Tacrolimus for the Treatment of Superficial Kaposiform Hemangioendothelioma and Tufted Angioma","status":"RECRUITING","sponsor":"West China Hospital","startDate":"2019-09-01","conditions":"Tacrolimus, Kaposiform Hemangioendothelioma, Tufted Angioma","enrollment":50},{"nctId":"NCT00788164","phase":"PHASE1","title":"Vaccine Therapy With or Without Imiquimod in Treating Patients With Grade 3 Cervical Intraepithelial Neoplasia","status":"COMPLETED","sponsor":"Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins","startDate":"2008-11","conditions":"Cervical Cancer, Precancerous Condition, HPV Disease","enrollment":75},{"nctId":"NCT03778242","phase":"NA","title":"Tranexamic Acid in Pregnant Women Undergoing Cesarean Section.","status":"COMPLETED","sponsor":"Aswan University Hospital","startDate":"2019-01-01","conditions":"Cesarean Section Complications","enrollment":180},{"nctId":"NCT05326139","phase":"PHASE4","title":"Topical Tranexamic Acid Application in Rhinoplasty","status":"COMPLETED","sponsor":"Baskent University","startDate":"2021-06-07","conditions":"Ecchymosis; Eyelid, Edema, Rhinoplasty","enrollment":50},{"nctId":"NCT02240407","phase":"PHASE1","title":"Re-administration of Intramuscular AAV9 in Patients With Late-Onset Pompe Disease","status":"COMPLETED","sponsor":"University of Florida","startDate":"2017-10-17","conditions":"Pompe Disease","enrollment":2},{"nctId":"NCT03376061","phase":"PHASE4","title":"Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery","status":"COMPLETED","sponsor":"Population Health Research Institute","startDate":"2017-12-21","conditions":"Bleeding, Surgical Blood Loss","enrollment":97},{"nctId":"NCT03880045","phase":"NA","title":"Topical Tranexamic Acid Plus Perivascular Vasopressin at the Time of Abdominal Myomectomy","status":"UNKNOWN","sponsor":"Aswan University Hospital","startDate":"2019-04-01","conditions":"Myoma","enrollment":100},{"nctId":"NCT03751163","phase":"PHASE3","title":"Oral Tranexamic Acid and Topical Hydroquinone in the Treatment of Melasma","status":"COMPLETED","sponsor":"Fakultas Kedokteran Universitas Indonesia","startDate":"2016-03-16","conditions":"Melasma","enrollment":50},{"nctId":"NCT02973581","phase":"NA","title":"SPI-directed Analgesia for Vitreoretinal Surgeries","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2016-02","conditions":"Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain","enrollment":176},{"nctId":"NCT01895101","phase":"PHASE4","title":"The Effect on Blood Loss of Topical and Intravenous Tranexamic Acid in Cardiac Surgery Patients","status":"COMPLETED","sponsor":"Amphia Hospital","startDate":"2013-10","conditions":"Blood Loss, Tranexamic Acid, Cardiac Surgery","enrollment":750},{"nctId":"NCT01600599","phase":"NA","title":"Reducing Post Operative Bleeding Following Cabg","status":"COMPLETED","sponsor":"University of Malaya","startDate":"2011-01","conditions":"Post CABG Bleeding","enrollment":40},{"nctId":"NCT00985920","phase":"PHASE4","title":"Topical Tranexamic Acid for Total Knee Arthroplasty","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2007-09","conditions":"Surgical Blood Loss, Total Knee Arthroplasty","enrollment":125}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":33,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Active comparator"],"phase":"marketed","status":"active","brandName":"Topical TA","genericName":"Topical TA","companyName":"Aswan University Hospital","companyId":"aswan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical TA (triamcinolone acetonide) is a corticosteroid that suppresses local inflammatory and immune responses when applied to the skin. Used for Inflammatory and pruritic dermatological conditions (e.g., eczema, psoriasis, dermatitis), Localized skin inflammation and allergic reactions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}