{"id":"topical-sertaconazole-2","safety":{"commonSideEffects":[{"rate":null,"effect":"Contact dermatitis"},{"rate":null,"effect":"Local irritation or burning"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL1201196","moleculeType":"Small molecule","molecularWeight":"437.78"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As an imidazole antifungal, sertaconazole binds to the cytochrome P450-dependent enzyme lanosterol 14α-demethylase in fungi, blocking the conversion of lanosterol to ergosterol. This disrupts the integrity and permeability of the fungal cell membrane, leading to cell death. The topical formulation delivers high local concentrations to skin and nail infections while minimizing systemic exposure.","oneSentence":"Sertaconazole inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:13:14.259Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical fungal infections (dermatophytes, Candida species, and other susceptible fungi)"},{"name":"Tinea pedis, tinea corporis, tinea cruris, and cutaneous candidiasis"}]},"trialDetails":[{"nctId":"NCT06869681","phase":"PHASE4","title":"Efficacy of Tropical Sertaconazole Nitrate 2% Vs Clotrimazole 1% for Tinea Pedis","status":"NOT_YET_RECRUITING","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2025-03-01","conditions":"Tinea Pedis","enrollment":100},{"nctId":"NCT00856596","phase":"PHASE3","title":"Once a Day Topical Treatment for Athlete's Foot Fungus Inbetween the Toes in Males and Females","status":"UNKNOWN","sponsor":"Jamaica Hospital Medical Center","startDate":"2009-03","conditions":"Tinea Pedis, Athlete's Foot, Foot Fungus","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Topical Sertaconazole 2%","genericName":"Topical Sertaconazole 2%","companyName":"Jinnah Postgraduate Medical Centre","companyId":"jinnah-postgraduate-medical-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Sertaconazole inhibits fungal lanosterol 14α-demethylase, disrupting ergosterol synthesis in the fungal cell membrane. Used for Topical fungal infections (dermatophytes, Candida species, and other susceptible fungi), Tinea pedis, tinea corporis, tinea cruris, and cutaneous candidiasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}