{"id":"topical-pexiganan-cream-0-8","safety":{"commonSideEffects":[{"rate":null,"effect":"Application site reactions (erythema, irritation)"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Pain or burning at application site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Pexiganan mimics naturally occurring antimicrobial peptides and works by inserting into and destabilizing bacterial cell membranes, leading to cell lysis and death. Unlike conventional antibiotics that target specific bacterial enzymes or pathways, this mechanism makes it effective against multidrug-resistant organisms. The peptide's broad-spectrum activity and novel mechanism make it particularly useful for topical wound and skin infections.","oneSentence":"Pexiganan is an antimicrobial peptide that disrupts bacterial cell membranes, killing a broad spectrum of bacteria including antibiotic-resistant strains.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:39:25.231Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diabetic foot ulcers"},{"name":"Infected wounds and skin infections"}]},"trialDetails":[{"nctId":"NCT01590758","phase":"PHASE3","title":"Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers","status":"COMPLETED","sponsor":"Dipexium Pharmaceuticals, Inc.","startDate":"2014-06","conditions":"Diabetic Foot Infection","enrollment":189},{"nctId":"NCT01594762","phase":"PHASE3","title":"Pexiganan Versus Placebo Control for the Treatment of Mild Infections of Diabetic Foot Ulcers","status":"COMPLETED","sponsor":"Dipexium Pharmaceuticals, Inc.","startDate":"2014-06","conditions":"Diabetic Foot Infection","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["MSI-78"],"phase":"phase_3","status":"active","brandName":"Topical pexiganan cream 0.8%","genericName":"Topical pexiganan cream 0.8%","companyName":"Dipexium Pharmaceuticals, Inc.","companyId":"dipexium-pharmaceuticals-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pexiganan is an antimicrobial peptide that disrupts bacterial cell membranes, killing a broad spectrum of bacteria including antibiotic-resistant strains. Used for Diabetic foot ulcers, Infected wounds and skin infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}