{"id":"topical-organogel-with-nitroglycerin","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Local skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Nitroglycerin is a nitrate vasodilator that is bioconverted to nitric oxide, which activates guanylate cyclase and increases cGMP levels in vascular smooth muscle, leading to vasodilation. The organogel formulation provides sustained topical delivery of nitroglycerin to affected tissues, improving local blood perfusion. This mechanism is used to treat conditions characterized by reduced blood flow or vascular dysfunction.","oneSentence":"Nitroglycerin releases nitric oxide to dilate blood vessels and improve blood flow when applied topically as an organogel formulation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:39:23.474Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical vasodilation for improved blood flow (specific indication under investigation in phase 3)"}]},"trialDetails":[{"nctId":"NCT00266669","phase":"PHASE3","title":"Phase III Study of Topical Gel for Treatment and Prevention of Raynaud's Phenomenon","status":"COMPLETED","sponsor":"MediQuest Therapeutics","startDate":"2005-12","conditions":"Raynaud's Disease","enrollment":200},{"nctId":"NCT00253331","phase":"PHASE2, PHASE3","title":"Lab Study of MQX-503 in Treatment of Raynaud's","status":"COMPLETED","sponsor":"MediQuest Therapeutics","startDate":"2004-11","conditions":"Raynaud Disease, Raynaud Disease Secondary to Scleroderma, Raynaud Secondary to Other Autoimmune Disease","enrollment":36}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Topical organogel with nitroglycerin","genericName":"Topical organogel with nitroglycerin","companyName":"MediQuest Therapeutics","companyId":"mediquest-therapeutics","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Nitroglycerin releases nitric oxide to dilate blood vessels and improve blood flow when applied topically as an organogel formulation. Used for Topical vasodilation for improved blood flow (specific indication under investigation in phase 3).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}