{"id":"topical-lyophilized-exosomes-application","safety":{"commonSideEffects":[]},"_chembl":{"chemblId":"CHEMBL2108694","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Exosomes are extracellular vesicles that carry proteins, lipids, and nucleic acids capable of modulating inflammation and promoting cellular regeneration. When applied topically to ocular tissues, they facilitate wound healing, reduce inflammation, and support tissue remodeling through paracrine signaling mechanisms. This approach leverages the natural regenerative properties of exosome-mediated cell-to-cell communication.","oneSentence":"Lyophilized exosomes delivered topically to the eye promote tissue repair and regeneration through delivery of bioactive molecules and stimulation of endogenous healing pathways.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:13:12.538Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Ocular surface disease and corneal wound healing"}]},"trialDetails":[{"nctId":"NCT07373054","phase":"NA","title":"Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Androgenic Alopecia","status":"RECRUITING","sponsor":"Fujian Medical University Union Hospital","startDate":"2025-11-06","conditions":"Androgenic Alopecia","enrollment":18},{"nctId":"NCT07372001","phase":"PHASE4","title":"Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device","status":"COMPLETED","sponsor":"Instituto de Oftalmología Fundación Conde de Valenciana","startDate":"2024-07-01","conditions":"Skin Aging","enrollment":30},{"nctId":"NCT06319287","phase":"PHASE2","title":"Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU)","status":"COMPLETED","sponsor":"Rion Inc.","startDate":"2024-02-27","conditions":"Diabetic Foot Ulcer","enrollment":59}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Exosomes"],"phase":"marketed","status":"active","brandName":"Topical lyophilized exosomes application","genericName":"Topical lyophilized exosomes application","companyName":"Instituto de Oftalmología Fundación Conde de Valenciana","companyId":"instituto-de-oftalmolog-a-fundaci-n-conde-de-valenciana","modality":"Biologic","firstApprovalDate":"","aiSummary":"Topical lyophilized exosomes have been studied as a potential treatment for skin aging, diabetic foot ulcers, and androgenic alopecia through clinical trials registered on ClinicalTrials.gov. The exact mechanism of action of topical lyophilized exosomes is currently unknown, according to ChEMBL.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}