{"id":"topical-intra-oral-ketoprofen-gel","safety":{"commonSideEffects":[{"rate":"null","effect":"Gastrointestinal upset"},{"rate":"null","effect":"Skin irritation"}]},"_chembl":{"chemblId":"CHEMBL571","moleculeType":"Small molecule","molecularWeight":"254.29"},"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that selectively inhibits COX-1 and COX-2 enzymes, which are responsible for the production of prostaglandins. By inhibiting these enzymes, ketoprofen reduces the production of prostaglandins, leading to decreased inflammation and pain. This mechanism of action is similar to other NSAIDs, but ketoprofen's topical and intra-oral formulation allows for localized delivery and potentially reduced systemic side effects.","oneSentence":"Ketoprofen works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:39:25.793Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relief of pain and inflammation in the mouth and gums"}]},"trialDetails":[{"nctId":"NCT01228552","phase":"PHASE3","title":"The Efficacy and Safety of Intra-oral Topical Ketoprofen for the Treatment of Acute Migraine","status":"UNKNOWN","sponsor":"Behar, Caren, M.D.","startDate":"2011-12","conditions":"Migraine Disorders, Migraine Headache, Migraine","enrollment":100},{"nctId":"NCT01211795","phase":"PHASE3","title":"Topical Intra-Oral Ketoprofen for Migraine Prevention","status":"COMPLETED","sponsor":"Behar, Caren, M.D.","startDate":"2009-10","conditions":"Migraine","enrollment":67}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Topical, intra-oral ketoprofen gel","genericName":"Topical, intra-oral ketoprofen gel","companyName":"Behar, Caren, M.D.","companyId":"behar-caren-m-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ketoprofen works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of prostaglandins, leading to reduced inflammation and pain. Used for Relief of pain and inflammation in the mouth and gums.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}