{"id":"topical-ibu-twice-daily","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It does this by inhibiting the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. Topical IBU is a nonsteroidal anti-inflammatory drug (NSAID) that is applied directly to the skin to provide localized relief from pain and inflammation.","oneSentence":"Topical IBU works by reducing pain and inflammation at the site of application.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:54:21.030Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relief of pain and inflammation associated with minor sprains, strains, and bruises"}]},"trialDetails":[{"nctId":"NCT01794923","phase":"PHASE3","title":"Topical Ibuprofen for Delayed Onset Mulscle Soreness","status":"COMPLETED","sponsor":"Pfizer","startDate":"2013-06-13","conditions":"Pain","enrollment":205},{"nctId":"NCT01945034","phase":"PHASE3","title":"5% Topical Ibuprofen (IBU) for Ankle Sprain","status":"COMPLETED","sponsor":"Pfizer","startDate":"2013-11","conditions":"Ankle Injuries","enrollment":304}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Topical IBU twice daily","genericName":"Topical IBU twice daily","companyName":"Pfizer","companyId":"pfizer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical IBU works by reducing pain and inflammation at the site of application. Used for Relief of pain and inflammation associated with minor sprains, strains, and bruises.","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}