{"id":"topical-fluorometholone","safety":{"commonSideEffects":[{"rate":null,"effect":"Elevated intraocular pressure"},{"rate":null,"effect":"Posterior subcapsular cataract formation"},{"rate":null,"effect":"Local irritation or stinging"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL1200600","moleculeType":"Small molecule","molecularWeight":"376.47"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Fluorometholone reduces inflammation by inhibiting the production of inflammatory mediators and suppressing immune cell activity at the ocular surface and anterior segment. It decreases vasodilation, edema, and cellular infiltration characteristic of inflammatory eye conditions. The drug is applied topically to achieve local anti-inflammatory effects with minimal systemic absorption.","oneSentence":"Fluorometholone is a topical corticosteroid that suppresses inflammatory and immune responses in the eye by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:10.840Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and allergic conditions of the palpebral and bulbar conjunctiva, lid, and anterior segment of the eye"},{"name":"Post-operative inflammation following ocular surgery"},{"name":"Steroid-responsive inflammatory conditions of the anterior segment"}]},"trialDetails":[{"nctId":"NCT07308938","phase":"PHASE2","title":"Fluorometholone Study","status":"NOT_YET_RECRUITING","sponsor":"Vishal Jhanji","startDate":"2026-03-31","conditions":"Keratitis Bacterial, Corneal Ulcer (Diagnosis)","enrollment":174},{"nctId":"NCT04839549","phase":"PHASE4","title":"Efficacy and Safety of Dextenza Compared to Topical Fluorometholone in Patients With Ocular Rosacea","status":"WITHDRAWN","sponsor":"Eye Associates of Central Texas","startDate":"2020-06-06","conditions":"Ocular Rosacea","enrollment":""},{"nctId":"NCT05587231","phase":"PHASE4","title":"Comparison of the Postoperative Use of Dextenza vs a Standard Regimen After PRK","status":"UNKNOWN","sponsor":"Navy Medical Center San Diego","startDate":"2022-10","conditions":"Steroid Ophthalmic Insert","enrollment":60},{"nctId":"NCT05331859","phase":"PHASE1","title":"Topical Insulin Versus Autologous Serum After Corneal Surgeries","status":"UNKNOWN","sponsor":"Benha University","startDate":"2022-05","conditions":"Corneal Epithelial Wound","enrollment":250},{"nctId":"NCT02030990","phase":"PHASE2, PHASE3","title":"The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements","status":"UNKNOWN","sponsor":"United States Naval Medical Center, San Diego","startDate":"2014-08","conditions":"Corneal Opacity","enrollment":300},{"nctId":"NCT05131152","phase":"NA","title":"Microvascular and Inflammatory Responses of 0.05 Cyclosporine Eye Drop (II) in Treatment of Dry Eye","status":"UNKNOWN","sponsor":"Zhongshan Ophthalmic Center, Sun Yat-sen University","startDate":"2021-12-01","conditions":"Dry Eye","enrollment":100},{"nctId":"NCT05011916","phase":"PHASE1, PHASE2","title":"The Safety and Efficacy of KDR2-2 Suspension Eye Drops in the Treatment of Corneal Neovascularization","status":"UNKNOWN","sponsor":"Zhongshan Ophthalmic Center, Sun Yat-sen University","startDate":"2021-08-10","conditions":"Corneal Neovascularization","enrollment":60},{"nctId":"NCT04376970","phase":"PHASE4","title":"Treatment of Corneal Infiltrates Secondary to Epidemic Keratoconjunctivitis","status":"COMPLETED","sponsor":"Military Hospital of Tunis","startDate":"2017-04-01","conditions":"Adenoviral Keratoconjunctivitis","enrollment":51},{"nctId":"NCT03747614","phase":"PHASE4","title":"Ocular Micro-vascular Research Base on Functional Slip Lamp Biomicroscopy","status":"UNKNOWN","sponsor":"Zhongshan Ophthalmic Center, Sun Yat-sen University","startDate":"2017-06-30","conditions":"Dry Eye Syndromes, Inflammation, Microvessels","enrollment":20},{"nctId":"NCT01097447","phase":"","title":"Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)","status":"TERMINATED","sponsor":"Cxlusa","startDate":"2009-12-01","conditions":"Keratoconus, Ectasia, Degeneration","enrollment":2619},{"nctId":"NCT02816905","phase":"PHASE4","title":"Ocular-hypertensive Response to Topical Steroids in Children After Bilateral Strabismus Surgery","status":"COMPLETED","sponsor":"Cairo University","startDate":"2015-10","conditions":"Intraocular Pressure","enrollment":40},{"nctId":"NCT02051023","phase":"PHASE3","title":"Efficacy and Safety of Fluorometholone (FML) in Dry Eye Disease (Keratoconjunctivitis Sicca)","status":"COMPLETED","sponsor":"Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - 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Used for Inflammatory and allergic conditions of the palpebral and bulbar conjunctiva, lid, and anterior segment of the eye, Post-operative inflammation following ocular surgery, Steroid-responsive inflammatory conditions of the anterior segment.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}