{"id":"topical-desonide-hydrogel-0-05","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin atrophy"},{"rate":null,"effect":"Burning or stinging at application site"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Folliculitis"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Desonide exerts its anti-inflammatory effects by activating glucocorticoid receptors in skin cells, which leads to reduced production of inflammatory mediators and cytokines. The hydrogel formulation provides enhanced penetration and sustained delivery to affected skin areas. This results in decreased erythema, pruritus, and other signs of dermatitis.","oneSentence":"Desonide is a topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:18.274Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Atopic dermatitis"},{"name":"Contact dermatitis"},{"name":"Seborrheic dermatitis"},{"name":"Other inflammatory skin conditions responsive to topical corticosteroids"}]},"trialDetails":[{"nctId":"NCT00690833","phase":"PHASE4","title":"Efficacy of Desonide (Desonatetm) Gel 0.05% in Younger and Older Subjects With Atopic Dermatitis","status":"COMPLETED","sponsor":"Wake Forest University","startDate":"2007-08","conditions":"Atopic Dermatitis","enrollment":41}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Desonide gel"],"phase":"marketed","status":"active","brandName":"topical desonide hydrogel 0.05%","genericName":"topical desonide hydrogel 0.05%","companyName":"Wake Forest University","companyId":"wake-forest-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Desonide is a topical corticosteroid that suppresses inflammatory and immune responses in the skin by binding to glucocorticoid receptors. Used for Atopic dermatitis, Contact dermatitis, Seborrheic dermatitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}