{"id":"topical-clotrimazole-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Contact dermatitis"}]},"_chembl":null,"_dailymed":{"setId":"b3b83f3f-9349-fb75-e053-2995a90acb65","title":"CLOTRIMAZOLE 1% TOPICAL ANTIFUNGAL CREAM (CLOTRIMAZOLE 1% ANTIFUNGAL CREAM) CREAM [MOHNARK PHARMACEUTICALS INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Clotrimazole is an imidazole antifungal that inhibits the fungal cytochrome P450 enzyme lanosterol 14α-demethylase, which is essential for converting lanosterol to ergosterol. Ergosterol is a critical component of the fungal cell membrane; its depletion leads to increased membrane permeability and leakage of cellular contents, ultimately causing fungal cell death. The topical formulation delivers the drug directly to affected skin surfaces with minimal systemic absorption.","oneSentence":"Clotrimazole inhibits fungal cell membrane synthesis by blocking ergosterol production, disrupting the integrity and function of the fungal cell membrane.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T06:29:17.827Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical fungal infections including tinea pedis (athlete's foot)"},{"name":"Tinea corporis (ringworm)"},{"name":"Tinea cruris (jock itch)"},{"name":"Candidiasis (yeast infections)"},{"name":"Pityriasis versicolor"}]},"trialDetails":[{"nctId":"NCT07441005","phase":"EARLY_PHASE1","title":"Comparative Efficacy of Topical Oxiconazole Cream (1%) Versus Topical Clotrimazole Cream (1%) in the Treatment of Tinea CrurisAbstract","status":"COMPLETED","sponsor":"Hayat Abad Medical Complex, Peshawar","startDate":"2025-05-15","conditions":"Tinea Cruris","enrollment":386},{"nctId":"NCT03437005","phase":"PHASE1","title":"Alternation in the Human Microbiome With Commonly Used Topical Medications","status":"RECRUITING","sponsor":"University of California, Davis","startDate":"2013-01-28","conditions":"Healthy","enrollment":24},{"nctId":"NCT07311759","phase":"PHASE3","title":"Safety and Efficacy of Intralesional 0.5% Triamcinolone Acetonide in 0.2% Fluconazole Solution vs 0.1% Topical Mometasone Furoate With 2% Miconazole Nitrate Cream in the Treatment of Chronic Paronychia: An Intraindividual Randomized Controlled Trial.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Cairo University","startDate":"2024-08-17","conditions":"Chronic Paronychia","enrollment":21},{"nctId":"NCT06869681","phase":"PHASE4","title":"Efficacy of Tropical Sertaconazole Nitrate 2% Vs Clotrimazole 1% for Tinea Pedis","status":"NOT_YET_RECRUITING","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2025-03-01","conditions":"Tinea Pedis","enrollment":100},{"nctId":"NCT06339294","phase":"PHASE1","title":"Efficacy of Pyodine Soaked Gelfoam vs Single Topical Application of Clotrimazole in Otomycosis Treatment","status":"COMPLETED","sponsor":"Rawalpindi Medical College","startDate":"2023-06-16","conditions":"Otomycosis","enrollment":90},{"nctId":"NCT01244256","phase":"PHASE2, PHASE3","title":"Efficacy and Comparative of the Association Beclomethasone Clotrimzaol + Gentamicin in Patients With Acne Contaminated","status":"SUSPENDED","sponsor":"Azidus Brasil","startDate":"2007-04","conditions":"Folliculitis","enrollment":80},{"nctId":"NCT03359070","phase":"PHASE2","title":"Clinical Trial Comparing Dapaconazole Versus Miconazole in Patients With Tinea Cruris","status":"COMPLETED","sponsor":"Galeno Desenvolvimento de Pesquisas Clínicas","startDate":"2014-01-29","conditions":"Tinea Cruris","enrollment":51},{"nctId":"NCT02443311","phase":"PHASE4","title":"Clinical and Immunohistochemical Effect of Topical Pimecrolimus in Treatment of Oral Lichen Planus","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2010-09","conditions":"Oral Lichen Planus","enrollment":24},{"nctId":"NCT01661556","phase":"PHASE4","title":"Clinical Trial of Hydroquinone Versus Miconazol in Melasma","status":"UNKNOWN","sponsor":"Universidad Autonoma de San Luis Potosí","startDate":"2011-10","conditions":"Melasma","enrollment":60},{"nctId":"NCT01110330","phase":"PHASE3","title":"An Efficacy Study of a New Formulation of Ketoconazole 2% Cream in Patients With Tinea Pedis, Commonly Known as Athlete's Foot","status":"TERMINATED","sponsor":"Johnson & Johnson Pharmaceutical Research & Development, L.L.C.","startDate":"2007-07","conditions":"Tinea Pedis","enrollment":583}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":5,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Topical Clotrimazole cream","genericName":"Topical Clotrimazole cream","companyName":"Hayat Abad Medical Complex, Peshawar","companyId":"hayat-abad-medical-complex-peshawar","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Clotrimazole inhibits fungal cell membrane synthesis by blocking ergosterol production, disrupting the integrity and function of the fungal cell membrane. Used for Topical fungal infections including tinea pedis (athlete's foot), Tinea corporis (ringworm), Tinea cruris (jock itch).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}