{"id":"topical-antihistamine-and-vasoconstrictor","safety":{"commonSideEffects":[{"rate":"null","effect":"Skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"They do this by blocking histamine receptors, which are involved in allergic reactions, and causing blood vessels to constrict, which reduces blood flow to the affected area. This combination of actions helps to relieve symptoms such as itching, redness, and swelling.","oneSentence":"Topical antihistamines and vasoconstrictors work by reducing itching and swelling caused by allergic reactions, and constricting blood vessels to reduce redness and inflammation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:39:19.231Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Relief of itching and inflammation associated with allergic reactions such as hives and insect bites"}]},"trialDetails":[{"nctId":"NCT01380678","phase":"PHASE3","title":"Intralesional Bevacizumab Injection on Primary Pterygium","status":"UNKNOWN","sponsor":"Khon Kaen University","startDate":"2009-01","conditions":"Pterygium, Inflammation","enrollment":206}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":18,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Hista-oph"],"phase":"phase_3","status":"active","brandName":"Topical antihistamine and vasoconstrictor","genericName":"Topical antihistamine and vasoconstrictor","companyName":"Khon Kaen University","companyId":"khon-kaen-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical antihistamines and vasoconstrictors work by reducing itching and swelling caused by allergic reactions, and constricting blood vessels to reduce redness and inflammation. Used for Relief of itching and inflammation associated with allergic reactions such as hives and insect bites.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}