{"id":"topical-analgesic","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or redness"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Burning or stinging at application site"}]},"_chembl":null,"_dailymed":{"setId":"df21d9d6-36a9-49cf-a29c-c4a573899bd5","title":"COUGH SUPPRESSANT AND TOPICAL ANALGESIC (CAMPHOR, EUCALYPTUS OIL, MENTHOL) OINTMENT [TARGET CORPORATION]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Topical analgesics function through various mechanisms depending on their active ingredients—commonly including local anesthetics (which block nerve conduction), NSAIDs (which reduce inflammation and prostaglandin production), or counterirritants (which create a competing sensation). By applying these agents directly to the affected area, they achieve localized pain relief with minimal systemic absorption and side effects.","oneSentence":"Topical analgesics work by delivering pain-relieving agents directly to the skin and underlying tissues to reduce localized pain sensation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:41:43.662Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Localized musculoskeletal pain"},{"name":"Minor arthritis pain"},{"name":"Muscle aches and strains"}]},"trialDetails":[{"nctId":"NCT07072468","phase":"PHASE2","title":"Analgesic Efficacy and Safety of Topical VMD-3866 Gel in Management of Pain Induced by Chemotherapy (CIPN)","status":"RECRUITING","sponsor":"VM Therapeutics LLC","startDate":"2025-12-12","conditions":"Chemotherapy-induced Peripheral Neuropathy, Drug-Induced Nephropathy","enrollment":16},{"nctId":"NCT07361796","phase":"NA","title":"The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain, Postherpetic Neuralgia","enrollment":832},{"nctId":"NCT07401134","phase":"PHASE4","title":"Improving Postoperative Recovery: A Study of Multimodal Perineal Analgesia Protocol (MPAP) After Vaginal Surgery","status":"RECRUITING","sponsor":"University of Miami","startDate":"2026-02-18","conditions":"Perineal Injury, Pain Vulva, Perineum; Injury","enrollment":70},{"nctId":"NCT06356311","phase":"PHASE3","title":"A Study to Evaluate Sacituzumab Tirumotecan (MK-2870) in Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-2870-015)","status":"ACTIVE_NOT_RECRUITING","sponsor":"Merck Sharp & Dohme LLC","startDate":"2024-05-03","conditions":"Gastroesophageal Cancer","enrollment":450},{"nctId":"NCT01391962","phase":"PHASE2","title":"Sunitinib or Cediranib for Alveolar Soft Part Sarcoma","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2011-07-18","conditions":"Sarcoma, Alveolar Soft Part","enrollment":34},{"nctId":"NCT07378059","phase":"NA","title":"The Analgesic Efficacy and Safety of Loxoprofen Sodium Patch in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT07370402","phase":"NA","title":"The Analgesic Efficacy and Safety of Flurbiprofen Patch in Patients With Herpes Zoster","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2025-12-15","conditions":"Herpes Zoster, Pain","enrollment":750},{"nctId":"NCT01999153","phase":"PHASE3","title":"Evaluation of the Analgesic Effect of Ropivacaine in Topical Use at the Thin Skin Graft Donor Site","status":"COMPLETED","sponsor":"University Hospital, Rouen","startDate":"2013-12-09","conditions":"Graft Pain","enrollment":58},{"nctId":"NCT07348952","phase":"NA","title":"Different Transcutaneous Electrical Nerve Stimulation Modes in Pudendal Neuralgia Post-prostatectomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-09-01","conditions":"Transcutaneous Electrical Nerve Stimulation, Pudendal Neuralgia, Post Prostatectomy","enrollment":60},{"nctId":"NCT06933381","phase":"NA","title":"Vapocoolant Spray to Reduce Pain With Nexplanon Insertion","status":"RECRUITING","sponsor":"Queen's Medical Center","startDate":"2025-06-16","conditions":"Reducing Pain With Nexplanon Implant Insertion","enrollment":70},{"nctId":"NCT02426697","phase":"PHASE3","title":"Pain Management With Pecfent in the Prevention of Pain Induced by Position in Radiotherapy","status":"COMPLETED","sponsor":"Centre Henri Becquerel","startDate":"2015-05-22","conditions":"Bone Metastasis","enrollment":39},{"nctId":"NCT07308470","phase":"PHASE2","title":"Etodolac Nanogel as an Adjunct to Physiotherapy for Knee Osteoarthritis","status":"NOT_YET_RECRUITING","sponsor":"Pharos University in Alexandria","startDate":"2026-01-08","conditions":"Knee Osteoarthritis","enrollment":30},{"nctId":"NCT07296770","phase":"PHASE3","title":"An Artificial Intelligence Driven Approach to Optimize Patient Selection for a Transitional Pain Service","status":"NOT_YET_RECRUITING","sponsor":"University of California, San Francisco","startDate":"2026-05-01","conditions":"Postsurgical Pain Management, Postsurgical Pain, Chronic, Opioid Use After Surgery","enrollment":126},{"nctId":"NCT07288021","phase":"PHASE4","title":"Topical Anesthesia During Catheter Insertion for Cervical Ripening (TOLERANCE)","status":"RECRUITING","sponsor":"Bnai Zion Medical Center","startDate":"2024-02-05","conditions":"Labor, Induced","enrollment":200},{"nctId":"NCT07273916","phase":"PHASE2","title":"Evaluation of the Efficacy and Onset of Action of a Topical Anesthetic Marker","status":"NOT_YET_RECRUITING","sponsor":"Hexsel Dermatology Clinic","startDate":"2026-03","conditions":"Pain Management","enrollment":20},{"nctId":"NCT06202989","phase":"PHASE3","title":"Multiprofen-CC™ to Reduce Pain After Total Knee Arthroplasty","status":"RECRUITING","sponsor":"KAZM Pharmaceuticals Inc.","startDate":"2024-09-09","conditions":"Postsurgical Pain","enrollment":288},{"nctId":"NCT04669093","phase":"NA","title":"Individual Differences in Placebo Analgesic Effects","status":"NOT_YET_RECRUITING","sponsor":"Trustees of Dartmouth College","startDate":"2026-09-30","conditions":"Healthy","enrollment":60},{"nctId":"NCT07246694","phase":"NA","title":"Enhanced Recovery After Uvulopalatoplasty","status":"NOT_YET_RECRUITING","sponsor":"Zagazig University","startDate":"2025-12","conditions":"Analgesia, Recovery, Psychological","enrollment":80},{"nctId":"NCT03730584","phase":"NA","title":"Evaluation of the Efficacy of ROPIVACAINE in Children and Young Adults With Hereditary Epidermolysis Bullosa","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2017-02-27","conditions":"Epidermolysis Bullosa","enrollment":10},{"nctId":"NCT05535738","phase":"PHASE2, PHASE3","title":"Using a Contact Dermatitis Model With Biologic Medications to Study Skin Inflammation","status":"RECRUITING","sponsor":"Wei-Che Ko","startDate":"2022-11-15","conditions":"Skin Inflammation, Allergic Contact Dermatitis","enrollment":45},{"nctId":"NCT06481293","phase":"NA","title":"Tackling Dry Socket Via Laser Therapy in Smokers","status":"COMPLETED","sponsor":"Badr University","startDate":"2023-10-30","conditions":"Alveolar Osteitis","enrollment":50},{"nctId":"NCT07159334","phase":"NA","title":"\"Lignocaine vs GTN Ointment for Postoperative Pain After Hemorrhoidectomy\")","status":"RECRUITING","sponsor":"King Edward Medical University","startDate":"2025-08-02","conditions":"Hemorrhoid, Postoperative Pain","enrollment":64},{"nctId":"NCT07145645","phase":"PHASE3","title":"Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children","status":"NOT_YET_RECRUITING","sponsor":"University of Calgary","startDate":"2025-09-02","conditions":"Musculoskeletal Injury, Pediatrics, Sprain and Strain of Ankle","enrollment":60},{"nctId":"NCT07002528","phase":"NA","title":"The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children","status":"ACTIVE_NOT_RECRUITING","sponsor":"Mansoura University","startDate":"2024-05-02","conditions":"Pain","enrollment":180},{"nctId":"NCT07106333","phase":"NA","title":"Assessment of Ozone Therapy for Management of Post-Extraction Localized Alveolar Osteitis","status":"NOT_YET_RECRUITING","sponsor":"Menoufia University","startDate":"2025-08-01","conditions":"Alveolar Osteitis","enrollment":40},{"nctId":"NCT07081373","phase":"NA","title":"Study on Repeat Liposomal Bupivacaine for Post-Surgery Pain in Anal Fistula Patients.","status":"RECRUITING","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2025-07-16","conditions":"Anal Fistula","enrollment":408},{"nctId":"NCT06918340","phase":"PHASE4","title":"Evaluation of Analgesic Efficacy of Lidocaine and Diclofenac Spray in Radial Artery Blood Gas Sampling by Visual Analogue Scale and Perfusion Index","status":"ACTIVE_NOT_RECRUITING","sponsor":"Haydarpasa Numune Training and Research Hospital","startDate":"2024-11-01","conditions":"Blood Gas Analysis, Topical Analgesia","enrollment":150},{"nctId":"NCT06993337","phase":"PHASE2","title":"Effect of Topical Bromelain Versus Topical Corticosteroids in the Management of Recurrent Aphthous Stomatitis","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2025-06-15","conditions":"Recurrent Aphthous Stomatitis","enrollment":63},{"nctId":"NCT04142177","phase":"NA","title":"Sequential and Comparative Evaluation of Pain Treatment Effectiveness Response","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2022-06-13","conditions":"Chronic Low Back Pain","enrollment":2529},{"nctId":"NCT06939972","phase":"NA","title":"A Single Group Study to Evaluate the Effects of a Topical Product on Cramps Associated With the Menstrual Cycle","status":"COMPLETED","sponsor":"Rael","startDate":"2024-10-03","conditions":"Dysmenorrhea, Menstrual Cramps","enrollment":40},{"nctId":"NCT06307106","phase":"NA","title":"Various Strategies to Reduce Acute Post Hemorrhoidectomy Pain: A Comparative Study","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2024-01-14","conditions":"Acute Post Operative Pain","enrollment":150},{"nctId":"NCT06235996","phase":"NA","title":"Effects of Musical Intervention on Patient Pain and Anxiety for Office-based Procedures","status":"ACTIVE_NOT_RECRUITING","sponsor":"Lake Erie College of Osteopathic Medicine","startDate":"2023-01-01","conditions":"Chronic Pain","enrollment":100},{"nctId":"NCT06257537","phase":"PHASE2","title":"Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis","status":"RECRUITING","sponsor":"ZetrOZ, Inc.","startDate":"2024-10-01","conditions":"Osteo Arthritis Knee, Arthritis","enrollment":300},{"nctId":"NCT04781335","phase":"PHASE4","title":"\"A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation\"","status":"COMPLETED","sponsor":"The Eye Institute of West Florida","startDate":"2020-02-20","conditions":"Cataract","enrollment":25},{"nctId":"NCT06836791","phase":"NA","title":"Topical 15% Trichloroacetic Acid Versus Silver Nitrate Cauterization in the Management of Idiopathic Childhood Epistaxis: A Prospective Double-Blinded, Randomized Clinical Trial","status":"COMPLETED","sponsor":"Youssef Zaki","startDate":"2023-03-01","conditions":"Anterior Epistaxis","enrollment":170},{"nctId":"NCT06754241","phase":"NA","title":"Impact of Personalized Rehabilitation Guidance","status":"COMPLETED","sponsor":"Yan Dong","startDate":"2024-01-01","conditions":"Knee Osteoarthritis","enrollment":90},{"nctId":"NCT04593849","phase":"PHASE2","title":"Therapeutic Effects of Traditional Chinese Medicine in Topical Use on Upper Extremities Fracture","status":"COMPLETED","sponsor":"YUAN-CHIEH YEH","startDate":"2020-09-23","conditions":"Bone Fractures, Traditional Chinese Medicine, Chinese Herbal Medicine","enrollment":24},{"nctId":"NCT03528369","phase":"PHASE2","title":"A Phase 2 Clinical Trial Examining the Effects on Osteoarthritic Knee Pain of CGS-200-1, CGS-200-5 and Vehicle Control","status":"COMPLETED","sponsor":"Propella Therapeutics","startDate":"2018-05-14","conditions":"Osteoarthritis, Knee, Pain","enrollment":122},{"nctId":"NCT05021354","phase":"NA","title":"Effectiveness Of A Physiotherapy Treatment Plan In Lateral Epicondylalgia","status":"COMPLETED","sponsor":"Universidad Católica de Ávila","startDate":"2023-08-01","conditions":"Humeral Epicondylitis, Lateral","enrollment":90},{"nctId":"NCT05303805","phase":"PHASE4","title":"Topical Sevoflurane for Treatment of Chronic Leg Ulcers","status":"RECRUITING","sponsor":"Charles University, Czech Republic","startDate":"2022-05-02","conditions":"Leg Ulcer","enrollment":50},{"nctId":"NCT03169140","phase":"NA","title":"Effect of at Home Pain Management Products on Acute Low Back Pain, Disability, and Range of Motion","status":"TERMINATED","sponsor":"Sport and Spine Rehab Clinical Research Foundation","startDate":"2017-02-14","conditions":"Low Back Pain, Acute Pain","enrollment":120},{"nctId":"NCT03888807","phase":"PHASE4","title":"Biofreeze® vs. a Placebo on Knee Osteoarthritis Walking Gait Characteristics and Pain","status":"TERMINATED","sponsor":"Sport and Spine Rehab Clinical Research Foundation","startDate":"2018-03-01","conditions":"Knee Osteoarthritis","enrollment":6},{"nctId":"NCT06117904","phase":"NA","title":"Adjunctive Treatments for the Prevention of Radiotherapy-Induced Mucositis","status":"COMPLETED","sponsor":"Beni-Suef University","startDate":"2024-01-01","conditions":"Radiotherapy Side Effect, Mucositis","enrollment":60},{"nctId":"NCT06420388","phase":"NA","title":"2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy","status":"RECRUITING","sponsor":"E-DA Hospital","startDate":"2023-05-01","conditions":"Surgery, Pain, Postoperative","enrollment":400},{"nctId":"NCT06393777","phase":"NA","title":"Effectiveness of Pre-administered Natural Sweet-tasting Solution (Honey) for Decreasing Pain of Needle Insertion","status":"NOT_YET_RECRUITING","sponsor":"Cairo University","startDate":"2024-09","conditions":"Analgesia","enrollment":14},{"nctId":"NCT06328153","phase":"NA","title":"Efficacy and Mechanism of FSN Treatment for Senile Knee Osteoarthritis","status":"NOT_YET_RECRUITING","sponsor":"Guangdong Provincial Hospital of Traditional Chinese Medicine","startDate":"2024-03-15","conditions":"Osteoarthritis, Knee","enrollment":60},{"nctId":"NCT05125796","phase":"NA","title":"Analgesic Use for Pain Relief in Scorpion Sting","status":"COMPLETED","sponsor":"Adiyaman University Research Hospital","startDate":"2020-09-01","conditions":"Scorpion Stings","enrollment":106},{"nctId":"NCT06214273","phase":"PHASE2","title":"Low Level Diode Laser Versus Topical Chamomile in Management of Chemotherapy Induced Oral Mucositis","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2024-04","conditions":"Chemotherapy Induced Oral Mucositis","enrollment":45},{"nctId":"NCT05641246","phase":"PHASE2","title":"Effect of Topical Diclofenac on Clinical Outcome in Breast Cancer Patients Treated With Capecitabine","status":"COMPLETED","sponsor":"German University in Cairo","startDate":"2022-12-08","conditions":"Hand and Foot Syndrome","enrollment":86},{"nctId":"NCT04484337","phase":"PHASE1","title":"Study to Evaluate Pharmacokinetic (PK), Safety and Tolerability of Cabotegravir (CAB) 400 Milligrams Per Milliliter (mg/mL) Formulation in Healthy Adult Participants","status":"COMPLETED","sponsor":"ViiV Healthcare","startDate":"2020-07-31","conditions":"HIV Infections","enrollment":138},{"nctId":"NCT05688202","phase":"NA","title":"Simultaneous Versus Sequential Fractional CO2 Laser and Subcision Combination for Post-acne Atrophic Scars: A Split-face Comparative Study.","status":"COMPLETED","sponsor":"Ho Chi Minh City Hospital of Dermato-Venereology","startDate":"2022-10-24","conditions":"Atrophic Acne Scar","enrollment":34},{"nctId":"NCT05800834","phase":"PHASE2","title":"Benefits of Morphine Gel for Pain Reduction in Patients With Cancer Wounds","status":"UNKNOWN","sponsor":"Instituto Nacional de Cancer, Brazil","startDate":"2023-09-12","conditions":"Wounds and Injuries, Cancer Pain, Cancer, Breast","enrollment":106},{"nctId":"NCT05928520","phase":"PHASE3","title":"Pain Management in Pediatric Adenotonsillectomy","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2023-08-01","conditions":"Pain Management","enrollment":80},{"nctId":"NCT04766996","phase":"PHASE4","title":"PROUD Study - Preventing Opioid Use Disorders","status":"TERMINATED","sponsor":"Emory University","startDate":"2021-05-17","conditions":"Anesthesia, Opioid Use","enrollment":57},{"nctId":"NCT05857033","phase":"NA","title":"Cold Vibratory Stimuli on Pain Perception Governing Infiltration Anesthesia in in Children","status":"UNKNOWN","sponsor":"Alexandria University","startDate":"2023-01-05","conditions":"Anesthesia, Local","enrollment":48},{"nctId":"NCT04710277","phase":"NA","title":"Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2021-04-19","conditions":"Postoperative Pain, Narcotic Use, Cryotherapy Effect","enrollment":54},{"nctId":"NCT05831761","phase":"NA","title":"Effectivness of Tramadol or Topic Lidocaine on Postoperative Analgesia in Laparoscopic Colorectal Resection.","status":"COMPLETED","sponsor":"University Medical Centre Ljubljana","startDate":"2009-09-01","conditions":"Postoperative Pain","enrollment":83},{"nctId":"NCT04337814","phase":"NA","title":"The Effect of Combined Oral and Topical Analgesics to Reduce Pain Perception During Electrodiagnostic Testing","status":"COMPLETED","sponsor":"Aga Khan University Hospital, Pakistan","startDate":"2019-12-30","conditions":"Pain Perception","enrollment":113},{"nctId":"NCT05214495","phase":"PHASE2, PHASE3","title":"Omega-3 Hydrogel and Prevention of Oral Mucositis","status":"COMPLETED","sponsor":"Basma Morsy","startDate":"2022-02-09","conditions":"Mucositis Oral","enrollment":36},{"nctId":"NCT05690100","phase":"NA","title":"Evaluation of the Use of Ozone Gel Versus Hyaluronic Acid Gel on Palatal Wound Healing .","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-01","conditions":"Palate; Wound","enrollment":56},{"nctId":"NCT05415423","phase":"NA","title":"Developing an Objective Measure of Experienced Pain","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2022-06-06","conditions":"Pain, Acute","enrollment":330},{"nctId":"NCT05500677","phase":"PHASE4","title":"Lidocaine Spray for Pain Control in Rib Fractures","status":"COMPLETED","sponsor":"Ankara City Hospital Bilkent","startDate":"2021-06-01","conditions":"Rib Fractures, Analgesia","enrollment":48},{"nctId":"NCT05458154","phase":"NA","title":"Evaluation and Re-evaluation of Post-mastectomy Pain Syndrome by Breast Cancer EDGE Task Force Outcomes","status":"COMPLETED","sponsor":"General Committee of Teaching Hospitals and Institutes, Egypt","startDate":"2021-03-03","conditions":"Post-mastectomy Pain Syndrome","enrollment":10},{"nctId":"NCT05054023","phase":"PHASE2, PHASE3","title":"Topical Piroxicam vs Soulagel in the Treatment of Acute Extremity Pain After Emergency Department Discharge","status":"COMPLETED","sponsor":"University of Monastir","startDate":"2021-10-21","conditions":"Acute Pain","enrollment":1525},{"nctId":"NCT05411913","phase":"PHASE3","title":"Topical CBD for Musculoskeletal Pain","status":"UNKNOWN","sponsor":"Apothyx, Co.","startDate":"2022-07-01","conditions":"Pain","enrollment":100},{"nctId":"NCT05208801","phase":"NA","title":"Analgesic Effect of Intrathecal Morphine Combined With Low Dose Local Anesthetics on Postoperative Analgesia After Liver Resection","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2018-11-19","conditions":"Patients Receiving Hepatectomy Under General Anesthesia","enrollment":90},{"nctId":"NCT05106400","phase":"PHASE1","title":"Clinical Adhesion Study Between ZTlido 1.8% and Three Over-the-counter External Analgesic Lidocaine-containing Patches","status":"COMPLETED","sponsor":"Scilex Pharmaceuticals, Inc.","startDate":"2021-07-01","conditions":"Healthy","enrollment":24},{"nctId":"NCT04373421","phase":"PHASE4","title":"Effect of St. John's Wort and Olive Oils on the Postoperative Complications","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2018-08-15","conditions":"Impacted Third Molar Tooth","enrollment":90},{"nctId":"NCT04995354","phase":"PHASE2, PHASE3","title":"Efficacy of EGF-loaded Self Healing Gel in Treatment of Oral Mucositis","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2022-06-01","conditions":"Oral Mucositis","enrollment":90},{"nctId":"NCT04919421","phase":"NA","title":"Comparison Between the Analgesic Effectiveness of Virtual Reality and Topical Anesthesia: A Clinical Study","status":"COMPLETED","sponsor":"Riyadh Elm University","startDate":"2019-11-10","conditions":"Pain","enrollment":20},{"nctId":"NCT04033562","phase":"PHASE4","title":"The Analgesic Efficacy of Continuous Sub-fascial Bupivacaine Infusion and Lidocaine Patches in Post-cesarean Patients With Opiate Use Disorder: A Comparative Efficacy Analysis","status":"TERMINATED","sponsor":"WellSpan Health","startDate":"2020-01-15","conditions":"Opioid-use Disorder, Opioid Use, Opioid Dependence","enrollment":2},{"nctId":"NCT02666846","phase":"PHASE1","title":"Assess the Efficacy and Safety in Volunteers of DCF100, TIB200 and SPR300 vs. Placebo and Control(s) in a UV Pain Model","status":"COMPLETED","sponsor":"Futura Medical Developments Ltd.","startDate":"2015-03","conditions":"Pain","enrollment":60},{"nctId":"NCT04677985","phase":"NA","title":"Analgesic Induces Similar Upper and Lower Body Pain Pressure Threshold Increases","status":"COMPLETED","sponsor":"Memorial University of Newfoundland","startDate":"2019-05-01","conditions":"Pain, Acute, Muscle Soreness, Tendon Injuries","enrollment":16},{"nctId":"NCT01066026","phase":"PHASE2","title":"Safety and Efficacy of a Metallic Cannula Versus A Standard Needle for Soft Tissue Augmentation of the Nasolabial Folds","status":"COMPLETED","sponsor":"Hexsel Dermatology Clinic","startDate":"2009-07","conditions":"Wrinkles","enrollment":25},{"nctId":"NCT04213924","phase":"NA","title":"Ultrasound-Guided Erector Spinae Plan Block in Patients Undergoing ESWL","status":"UNKNOWN","sponsor":"Ataturk University","startDate":"2020-06-01","conditions":"Urinary System Stones, Pain","enrollment":60},{"nctId":"NCT03516240","phase":"NA","title":"The Effect of Fatigue and Biofreeze® on the Biomechanics of Running","status":"COMPLETED","sponsor":"Brock University","startDate":"2018-06-01","conditions":"Fatigue","enrollment":20},{"nctId":"NCT04317183","phase":"PHASE2","title":"Topical Chamomile in Preventing Chemotherapy-induced Oral Mucositis","status":"UNKNOWN","sponsor":"Hams Hamed Abdelrahman","startDate":"2019-05-15","conditions":"Oral Mucositis Due to Chemotherapy","enrollment":45},{"nctId":"NCT04308161","phase":"PHASE2","title":"Vitamin D Oral Gel for Prevention of Radiation Induced Oral Mucositis","status":"UNKNOWN","sponsor":"Hams Hamed Abdelrahman","startDate":"2019-11-02","conditions":"Oral Mucositis Due to Radiation","enrollment":45},{"nctId":"NCT04270968","phase":"NA","title":"Shock Wave Therapy On Cervical Pain Following Neck Dissection Surgery","status":"COMPLETED","sponsor":"Qassim University","startDate":"2018-11-03","conditions":"Pain, Cervical Pain","enrollment":46},{"nctId":"NCT03923062","phase":"PHASE4","title":"Different Dermatological Approaches the Treatment of Melasma","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2020-02-01","conditions":"Melasma","enrollment":40},{"nctId":"NCT03383328","phase":"PHASE4","title":"Study for Optimizing Anti-inflammatory Prophylaxis","status":"COMPLETED","sponsor":"Line Kessel","startDate":"2018-02-01","conditions":"Postoperative Cystoid Macular Edema, Irvine-Gass Syndrome","enrollment":470},{"nctId":"NCT03157349","phase":"NA","title":"Effect of Biofreeze® Versus Placebo on Acute Neck Pain, Disability, and Range of Motion","status":"COMPLETED","sponsor":"Sport and Spine Rehab Clinical Research Foundation","startDate":"2017-03-01","conditions":"Acute Pain, Neck Pain","enrollment":59},{"nctId":"NCT01155986","phase":"PHASE2","title":"Lidocaine 5% Medicated Plaster in Chronic Neuropathic Postoperative Pain","status":"TERMINATED","sponsor":"Grünenthal GmbH","startDate":"2010-08","conditions":"Pain, Chronic Pain, Neuropathic Pain","enrollment":74},{"nctId":"NCT00414349","phase":"PHASE3","title":"Efficacy and Safety of Topical Versus Systemic Treatment in Postherpetic Neuralgia and Diabetic Polyneuropathic Pain","status":"COMPLETED","sponsor":"Grünenthal GmbH","startDate":"2006-12","conditions":"Neuropathic Pain","enrollment":431},{"nctId":"NCT03435367","phase":"NA","title":"Immersive Virtual Reality to Reduce Procedural Pain During IV Insertion in Children in the Emergency Department","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2018-02-01","conditions":"IV Insertion in the Emergency Department","enrollment":58},{"nctId":"NCT03833570","phase":"PHASE2","title":"Melatonin for Prevention of Radiation Induced Oral Mucositis","status":"COMPLETED","sponsor":"Hams Hamed Abdelrahman","startDate":"2018-01-12","conditions":"Oral Mucositis (Ulcerative) Due to Radiation","enrollment":40},{"nctId":"NCT01549002","phase":"PHASE3","title":"Efficacy of Intranasal Fentanyl at Reducing Pain During Abscess Incision and Drainage (I&D) in Children","status":"COMPLETED","sponsor":"Columbia University","startDate":"2012-01","conditions":"Abscess, Pain","enrollment":20},{"nctId":"NCT03146689","phase":"NA","title":"Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?","status":"COMPLETED","sponsor":"University of Nottingham","startDate":"2017-08-04","conditions":"Osteoarthritis, Knee","enrollment":22},{"nctId":"NCT03888820","phase":"PHASE4","title":"Biofreeze® vs. a Placebo on Chronic Low Back Pain Walking Gait Characteristics and Pain","status":"ACTIVE_NOT_RECRUITING","sponsor":"Sport and Spine Rehab Clinical Research Foundation","startDate":"2018-03-01","conditions":"Chronic Low Back Pain","enrollment":20},{"nctId":"NCT02974023","phase":"","title":"Efficacy of \"Pain Gear\" in Patients With Chronic Musculoskeletal Pain","status":"WITHDRAWN","sponsor":"PharmEvo Pvt Ltd","startDate":"2017-06-30","conditions":"Chronic Musculoskeletal Disease","enrollment":""},{"nctId":"NCT01653327","phase":"PHASE2","title":"Analgesic Effects of Topical Ketamine Mouthwash in Patients Receiving Chemoradiation or Radiotherapy for Head & Neck Cancer","status":"COMPLETED","sponsor":"Dartmouth-Hitchcock Medical Center","startDate":"2010-06","conditions":"Mucositis, Head and Neck Cancer","enrollment":11},{"nctId":"NCT01542827","phase":"NA","title":"Acute Effect of Topical Menthol on Neck Pain","status":"TERMINATED","sponsor":"National Research Centre for the Working Environment, Denmark","startDate":"2016-01","conditions":"Musculoskeletal Disorders","enrollment":20},{"nctId":"NCT02322164","phase":"","title":"Psychophysical Correlates of Pain Reduction by Topical Analgesic Compounds","status":"COMPLETED","sponsor":"National Center for Complementary and Integrative Health (NCCIH)","startDate":"2014-12-19","conditions":"Healthy Volunteers","enrollment":40},{"nctId":"NCT03130153","phase":"EARLY_PHASE1","title":"Topical Analgesic Versus Saline Mouth Rinses in Post Extraction Healing","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2016-01-01","conditions":"Tooth Extraction Site Healing","enrollment":60},{"nctId":"NCT02674191","phase":"NA","title":"Posterior Segment Intrusion Using Miniplates","status":"UNKNOWN","sponsor":"Manal El Namrawy","startDate":"2016-05","conditions":"Orthodontic Anchorage Procedures","enrollment":24},{"nctId":"NCT02403687","phase":"","title":"Prospective Analgesic Compound Efficacy (PACE) Study","status":"COMPLETED","sponsor":"Express Specialty Pharmacy","startDate":"2015-06","conditions":"Arthritis, Tendonitis, Gout","enrollment":300},{"nctId":"NCT02973581","phase":"NA","title":"SPI-directed Analgesia for Vitreoretinal Surgeries","status":"COMPLETED","sponsor":"Medical University of Silesia","startDate":"2016-02","conditions":"Vitreoretinal Surgeries, Postoperative Nausea and Vomiting, Postoperative Pain","enrollment":176},{"nctId":"NCT00589979","phase":"PHASE2","title":"Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee","status":"COMPLETED","sponsor":"Endo Pharmaceuticals","startDate":"2007-03","conditions":"Osteoarthritis of the Knee","enrollment":169},{"nctId":"NCT02400320","phase":"PHASE4","title":"Local Skin Safety Study of a Topical Pain Relief Spray Containing a Combination of Diclofenac, Methyl Salicylate, and Menthol","status":"WITHDRAWN","sponsor":"GlaxoSmithKline","startDate":"2016-03-01","conditions":"Skin Irritation","enrollment":""},{"nctId":"NCT02990364","phase":"PHASE3","title":"Combination Analgesia for Neonatal Circumcision","status":"COMPLETED","sponsor":"American University of Beirut Medical Center","startDate":"2015-12","conditions":"Analgesia","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":219,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Topical analgesic","genericName":"Topical analgesic","companyName":"Grünenthal GmbH","companyId":"gr-nenthal-gmbh","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical analgesics work by delivering pain-relieving agents directly to the skin and underlying tissues to reduce localized pain sensation. Used for Localized musculoskeletal pain, Minor arthritis pain, Muscle aches and strains.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}