{"id":"topical-amphimatrix","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Skin irritation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The exact mechanism of action is not well-documented, but it is believed to work by slowly releasing active ingredients into the skin, providing prolonged therapeutic effects. This can be beneficial for conditions that require consistent treatment over an extended period.","oneSentence":"Topical AmphiMatrix is a topical matrix formulation that combines multiple active ingredients to provide sustained release of therapeutic agents.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:54:20.179Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of psoriasis"}]},"trialDetails":[{"nctId":"NCT00577304","phase":"PHASE3","title":"A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud's Phenomenon","status":"UNKNOWN","sponsor":"MediQuest Therapeutics","startDate":"2007-12","conditions":"Raynaud's Disease, Raynaud's Disease Secondary to Scleroderma, Raynaud's Disease Secondary to Other Autoimmune Disease","enrollment":200},{"nctId":"NCT00666354","phase":"PHASE2","title":"Dose Response and Safety Study of Topical Methotrexate for the Treatment of Fingernail Psoriasis","status":"UNKNOWN","sponsor":"MediQuest Therapeutics","startDate":"2007-10","conditions":"Fingernail Psoriasis","enrollment":83},{"nctId":"NCT00419419","phase":"PHASE3","title":"Phase III Study of a Topical Gel Formulation for Treatment and Prevention of Raynaud's Phenomenon","status":"COMPLETED","sponsor":"MediQuest Therapeutics","startDate":"2006-12","conditions":"Raynaud's Disease, Scleroderma, Autoimmune Diseases","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Topical AmphiMatrix","genericName":"Topical AmphiMatrix","companyName":"MediQuest Therapeutics","companyId":"mediquest-therapeutics","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Topical AmphiMatrix is a topical matrix formulation that combines multiple active ingredients to provide sustained release of therapeutic agents. Used for Treatment of psoriasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}