{"id":"tookad-soluble","safety":{"commonSideEffects":[{"rate":null,"effect":"Urinary symptoms (dysuria, frequency, urgency)"},{"rate":null,"effect":"Perineal pain"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Hematuria"},{"rate":null,"effect":"Phototoxicity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"TOOKAD (palladium bacteriopheophorbide) is a photosensitizer that, when activated by near-infrared light, produces singlet oxygen and reactive oxygen species that selectively damage tumor blood vessels, leading to tumor necrosis. The drug is administered intravenously and then activated by transurethral light delivery, making it particularly suited for localized tumors accessible to light delivery.","oneSentence":"TOOKAD Soluble is a vascular-targeting photodynamic therapy agent that generates reactive oxygen species upon light activation to destroy tumor vasculature.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:39:23.571Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Localized prostate cancer (intermediate and high-risk disease)"}]},"trialDetails":[{"nctId":"NCT03315754","phase":"PHASE2","title":"Study of the Efficacy, Safety and Quality of Life After TOOKAD® Soluble (VTP) for Intermediate Risk Prostate Cancer.","status":"ACTIVE_NOT_RECRUITING","sponsor":"Steba Biotech S.A.","startDate":"2017-10-02","conditions":"Localized Prostate Cancer","enrollment":50},{"nctId":"NCT00946881","phase":"PHASE1, PHASE2","title":"Safety and Tolerability Study Using WST11 In Patients With Localized Prostate Cancer","status":"COMPLETED","sponsor":"Steba Biotech S.A.","startDate":"2009-07","conditions":"Prostate Cancer","enrollment":30},{"nctId":"NCT04017325","phase":"","title":"European Randomised Study of TOOKAD® Soluble for Prostate Cancer vs Active Surveillance. Post Study Follow-up","status":"COMPLETED","sponsor":"Steba Biotech S.A.","startDate":"2016-03-17","conditions":"Cancer of the Prostate","enrollment":374},{"nctId":"NCT01310894","phase":"PHASE3","title":"Efficacy and Safety Study of TOOKAD® Soluble for Localised Prostate Cancer Compared to Active Surveillance.","status":"COMPLETED","sponsor":"Steba Biotech S.A.","startDate":"2011-02","conditions":"Prostate Cancer","enrollment":413},{"nctId":"NCT00707356","phase":"PHASE2","title":"Study of WST11 in Patients With Localized Prostate Cancer","status":"COMPLETED","sponsor":"Steba Biotech S.A.","startDate":"2008-09","conditions":"Prostate Cancer","enrollment":42},{"nctId":"NCT01875393","phase":"PHASE3","title":"Efficacy,Safety and Quality of Life After TOOKAD® Soluble VTP for Localized Prostate Cancer","status":"COMPLETED","sponsor":"Steba Biotech S.A.","startDate":"2013-05","conditions":"Prostate Cancer","enrollment":81},{"nctId":"NCT00975429","phase":"PHASE2","title":"Study Using WST11 in Patients With Localized Prostate Cancer","status":"COMPLETED","sponsor":"Steba Biotech S.A.","startDate":"2009-09","conditions":"Prostate Cancer","enrollment":86}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["WST11"],"phase":"phase_3","status":"active","brandName":"TOOKAD® Soluble","genericName":"TOOKAD® Soluble","companyName":"Steba Biotech S.A.","companyId":"steba-biotech-s-a","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TOOKAD Soluble is a vascular-targeting photodynamic therapy agent that generates reactive oxygen species upon light activation to destroy tumor vasculature. Used for Localized prostate cancer (intermediate and high-risk disease).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}