{"id":"tonzonium","rwe":[],"tags":[{"label":"tonzonium","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Insulin-degrading enzyme","category":"target"},{"label":"IDE","category":"gene"},{"label":"Auricular (Otic)","category":"route"},{"label":"Suspension","category":"form"},{"label":"Active","category":"status"},{"label":"Mastoidectomy Cavity Infections","category":"indication"},{"label":"Otitis externa","category":"indication"},{"label":"Par Sterile Products","category":"company"},{"label":"Approved 1960s","category":"decade"}],"phase":"marketed","safety":{"commonSideEffects":[],"contraindications":["Bullous myringitis","Fungal ear infection","Herpes simplex","Herpes zoster auricularis","Perforation of tympanic membrane","Tuberculosis of ear","Viral ear infection"],"specialPopulations":{"Pregnancy":"There are no adequate and well controlled studies of Cortisporin(R)-TC Otic Suspension in pregnant women. It is not known whether Cortisporin(R)-TC Otic Suspension can cause fetal harm when administered to pregnant woman. Colistimethate sodium, the methanesulfonate salt of colistin, was not teratogenic in rats or rabbits given intramuscular doses up to 20 mg/kg (equivalent to 9.3 mg/kg of colisitin base, approximately 30 times (rats) or 55 ti","Geriatric use":"No overall differences in safety or effectiveness have been observed between elderly and younger patients.","Paediatric use":"The safety and effectiveness of Cortisporin(R)-TC Otic Suspension in infants below one year of age have not been established. The efficacy of Cortisporin(R)-TC Otic Suspension in pediatric patients one year or older in the treatment of superficial bacterial infections of the external auditory canal and for the treatment of infections of mastoidectomy and fenestration cavities has been demonstrated in controlled clinical trial."}},"trials":[],"aliases":[],"company":"Par Sterile Products","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=tonzonium","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T00:18:36.124250+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T00:18:41.657041+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tonzonium","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T00:18:42.000247+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201322/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T00:18:43.042898+00:00"}},"allNames":"coly-mycin s","offLabel":[],"synonyms":["tonzonium","thonzonium bromide","tonzonium bromide","thonzide","thonzonium"],"timeline":[{"date":"1962-05-17","type":"positive","source":"DrugCentral","milestone":"FDA approval (Par Sterile Products)"}],"approvals":[{"date":"1962-05-17","orphan":false,"company":"PAR STERILE PRODUCTS","regulator":"FDA"}],"brandName":"Coly-Mycin 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Molecule","drugClass":"tonzonium","explanation":"","oneSentence":"","technicalDetail":"Tonzonium is a competitive inhibitor of insulin-degrading enzyme, binding to the enzyme's active site and preventing the breakdown of insulin and other proteins."},"commercial":{"launchDate":"1962","_launchSource":"DrugCentral (FDA 1962-05-17, PAR STERILE PRODUCTS)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4605","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tonzonium","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:02:33.672813","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T00:18:44.759754+00:00","fieldsConflicting":2,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"biotin","drugSlug":"biotin","fdaApproval":"1953-02-20","relationship":"same-target"},{"drugName":"cefmetazole","drugSlug":"cefmetazole","fdaApproval":"1989-12-11","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"rabeprazole","drugSlug":"rabeprazole","fdaApproval":"1999-08-19","genericCount":10,"patentStatus":"Off-patent — generic 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