{"id":"tolpropamine","rwe":[{"pmid":"39636659","year":"2024","title":"Highly Enantioselective Synthesis of 3,3-Diarylpropyl Amines and 4-Aryl Tetrahydroquinolines via Ir-Catalyzed Asymmetric Hydrogenation.","finding":"","journal":"Organic letters","studyType":"Clinical Study"},{"pmid":"2905706","year":"1988","title":"Identification and differentiation of alkylamine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry.","finding":"","journal":"Journal of chromatography","studyType":"Clinical Study"}],"tags":[{"label":"tolpropamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D04AA12","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"pragman","offLabel":[],"synonyms":["tolpropamine","pragman"],"timeline":[],"approvals":[],"brandName":"Pragman","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"tolpropamine","explanation":"Imagine your brain is like a city with many different streets and intersections. Tolpropamine helps regulate the flow of chemical messengers, called neurotransmitters, that travel along these streets to communicate with different parts of the brain. By adjusting the activity of these neurotransmitters, tolpropamine may help alleviate certain symptoms or conditions.","oneSentence":"Tolpropamine is thought to work by modulating the activity of certain neurotransmitters in the brain.","technicalDetail":"Tolpropamine is a non-selective adrenergic agonist that interacts with alpha and beta-adrenergic receptors in the central nervous system, potentially influencing various physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3618","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TOLPROPAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:57:23.496612","biosimilars":[],"competitors":[{"drugName":"mepyramine","drugSlug":"mepyramine","fdaApproval":"1973-08-07","relationship":"same-class"},{"drugName":"tripelennamine","drugSlug":"tripelennamine","fdaApproval":"1948-02-19","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"promethazine","drugSlug":"promethazine","fdaApproval":"1951-03-29","genericCount":48,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"clemastine","drugSlug":"clemastine","fdaApproval":"1977-02-25","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"pheniramine","drugSlug":"pheniramine","fdaApproval":"1994-06-08","relationship":"same-class"},{"drugName":"diphenhydramine","drugSlug":"diphenhydramine","fdaApproval":"1946-03-04","genericCount":56,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"tolpropamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"mepyramine","brandName":"mepyramine","genericName":"mepyramine","approvalYear":"1973","relationship":"same-class"},{"drugId":"tripelennamine","brandName":"tripelennamine","genericName":"tripelennamine","approvalYear":"1948","relationship":"same-class"},{"drugId":"promethazine","brandName":"promethazine","genericName":"promethazine","approvalYear":"1951","relationship":"same-class"},{"drugId":"clemastine","brandName":"clemastine","genericName":"clemastine","approvalYear":"1977","relationship":"same-class"},{"drugId":"pheniramine","brandName":"pheniramine","genericName":"pheniramine","approvalYear":"1994","relationship":"same-class"},{"drugId":"diphenhydramine","brandName":"diphenhydramine","genericName":"diphenhydramine","approvalYear":"1946","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"TBZ8909KFS","CHEBI":"CHEBI:135035","INN_ID":"1346","UMLSCUI":"C0076805","ChEMBL_ID":"CHEMBL2107261","KEGG_DRUG":"D07196","DRUGBANK_ID":"DB13305","PUBCHEM_CID":"72141","MESH_SUPPLEMENTAL_RECORD_UI":"C005547"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":2,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"D04AA12","allCodes":["D04AA12"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Dec 20","pmid":"39636659","title":"Highly Enantioselective Synthesis of 3,3-Diarylpropyl Amines and 4-Aryl Tetrahydroquinolines via Ir-Catalyzed Asymmetric Hydrogenation.","journal":"Organic letters"},{"date":"1988 Aug 19","pmid":"2905706","title":"Identification and differentiation of alkylamine antihistamines and their metabolites in urine by computerized gas chromatography-mass spectrometry.","journal":"Journal of chromatography"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tolpropamine is a small molecule. It has synonyms including TOLPROPAMINA and TOLPROPAMINE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}