{"id":"tolonidine","rwe":[{"pmid":"3797809","year":"1986","title":"Behavioral and electrocortical effects of tolonidine in rats.","finding":"","journal":"Research communications in chemical pathology and pharmacology","studyType":"Clinical Study"},{"pmid":"1243090","year":"1975","title":"Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"1243037","year":"1975","title":"Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"3186","year":"1975","title":"Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"}],"tags":[{"label":"tolonidine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"C02AC04","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["tolonidine mononitrate","tolonidine monohydrochloride","tolonidine nitrate","tolonidine"],"offLabel":[],"synonyms":["tolonidine mononitrate","tolonidine monohydrochloride","tolonidine nitrate","tolonidine"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"tolonidine","explanation":"Imagine your brain as a computer, and the chemicals in your brain as the software that makes it work. Tolonidine is like a new piece of software that is designed to interact with the existing software in your brain to produce a specific effect. However, the exact details of how it works are not yet understood.","oneSentence":"Tolonidine is thought to work by interacting with the body's central nervous system to produce a specific effect.","technicalDetail":"Tolonidine is a centrally acting alpha-2 adrenergic agonist, but the precise mechanism of action and its relationship to the alpha-2 adrenergic receptor are not well characterized."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2700","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TOLONIDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:57:19.823046","biosimilars":[],"competitors":[{"drugName":"clonidine","drugSlug":"clonidine","fdaApproval":"1974-09-03","patentExpiry":"Sep 8, 2031","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"guanfacine","drugSlug":"guanfacine","fdaApproval":"1986-10-27","genericCount":21,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"tolonidine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"clonidine","brandName":"clonidine","genericName":"clonidine","approvalYear":"1974","relationship":"same-class"},{"drugId":"guanfacine","brandName":"guanfacine","genericName":"guanfacine","approvalYear":"1986","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005731","UNII":"I4O795Q03O","CHEBI":"CHEBI:134879","INN_ID":"3265","UMLSCUI":"C0076803","ChEMBL_ID":"CHEMBL304253","KEGG_DRUG":"D07168","DRUGBANK_ID":"DB13429","PUBCHEM_CID":"72138","SECONDARY_CAS_RN":"57524-15-9","MESH_SUPPLEMENTAL_RECORD_UI":"C011558"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":4,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"C02AC04","allCodes":["C02AC04"]},"biosimilarFilings":[],"recentPublications":[{"date":"1986 Dec","pmid":"3797809","title":"Behavioral and electrocortical effects of tolonidine in rats.","journal":"Research communications in chemical pathology and pharmacology"},{"date":"1975 Nov","pmid":"1243090","title":"Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. II. Action on cardiac contraction, circulatory parameters, autonomic receptors and diuresis.","journal":"Arzneimittel-Forschung"},{"date":"1975 Oct","pmid":"1243037","title":"Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (Tolonidine), a new antihypertensive agent. I. Action on blood pressure and heart rate.","journal":"Arzneimittel-Forschung"},{"date":"1975","pmid":"3186","title":"Pharmacological properties of 2-(2-chloro-p-toluidino)-2-imidazoline-nitrate (tolonidine), a new antihypertensive agent. III. Action on the secretions of the digestive tract and on the central nervous system, acute toxicity.","journal":"Arzneimittel-Forschung"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"TOLONIDINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tolonidine is a small molecule medication. It is also known by other names, including ST 375, ST-375, Tolonidina, and Tolonidine.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}