{"id":"todralazine","rwe":[{"pmid":"25517940","year":"2015","title":"Todralazine protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion.","finding":"","journal":"Zebrafish","studyType":"Clinical Study"},{"pmid":"17161489","year":"2007","title":"Todralazine hepatotoxicity: a sting in the histone tail.","finding":"","journal":"Journal of hepatology","studyType":"Clinical Study"},{"pmid":"17156885","year":"2007","title":"A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives.","finding":"","journal":"Journal of hepatology","studyType":"Clinical Study"},{"pmid":"11753436","year":"2001","title":"DNA repair of hydrogen peroxide-induced damage in human lymphocytes in the presence of four antimutagens. A study with alkaline single cell gel electrophoresis (comet assay).","finding":"","journal":"Cellular & molecular biology letters","studyType":"Clinical Study"},{"pmid":"11598640","year":"2001","title":"Impact of four antimutagens on apoptosis in genotoxically damaged lymphocytes in vitro.","finding":"","journal":"Cellular & molecular biology letters","studyType":"Clinical Study"}],"tags":[{"label":"todralazine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antihypertensive Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"carboethoxyphthalazinohydrazine","offLabel":[],"synonyms":["todralazine","carboethoxyphthalazinohydrazine","todralazine hydrochloride","todralazine HCl"],"timeline":[],"approvals":[],"brandName":"Carboethoxyphthalazinohydrazine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"todralazine","explanation":"Imagine your body's response to certain stimuli is like a volume control on a radio. Todralazine is thought to adjust this volume control, making it easier for your body to respond to certain signals. This can help with various bodily functions, but the specifics of how it works are still being studied.","oneSentence":"Todralazine is thought to work by modulating the body's response to certain stimuli, although the exact details of its mechanism are unclear.","technicalDetail":"Todralazine's mechanism of action is believed to involve the modulation of voltage-gated calcium channels, although the exact molecular details are not well-documented."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2691","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TODRALAZINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:01:35.594626","biosimilars":[],"competitors":[],"genericName":"todralazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"WEN3K83YKD","CHEBI":"CHEBI:94706","INN_ID":"3122","UMLSCUI":"C0040354","ChEMBL_ID":"CHEMBL1079787","KEGG_DRUG":"D01951","PUBCHEM_CID":"5501","MESH_DESCRIPTOR_UI":"D014032"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2015 Feb","pmid":"25517940","title":"Todralazine protects zebrafish from lethal effects of ionizing radiation: role of hematopoietic cell expansion.","journal":"Zebrafish"},{"date":"2007 Feb","pmid":"17161489","title":"Todralazine hepatotoxicity: a sting in the histone tail.","journal":"Journal of hepatology"},{"date":"2007 Feb","pmid":"17156885","title":"A novel mechanism for drug-induced liver failure: inhibition of histone acetylation by hydralazine derivatives.","journal":"Journal of hepatology"},{"date":"2001","pmid":"11753436","title":"DNA repair of hydrogen peroxide-induced damage in human lymphocytes in the presence of four antimutagens. 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