{"id":"tocopherol-succinate","rwe":[{"pmid":"41774233","year":"2026","title":"Protective effect of alpha-tocopherol succinate on Al₂O₃-NPs induced damage in NMRI mice Sertoli cells: the role of inhibin B and Connexin 43.","finding":"","journal":"Molecular biology reports","studyType":"Clinical Study"},{"pmid":"40967533","year":"2025","title":"The combination of a small molecular prodrug and hyaluronic acid-tocopherol assembly as a nano-agent for the synergistic therapy of cervical cancer.","finding":"","journal":"International journal of biological macromolecules","studyType":"Clinical Study"},{"pmid":"40882575","year":"2025","title":"Redox-responsive self-targeting carrier-free nanotherapeutic agent with ROS storm for enhancing tumor oxidative stress.","finding":"","journal":"Colloids and surfaces. B, Biointerfaces","studyType":"Clinical Study"},{"pmid":"40823696","year":"2025","title":"Redefining platinum(IV) chemotherapy: α-tocopherol succinate functionalization and nanoparticle encapsulation to improve cisplatin- and oxaliplatin-based therapies.","finding":"","journal":"Dalton transactions (Cambridge, England : 2003)","studyType":"Clinical Study"},{"pmid":"40819791","year":"2025","title":"Impact of α-tocopherol derivatives on the structural and functional properties of model lipid nanocarriers: A biophysical modeling study.","finding":"","journal":"Chemistry and physics of lipids","studyType":"Clinical Study"}],"_fda":{"id":"30c8e7e7-7cba-c12f-e063-6394a90a41e9","set_id":"b9b71fa4-89c7-4f5b-8174-950649434ba5","openfda":{"nui":["N0000193618","M0001797","M0022797","N0000175952","N0000185508","N0000175629","N0000184306","M0000728","M0022794","N0000175951","M0022788","N0000175950"],"upc":["0306420207907"],"unii":["LU4B53JYVE","73Y7P0K73Y","PQ6CK8PD0R","6SO6U10H04","568ET80C3D","1C6V77QF41","0R0008Q3JB","LRX7AJ16DT","P6YC3EG204","935E97BOY8","X72A60C9MT","3A3U0GI71G","42Z2K6ZL8P","25X51I8RD4","68Y4CF58BV","TLM2976OFR","H6241UJ22B","X66NSO3N35","81G40H8B0T","SOI2LOH54Z"],"route":["ORAL"],"spl_id":["30c8e7e7-7cba-c12f-e063-6394a90a41e9"],"brand_name":["Strovite One Caplets"],"spl_set_id":["b9b71fa4-89c7-4f5b-8174-950649434ba5"],"package_ndc":["0642-0207-90","0642-0207-03"],"product_ndc":["0642-0207"],"generic_name":["VITAMIN A, CALCIUM PANTOTHENATE, ASCORBIC ACID, CHOLECALCIFEROL, .ALPHA.-TOCOPHEROL SUCCINATE, D-, THIAMINE, RIBOFLAVIN, NIACINAMIDE, PYRIDOXINE HYDROCHLORIDE, FOLIC ACID, BIOTIN, CYANOCOBALAMIN, SELENIUM, MAGNESIUM OXIDE, ZINC OXIDE, CUPRIC SULFATE, MANGANESE, CHROMIUM, .ALPHA.-LIPOIC ACID, AND LUTEIN"],"product_type":["HUMAN PRESCRIPTION DRUG"],"pharm_class_cs":["Ascorbic Acid [CS]","Vitamin D [CS]","Allergens [CS]","Vitamin B 12 [CS]","Vitamin A [CS]"],"pharm_class_pe":["Increased Histamine Release [PE]","Cell-mediated Immunity [PE]"],"substance_name":[".ALPHA.-TOCOPHEROL SUCCINATE, D-","ALPHA LIPOIC ACID","ASCORBIC ACID","BIOTIN","CALCIUM PANTOTHENATE","CHOLECALCIFEROL","CHROMIUM","CUPRIC SULFATE","CYANOCOBALAMIN","FOLIC ACID","LUTEIN","MAGNESIUM OXIDE","MANGANESE","NIACINAMIDE","PYRIDOXINE HYDROCHLORIDE","RIBOFLAVIN","SELENIUM","THIAMINE","VITAMIN A","ZINC OXIDE"],"pharm_class_epc":["Vitamin C [EPC]","Vitamin D [EPC]","Standardized Chemical Allergen [EPC]","Vitamin B12 [EPC]","Vitamin A [EPC]"],"manufacturer_name":["Exeltis USA, Inc."],"is_original_packager":[true]},"version":"5","description":["COMPOSITION Each caplet contains: Vitamin A (as beta carotene) 900 mcg RAE Vitamin C 300 mg Vitamin D (as cholecalciferol) 25 mcg Vitamin E (as d-alpha tocopheryl succinate) 67 mg Thiamin (as thiamine hydrochloride) 20 mg Riboflavin (vitamin B2) 5 mg Niacin (as niacinamide) 25 mg NE Vitamin B6 (as pyridoxine hydrochloride) 25 mg Folate (as folic acid) 1,670 mcg DFE Vitamin B12 (as cyanocobalamin) 50 mcg Biotin 100 mcg Pantothenic Acid (as calcium-D-pantothenate) 15 mg Magnesium (as magnesium oxide) 50 mg Zinc (as zinc oxide) 25 mg Selenium (as sodium selenate) 100 mcg Copper (as cupric sulfate) 1.5 mg Manganese (as manganese sulfate) 1.5 mg Chromium (as chromium chloride) 50 mcg Alpha Lipoic Acid 7.5 mg Lutein 5 mg Other ingredients: Microcrystalline cellulose, dicalcium phosphate, hydroxypropyl methylcellulose, croscarmellose sodium, polyethylene glycol, titanium dioxide, talc, maltodextrin, modified food starch, sucrose, polyvinyl alcohol, stearic acid, silica, magnesium stearate, corn oil, starch, vitamin E alcohol, sodium ascorbate, mannitol."],"precautions":["Drug Interactions High doses of folic acid may result in decreased serum levels of anticonvulsant drugs. Vitamin D supplementation should not be given with large amounts of calcium in those with hypercalcemia or conditions that may lead to hyper-calcemia such as hyperparathyroidism and those who form calcium-containing kidney stones. Zinc can inhibit the absorption of certain antibiotics; take at least 2 hours apart to minimize interactions. Consult appropriate references for additional specific vitamin-drug interactions. Information for Patients Patients should be counseled to disclose all medical conditions, including use of all medications, vitamins and supplements, pregnancy, and breastfeeding. Pediatric Use Not recommended for pediatric use."],"how_supplied":["HOW SUPPLIED STROVITE ® ONE is a white, oblong caplet, debossed EV0207; available in bottles of 90 caplets (0642-0207-90) and as professional samples (0642-0207-03). Storage conditions: Store at room temperature 15°-30°C (59°-86°F). Avoid excessive heat and moisture."],"pediatric_use":["Pediatric Use Not recommended for pediatric use."],"effective_time":"20250320","adverse_reactions":["ADVERSE REACTIONS Adverse reactions have been reported with specific vitamins and minerals, but generally at levels substantially higher than those in STROVITE ® ONE."],"contraindications":["CONTRAINDICATIONS STROVITE ® ONE is contraindicated in patients with hypersensitivity to any of its components. Folic Acid is contraindicated in patients with untreated and uncomplicated pernicious anemia, and in those with anaphylactic sensitivity to folic acid. Cyanocobalamin is contraindicated in patients with sensitivity to cobalt or to cyanocobalamin (Vitamin B12)."],"description_table":["<table width=\"60%\" styleCode=\"Noautorules\"><colgroup><col align=\"left\" valign=\"top\" width=\"76%\"/><col align=\"left\" valign=\"top\" width=\"3%\"/><col align=\"left\" valign=\"top\" width=\"21%\"/></colgroup><tbody><tr><td colspan=\"3\"><content styleCode=\"bold\">Each caplet contains:</content></td></tr><tr><td>Vitamin A (as beta carotene)</td><td/><td>900 mcg RAE</td></tr><tr><td>Vitamin C </td><td/><td>300 mg</td></tr><tr><td>Vitamin D (as cholecalciferol)</td><td/><td>25 mcg</td></tr><tr><td>Vitamin E (as d-alpha tocopheryl succinate)</td><td/><td>67 mg</td></tr><tr><td>Thiamin (as thiamine hydrochloride)</td><td/><td>20 mg</td></tr><tr><td>Riboflavin (vitamin B2)</td><td/><td>5 mg</td></tr><tr><td>Niacin (as niacinamide)</td><td/><td>25 mg NE</td></tr><tr><td>Vitamin B6 (as pyridoxine hydrochloride)</td><td/><td>25 mg</td></tr><tr><td>Folate (as folic acid)</td><td/><td>1,670 mcg DFE</td></tr><tr><td>Vitamin B12 (as cyanocobalamin)</td><td/><td>50 mcg</td></tr><tr><td>Biotin</td><td/><td>100 mcg</td></tr><tr><td>Pantothenic Acid (as calcium-D-pantothenate)</td><td/><td>15 mg</td></tr><tr><td>Magnesium (as magnesium oxide)</td><td/><td>50 mg</td></tr><tr><td>Zinc (as zinc oxide)</td><td/><td>25 mg</td></tr><tr><td>Selenium (as sodium selenate)</td><td/><td>100 mcg</td></tr><tr><td>Copper (as cupric sulfate)</td><td/><td>1.5 mg</td></tr><tr><td>Manganese (as manganese sulfate)</td><td/><td>1.5 mg</td></tr><tr><td>Chromium (as chromium chloride)</td><td/><td>50 mcg</td></tr><tr><td>Alpha Lipoic Acid</td><td/><td>7.5 mg</td></tr><tr><td>Lutein</td><td/><td>5 mg</td></tr></tbody></table>"],"drug_interactions":["Drug Interactions High doses of folic acid may result in decreased serum levels of anticonvulsant drugs. Vitamin D supplementation should not be given with large amounts of calcium in those with hypercalcemia or conditions that may lead to hyper-calcemia such as hyperparathyroidism and those who form calcium-containing kidney stones. Zinc can inhibit the absorption of certain antibiotics; take at least 2 hours apart to minimize interactions. Consult appropriate references for additional specific vitamin-drug interactions."],"storage_and_handling":["Storage conditions: Store at room temperature 15°-30°C (59°-86°F). Avoid excessive heat and moisture."],"indications_and_usage":["INDICATIONS AND USAGE STROVITE ® ONE is indicated to provide nutritional supplementation to support optimum vitamin and mineral levels."],"warnings_and_cautions":["WARNING/PRECAUTIONS Vitamin D supplementation should be used with caution in those with hypercalcemia or conditions that may lead to hypercalcemia such as hyperparathyroidism and those who form calcium-containing kidney stones. High doses of vitamin D can lead to elevated levels of calcium that reside in the blood and soft tissues. Bone pain, high blood pressure, formation of kidney stones, renal failure, and increased risk of heart disease can occur. Folic acid, especially in doses above 0.1 mg daily, may obscure pernicious anemia, in that hematologic remission may occur while neurological manifestations remain progressive. The use of folic acid doses above 1 mg daily may precipitate or exacerbate the neurological damage of vitamin B12 deficiency. Avoid overdosage. Keep out of the reach of children."],"information_for_patients":["Information for Patients Patients should be counseled to disclose all medical conditions, including use of all medications, vitamins and supplements, pregnancy, and breastfeeding."],"spl_unclassified_section":["0642-0207-90 STROVITE ® ONE IRON FREE MULTIVITAMIN AND MINERAL SUPPLEMENT Rx","KEEP OUT OF REACH OF CHILDREN. Rx MANUFACTURED IN THE USA Distributed by: Exeltis USA, Inc. Florham Park, NJ 07932 1-877-324-9349 www.exeltisusa.com ©2022 Exeltis USA, Inc. All rights reserved. US PATENT NO. 6,863,904 STROVITE ® ONE is a trademark of Exeltis Healthcare S.L. Rev. 10/2022 2079003-04"],"dosage_and_administration":["DOSAGE AND ADMINISTRATION One caplet daily or as directed by a physician."],"spl_product_data_elements":["Strovite One Caplets Vitamin A, Calcium Pantothenate, Ascorbic Acid, Cholecalciferol, .Alpha.-Tocopherol Succinate, D-, Thiamine, Riboflavin, Niacinamide, Pyridoxine Hydrochloride, Folic Acid, Biotin, Cyanocobalamin, Selenium, Magnesium Oxide, Zinc Oxide, Cupric Sulfate, Manganese, Chromium, .Alpha.-Lipoic Acid, and Lutein HYDROXYPROPYL METHYLCELLULOSE MALTODEXTRIN STEARIC ACID MANNITOL MANGANESE MANGANESE CROSCARMELLOSE SODIUM MICROCRYSTALLINE CELLULOSE SILICON DIOXIDE TITANIUM DIOXIDE MAGNESIUM STEARATE POLYVINYL ALCOHOL, UNSPECIFIED STARCH, CORN TALC SUCROSE POLYETHYLENE GLYCOL, UNSPECIFIED ANHYDROUS DIBASIC CALCIUM PHOSPHATE TOCOPHEROL SODIUM ASCORBATE .ALPHA.-TOCOPHEROL, DL- VITAMIN A VITAMIN A CALCIUM PANTOTHENATE PANTOTHENIC ACID CALCIUM CATION ASCORBIC ACID ASCORBIC ACID CHOLECALCIFEROL CHOLECALCIFEROL .ALPHA.-TOCOPHEROL SUCCINATE, D- .ALPHA.-TOCOPHEROL, D- THIAMINE THIAMINE ION RIBOFLAVIN RIBOFLAVIN NIACINAMIDE NIACINAMIDE PYRIDOXINE HYDROCHLORIDE PYRIDOXINE FOLIC ACID FOLIC ACID BIOTIN BIOTIN CYANOCOBALAMIN CYANOCOBALAMIN SELENIUM SELENIUM MAGNESIUM OXIDE MAGNESIUM CATION ZINC OXIDE ZINC OXIDE CUPRIC SULFATE CUPRIC CATION CHROMIUM CHROMIUM ALPHA LIPOIC ACID ALPHA LIPOIC ACID LUTEIN LUTEIN MODIFIED CORN STARCH (1-OCTENYL SUCCINIC ANHYDRIDE) CORN OIL EV0207"],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 90 Caplet Bottle Label 0642-0207-90 Strovite ® ONE IRON FREE MULTIVITAMIN AND MINERAL SUPPLEMENT GLUTEN AND LACTOSE FREE 90 Caplets Rx Strovite One Bottle Label"]},"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Oral","category":"route"},{"label":"Liquid","category":"form"},{"label":"Solution","category":"form"},{"label":"Tablet","category":"form"},{"label":"Active","category":"status"},{"label":"Antioxidants","category":"pharmacology"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Protective Agents","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"commonSideEffects":[{"effect":"Hypophosphatemia","drugRate":"","severity":"serious","_validated":false,"_confidence":0.3},{"effect":"Nausea","drugRate":"reported","severity":"unknown"},{"effect":"Vomiting","drugRate":"reported","severity":"unknown"},{"effect":"Diarrhea","drugRate":"reported","severity":"unknown"},{"effect":"Abdominal pain","drugRate":"reported","severity":"unknown"},{"effect":"Fatigue","drugRate":"reported","severity":"unknown"},{"effect":"Headache","drugRate":"reported","severity":"unknown"},{"effect":"Dizziness","drugRate":"reported","severity":"unknown"},{"effect":"Muscle weakness","drugRate":"reported","severity":"unknown"},{"effect":"Muscle cramps","drugRate":"reported","severity":"unknown"},{"effect":"Tingling","drugRate":"reported","severity":"unknown"},{"effect":"Paresthesia","drugRate":"reported","severity":"unknown"},{"effect":"Rash","drugRate":"reported","severity":"unknown"},{"effect":"Itching","drugRate":"reported","severity":"unknown"},{"effect":"Hives","drugRate":"reported","severity":"unknown"},{"effect":"Swelling","drugRate":"reported","severity":"unknown"},{"effect":"Weight loss","drugRate":"reported","severity":"unknown"},{"effect":"Weight gain","drugRate":"reported","severity":"unknown"},{"effect":"Tremors","drugRate":"reported","severity":"unknown"},{"effect":"Seizures","drugRate":"reported","severity":"unknown"},{"effect":"Confusion","drugRate":"reported","severity":"unknown"},{"effect":"Anxiety","drugRate":"reported","severity":"unknown"},{"effect":"Insomnia","drugRate":"reported","severity":"unknown"},{"effect":"Tachycardia","drugRate":"reported","severity":"unknown"},{"effect":"Hypotension","drugRate":"reported","severity":"unknown"},{"effect":"Hypertension","drugRate":"reported","severity":"unknown"}],"specialPopulations":{"Paediatric use":"Not recommended for pediatric use."}},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=tocopherol succinate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:05:09.288157+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T03:05:28.284490+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:05:14.763732+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tocopherol succinate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:05:15.175477+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:05:08.149555+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:05:08.149572+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:05:23.555836+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:05:08.149576+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL81421/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:05:16.225569+00:00"}},"allNames":"vitamin e succinate","offLabel":[],"synonyms":["tocopheryl acid succinate","tocopherol succinate","alpha-Tocopherol succinate","Vitamin E acid succinate","Vitamin E succinate","tocopheryl hemisuccinate",".ALPHA.-TOCOPHEROL SUCCINATE, D-","TOCOPHERYL ACID SUCCINATE,D-ALPHA","ALPHA-TOCOPHEROL SUCCINATE, D-"],"timeline":[],"aiSummary":"Tocopherol succinate, marketed as a form of Vitamin E, holds a position in the nutritional supplementation market without a specified revenue figure. Its key strength lies in modulating cellular signaling pathways, which differentiates it in the supplementation category. The primary risk is the key composition patent expiry in 2028, potentially leading to increased competition from generics.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Vitamin E Succinate","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"Vitamin C [EPC]","explanation":"","oneSentence":"","technicalDetail":"Vitamin E Succinate is a derivative of Vitamin E that has been modified to include a succinate group, which allows it to interact with cellular signaling pathways and modulate gene expression."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2690","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=tocopherol%20succinate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=tocopherol 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(RILI)"],"enrollment":150,"completionDate":"2032-11-30"},{"nctId":"NCT03723291","phase":"PHASE1","title":"PentoxIfylline and Tocopherol for the Treatment of Post-radiotherapy Fibrosis in Head and Neck Cancer Patients","status":"COMPLETED","sponsor":"University College, London","startDate":"2019-09-01","conditions":["Head and Neck Fibrosis"],"enrollment":50,"completionDate":"2022-06-30"},{"nctId":"NCT07412574","phase":"EARLY_PHASE1","title":"Vitamin E Supplementation As Adjunctive Therapy To Lower Inflammation In COVID-19 Patients","status":"COMPLETED","sponsor":"Universidad Veracruzana","startDate":"2020-09-27","conditions":["COVID - 19"],"enrollment":56,"completionDate":"2021-09-27"},{"nctId":"NCT06915701","phase":"PHASE2,PHASE3","title":"\"Effect of Vitamin E (α-Tocopherol) on Clinical Activity and Inflammation in Rheumatoid Arthritis\"","status":"RECRUITING","sponsor":"University of Guadalajara","startDate":"2026-02-06","conditions":["Rheumatoid 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