{"id":"tobacco","rwe":[],"_fda":{"id":"9ed39c86-6061-4b0b-8691-c9d6adee55f5","set_id":"0aac4f4f-8f71-44fa-906f-2bf35afea431","openfda":{"nui":["N0000175415","M0014874","N0000009909","N0000185375","N0000175629","N0000184306","N0000185001","M0000728","M0016962"],"unii":["9N3437ZUU0","C9642I91WL","15443PR153","3D10KUA6BM","G59M7S0WS3","N94C2U587S","KPS1B1162N","6YR2608RSU"],"route":["ORAL"],"spl_id":["9ed39c86-6061-4b0b-8691-c9d6adee55f5"],"brand_name":["GLAUTARAKT"],"spl_set_id":["0aac4f4f-8f71-44fa-906f-2bf35afea431"],"package_ndc":["59469-131-10"],"product_ndc":["59469-131"],"generic_name":["GOLD TRICHLORIDE, SOLANUM DULCAMARA TOP, EUPHRASIA STRICTA, NITROGLYCERIN, HEDERA HELIX FLOWERING TWIG, RUTA GRAVEOLENS FLOWERING TOP, TOBACCO LEAF, AND CYNARA SCOLYMUS WHOLE"],"product_type":["HUMAN OTC DRUG"],"pharm_class_cs":["Nitrates [CS]","Allergens [CS]","Plant Proteins [CS]"],"pharm_class_pe":["Vasodilation [PE]","Increased Histamine Release [PE]","Cell-mediated Immunity [PE]","Increased IgG Production [PE]"],"substance_name":["CYNARA SCOLYMUS WHOLE","EUPHRASIA STRICTA","GOLD TRICHLORIDE","HEDERA HELIX FLOWERING TWIG","NITROGLYCERIN","RUTA GRAVEOLENS FLOWERING TOP","SOLANUM DULCAMARA TOP","TOBACCO LEAF"],"pharm_class_epc":["Nitrate Vasodilator [EPC]","Non-Standardized Plant Allergenic Extract [EPC]"],"manufacturer_name":["PEKANA Naturheilmittel GmbH"],"is_original_packager":[true]},"purpose":["For relief of occasional overexertion of the eyes. Application of this homeopathic remedy for the designated usage is exclusively based on homeopathic experience. With severe forms of this disease, a clinically proven therapy is indicated."],"version":"5","warnings":["Warning If symptoms persist, contact a licensed practitioner. If you have known sensitivity to any of the ingredients, please consult your licensed practitioner before use. If you are pregnant or nursing a baby, seek the advice of a health care professional before use. Keep out of the reach of children. Protect from light and heat. Tamper Evident Do not use this product if tamper evident strip is broken or removed from base of cap."],"questions":["To report adverse events, contact BioResource at 321B Blodgett Street, Cotati, CA 94931"],"ask_doctor":["If symptoms persist, contact a licensed practitioner. If you have known sensitivity to any of the ingredients, please consult your licensed practitioner before use. If you are pregnant or nursing a baby, seek the advice of a health care professional before use."],"effective_time":"20221215","active_ingredient":["Ingredients: Aurum chloratum 6X Cynara scolymus 8X Euphrasia officinalis 2X Nitroglycerinum (Glonoinum) 6X Hedera helix 8X Nicotiana tabacum 6X Ruta graveolens 6X Solanum dulcamara (Dulcamara) 3X Selected ingredients prepared by spagyric processes."],"inactive_ingredient":["Contains 20% alcohol by volume."],"storage_and_handling":["Protect from light and heat."],"indications_and_usage":["Indications For relief of occasional overexertion of the eyes. Application of this homeopathic remedy for the designated usage is exclusively based on homeopathic experience. With severe forms of this disease, a clinically proven therapy is indicated."],"active_ingredient_table":["<table width=\"80%\"><col width=\"85%\" align=\"left\" valign=\"middle\"/><col width=\"15%\" align=\"right\" valign=\"middle\"/><thead><tr><th colspan=\"2\">Ingredients:</th></tr></thead><tbody><tr><td>Aurum chloratum</td><td>6X</td></tr><tr><td>Cynara scolymus</td><td>8X</td></tr><tr><td>Euphrasia officinalis</td><td>2X</td></tr><tr><td>Nitroglycerinum (Glonoinum)</td><td>6X</td></tr><tr><td>Hedera helix</td><td>8X</td></tr><tr><td>Nicotiana tabacum</td><td>6X</td></tr><tr><td>Ruta graveolens</td><td>6X</td></tr><tr><td>Solanum dulcamara (Dulcamara)</td><td>3X</td></tr></tbody></table>"],"spl_unclassified_section":["Distributed by: BioResource Inc. Cotati, CA 94931 Manufactured by: PEKANA ® GmbH D-88353 Kisslegg"],"dosage_and_administration":["Dosage Unless otherwise prescribed, adults take 15-20 drops, 3 times per day. For pediatric dosages, consult your practitioner."],"spl_product_data_elements":["GLAUTARAKT Gold Trichloride, Solanum dulcamara Top, Euphrasia Stricta, Nitroglycerin, Hedera helix Flowering Twig, Ruta graveolens Flowering Top, Tobacco Leaf, and Cynara scolymus Whole Gold Trichloride Gold Cation (3+) Solanum dulcamara Top Solanum Dulcamara Top Euphrasia Stricta Euphrasia Stricta Nitroglycerin Nitroglycerin Hedera helix Flowering Twig Hedera helix Flowering Twig Ruta graveolens Flowering Top Ruta graveolens Flowering Top Tobacco Leaf Tobacco Leaf Cynara scolymus Whole Cynara Scolymus Whole Water Alcohol"],"keep_out_of_reach_of_children":["Keep out of the reach of children."],"package_label_principal_display_panel":["PRINCIPAL DISPLAY PANEL - 50 ml Bottle Box GLAUTARAKT ™ Oral Drops Homeopathic Medicine For relief of occasional overexertion of the eyes For Oral Use Only Do Not Put In Eyes 1.7 FL OZ (50 ml) PEKANA ® PRINCIPAL DISPLAY PANEL - 50 ml Bottle Box"]},"tags":[],"safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DRUG ABUSE","source":"FDA FAERS","actionTaken":"155 reports"},{"date":"","signal":"DRUG DEPENDENCE","source":"FDA FAERS","actionTaken":"39 reports"},{"date":"","signal":"TACHYCARDIA","source":"FDA FAERS","actionTaken":"37 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"35 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"34 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"33 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"32 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"31 reports"},{"date":"","signal":"ANXIETY","source":"FDA FAERS","actionTaken":"30 reports"},{"date":"","signal":"WITHDRAWAL SYNDROME","source":"FDA FAERS","actionTaken":"30 reports"}]},"trials":[],"_chembl":null,"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=Tobacco","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T02:20:37.905460+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T02:21:13.444496+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T02:20:45.179642+00:00"},"mechanism.drugClass":{"url":"https://api.fda.gov/drug/label.json","method":"deterministic","source":"FDA Label (EPC)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:20:35.653983+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:20:35.654042+00:00"},"indications.approved":{"url":"","method":"ai_extraction","source":"FDA Label + AI","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:21:08.247932+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T02:20:35.654056+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T02:21:02.542219+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL46730/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T02:21:01.445475+00:00"}},"offLabel":[],"timeline":[],"_dailymed":{"setId":"5f5b3d53-bfd8-4f74-8ee5-8b8b35f7f97e","title":"NAUSEA VOMITING HP (ARSENIC TRIOXIDE, ANAMIRTA COCCULUS SEED, IPECA, WOOD CREASOTE, KEROSENE, PULSATILLA VULGARIS, SANGUINARIA CANDENSIS ROOT, TOBACCO LEAF) LIQUID [NATURAL CREATIONS, INC.]"},"aiSummary":"Tobacco is a common name for several plants in the genus Nicotiana, primarily referring to the cured leaves of Nicotiana tabacum. It is a small molecule with the synonyms NSC-26256, PHENANTHRENE, and RAVATITE.","ecosystem":[],"mechanism":{"drugClass":"Nitrate Vasodilator [EPC]"},"_scrapedAt":"2026-03-28T06:29:01.592Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"references":[],"_validation":{"fieldsValidated":2,"lastValidatedAt":"2026-04-20T02:21:13.444977+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"indications":{"approved":[{"id":"tobacco-relief-of-occasional-eye-overe","name":"Relief of occasional eye overexertion","dosing":null,"approvals":[],"diseaseId":"","eligibility":"Not specified","pivotalTrial":null,"restrictions":[],"patientPopulation":"Not specified","diagnosticRequired":null,"brandNameForIndication":""}]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06356610","phase":"NA","title":"Pharmacokinetic and Subjective Effects of Heated Tobacco Products","status":"COMPLETED","sponsor":"Altria Client Services LLC","startDate":"2024-02-06","conditions":"Tobacco Use","enrollment":80},{"nctId":"NCT01036685","phase":"","title":"Cognitive Task Development and Implementation for Functional MRI Studies","status":"COMPLETED","sponsor":"National Institute on Drug Abuse (NIDA)","startDate":"2005-05-22","conditions":"Drug Abuse, Nicotine Dependence","enrollment":525},{"nctId":"NCT05460676","phase":"NA","title":"Reducing Tobacco Smoking: a Transcranial Direct Current Stimulation (TDCS) Telehealth Study","status":"RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2023-08-15","conditions":"Smoking Cessation","enrollment":46},{"nctId":"NCT04971954","phase":"NA","title":"Using Nicotine to Reverse Age-related Auditory Processing Deficits","status":"RECRUITING","sponsor":"University of California, Irvine","startDate":"2022-02-01","conditions":"Auditory Perceptual Impairment, Aging","enrollment":48},{"nctId":"NCT05121051","phase":"PHASE2","title":"Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers","status":"RECRUITING","sponsor":"National Cancer Institute (NCI)","startDate":"2022-09-21","conditions":"Cigarette Smoking-Related Carcinoma","enrollment":135},{"nctId":"NCT05004662","phase":"NA","title":"Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers","status":"COMPLETED","sponsor":"H. 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