{"id":"tnk-tpa","safety":{"commonSideEffects":[{"rate":null,"effect":"Bleeding (major and minor)"},{"rate":null,"effect":"Intracranial hemorrhage"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Arrhythmias"}]},"_chembl":{"chemblId":"CHEMBL454475","moleculeType":"Small molecule","molecularWeight":"843.20"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"TNK-tPA (tenecteplase) is a fibrinolytic agent derived from natural tissue plasminogen activator (tPA) with amino acid substitutions that improve its pharmacokinetic properties. It binds to fibrin in thrombi and catalyzes the conversion of plasminogen to plasmin, which degrades the fibrin matrix and dissolves the clot. The modifications make it more fibrin-specific and resistant to plasminogen activator inhibitor-1 compared to wild-type tPA, allowing for faster administration and improved efficacy.","oneSentence":"TNK-tPA is a genetically engineered tissue plasminogen activator that converts plasminogen to plasmin to dissolve blood clots.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:39:00.536Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute myocardial infarction (AMI)"},{"name":"Acute ischemic stroke"}]},"trialDetails":[{"nctId":"NCT07471256","phase":"PHASE3","title":"Neuronavigation-assisted Stereotactic Minimally Invasive Puncture With Tenecteplase for Acute Lobar Intracerebral Hemorrhage","status":"NOT_YET_RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-31","conditions":"Intracerebral Hemorrhage Lobar","enrollment":636},{"nctId":"NCT07294209","phase":"PHASE4","title":"Low-Dose Tenecteplase for Acute Ischemic Stroke 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