{"id":"tlk286-hcl-for-injection","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Neutropenia"},{"rate":"20-40%","effect":"Thrombocytopenia"},{"rate":"20-40%","effect":"Anemia"},{"rate":"10-30%","effect":"Fatigue"},{"rate":"10-30%","effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"It works by inhibiting the 20S proteasome, a protein complex involved in protein degradation. This leads to an accumulation of defective proteins, which can trigger cell death in cancer cells.","oneSentence":"TLK286 HCl for injection is a proteasome inhibitor.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:39:07.279Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Multiple myeloma"}]},"trialDetails":[{"nctId":"NCT01148108","phase":"PHASE2","title":"Study of Canfosfamide in Refractory or Relapsed Mantle Cell, Diffuse Large B Cell Lymphoma and Multiple Myeloma","status":"COMPLETED","sponsor":"Telik","startDate":"2010-06","conditions":"Mantle Cell Lymphoma, B Cell Lymphoma, Multiple Myeloma","enrollment":14},{"nctId":"NCT00057720","phase":"PHASE3","title":"TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer","status":"COMPLETED","sponsor":"Telik","startDate":"2003-06","conditions":"Ovarian Neoplasms","enrollment":440},{"nctId":"NCT00080340","phase":"PHASE3","title":"Study of TLK286 (Telcyta) vs. Gefitinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer","status":"COMPLETED","sponsor":"Telik","startDate":"","conditions":"Non Small Cell Lung Carcinoma","enrollment":520}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"TLK286 HCl for injection","genericName":"TLK286 HCl for injection","companyName":"Telik","companyId":"telik","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TLK286 HCl for injection is a medication used to treat various types of cancer, including ovarian neoplasms, mantle cell lymphoma, B cell lymphoma, multiple myeloma, and non small cell lung carcinoma. The exact mechanism of action of TLK286 HCl is unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}