{"id":"tjo-018-ha-0-15","safety":{"commonSideEffects":[{"rate":null,"effect":"Ocular irritation"},{"rate":null,"effect":"Transient blurred vision"},{"rate":null,"effect":"Eye discomfort"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Hyaluronic acid (HA) is a naturally occurring polysaccharide that acts as a humectant, binding water to maintain corneal hydration and protect the epithelial surface. At 0.15% concentration, it reduces friction between the eyelid and cornea, alleviates dry eye symptoms, and promotes corneal healing through its viscoelastic properties.","oneSentence":"TJO-018 is a hyaluronic acid-based topical formulation that provides lubrication and moisture retention to the ocular surface.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:38:52.701Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Dry eye disease / Keratoconjunctivitis sicca"}]},"trialDetails":[{"nctId":"NCT04127851","phase":"PHASE4","title":"Evaluating HA 0.15% Compared With Cyclosporine 0.05%, and Efficacy of Combination Therapy in Dry Eye Disease Patients","status":"COMPLETED","sponsor":"Taejoon Pharmaceutical Co., Ltd.","startDate":"2019-11-12","conditions":"Dry Eye, Dry Eye Syndromes","enrollment":438}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1046,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"TJO-018 (HA 0.15%)","genericName":"TJO-018 (HA 0.15%)","companyName":"Taejoon Pharmaceutical Co., Ltd.","companyId":"taejoon-pharmaceutical-co-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"TJO-018 is a hyaluronic acid-based topical formulation that provides lubrication and moisture retention to the ocular surface. Used for Dry eye disease / Keratoconjunctivitis sicca.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}