{"id":"tioxolone","rwe":[],"tags":[{"label":"tioxolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Carbonic anhydrase 2","category":"target"},{"label":"CA2","category":"gene"},{"label":"MAOB","category":"gene"},{"label":"MAOA","category":"gene"},{"label":"D10AB03","category":"atc"},{"label":"Topical","category":"route"},{"label":"Concentrate","category":"form"},{"label":"Cream","category":"form"},{"label":"Lotion","category":"form"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"camyna","offLabel":[],"synonyms":["acnosan","camyna","thidoxol","thioxolon","thioxolone","tioxolon","tioxolone"],"timeline":[],"aiSummary":"Camyna is a small molecule with the synonyms TIOXOLONA, TIOXOLONE, and TIOXOLONE.","approvals":[],"brandName":"Camyna","ecosystem":[],"mechanism":{"target":"Amine oxidase [flavin-containing] A, Amine oxidase [flavin-containing] B, Carbonic anhydrase 2","targets":[{"gene":"CA2","source":"DrugCentral","target":"Carbonic anhydrase 2","protein":"Carbonic anhydrase 2"},{"gene":"MAOB","source":"DrugCentral","target":"Amine oxidase [flavin-containing] B","protein":"Amine oxidase [flavin-containing] B"},{"gene":"MAOA","source":"DrugCentral","target":"Amine oxidase [flavin-containing] A","protein":"Amine oxidase [flavin-containing] A"}],"modality":"Small Molecule","drugClass":"tioxolone","explanation":"Think of it like a leaky faucet - carbonic anhydrase 2 helps control how much acid flows into the body's cells. When Camyna blocks this enzyme, it can help reduce the amount of acid that builds up, which can be beneficial for people with certain conditions. This can help alleviate symptoms such as pain and swelling.","oneSentence":"Camyna works by inhibiting the enzyme carbonic anhydrase 2, which helps regulate the balance of acid and base in the body.","technicalDetail":"Camyna exerts its effects by competitively inhibiting the zinc-dependent catalytic activity of carbonic anhydrase 2, thereby reducing the enzyme's ability to catalyze the reversible hydration of carbon dioxide to bicarbonate and protons."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3607","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TIOXOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T16:00:36.521464","biosimilars":[],"competitors":[{"drugName":"sulfur","drugSlug":"sulfur","fdaApproval":"1940-09-17","patentStatus":"Unknown","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"tioxolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"sulfur","brandName":"sulfur","genericName":"sulfur","approvalYear":"1940","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Concentrate, Cream, Lotion","formulations":[{"form":"CONCENTRATE","route":"TOPICAL","productName":"Anubis Barcelona"},{"form":"CONCENTRATE","route":"TOPICAL","productName":"Anubis Barcelona Regul OIl"},{"form":"CREAM","route":"TOPICAL","productName":"Anubis Barcelona Regul Oil"},{"form":"LOTION","route":"TOPICAL","productName":"Anubis Barcelona Regul Oil"}]},"crossReferences":{"NDDF":"007419","UNII":"S0FAJ1R9CD","CHEBI":"CHEBI:568021","INN_ID":"2002","RXNORM":"2059173","UMLSCUI":"C2699951","ChEMBL_ID":"CHEMBL442687","KEGG_DRUG":"D07211","DRUGBANK_ID":"DB13343","PDB_CHEM_ID":"VUO","PUBCHEM_CID":"72139","MESH_SUPPLEMENTAL_RECORD_UI":"C009474"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Pain"],"atcClassification":{"source":"DrugCentral","atcCode":"D10AB03","allCodes":["D10AB03"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}