{"id":"tiotropium-spirivatm","safety":{"commonSideEffects":[{"rate":"5–15%","effect":"Dry mouth"},{"rate":"2–5%","effect":"Tremor"},{"rate":"2–4%","effect":"Headache"},{"rate":"2–3%","effect":"Sinusitis"},{"rate":"1–2%","effect":"Urinary retention"}]},"_chembl":{"chemblId":"CHEMBL3545181","moleculeType":"Small molecule","molecularWeight":"490.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tiotropium binds to muscarinic M3 receptors on airway smooth muscle cells, preventing acetylcholine-induced bronchoconstriction. This produces a prolonged bronchodilatory effect lasting 24 hours or more, allowing once-daily dosing. The drug is delivered via inhalation directly to the lungs, minimizing systemic exposure.","oneSentence":"Tiotropium is a long-acting anticholinergic (muscarinic antagonist) that blocks M3 receptors on airway smooth muscle to produce sustained bronchodilation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:12:48.434Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic obstructive pulmonary disease (COPD) maintenance treatment"},{"name":"Asthma (in combination with inhaled corticosteroids)"}]},"trialDetails":[{"nctId":"NCT01397890","phase":"PHASE4","title":"Efficacy and Tolerability of Symbicort as an add-on Treatment to Spiriva Compare With Spiriva Alone in Patients With Severe Chronic Obstructive Pulmonary Disease (COPD)","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2011-07","conditions":"Chronic Obstructive Pulmonary Disease (COPD)","enrollment":793}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tiotropium (SpirivaTM)","genericName":"Tiotropium (SpirivaTM)","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tiotropium (SpirivaTM) is a medication used to treat Chronic Obstructive Pulmonary Disease (COPD). It is a bronchodilator that works by blocking the action of acetylcholine at muscarinic receptors in the lungs, as indicated by its listing in ChEMBL.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}