{"id":"tinoridine","rwe":[{"pmid":"38806104","year":"2024","title":"Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.","finding":"","journal":"Free radical biology & medicine","studyType":"Clinical Study"},{"pmid":"34619000","year":"2022","title":"Comprehensive degradation profiling and influence of different oxidizing reagents on tinoridine hydrochloride: Structural characterization of its degradation products using HPLC and HRMS.","finding":"","journal":"Rapid communications in mass spectrometry : RCM","studyType":"Clinical Study"},{"pmid":"34358118","year":"2021","title":"Thiophene-Based Compounds with Potential Anti-Inflammatory Activity.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"26505767","year":"2015","title":"Rapid structural characterization of in vivo and in vitro metabolites of tinoridine using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites.","finding":"","journal":"Journal of mass spectrometry : JMS","studyType":"Clinical Study"},{"pmid":"2914545","year":"1989","title":"Effects of mepirizole and basic antiinflammatory drugs on HCl-ethanol-induced gastric lesions in rats.","finding":"","journal":"Digestive diseases and sciences","studyType":"Clinical Study"}],"tags":[{"label":"tinoridine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Adenosine receptor A1","category":"target"},{"label":"ADORA1","category":"gene"},{"label":"Active","category":"status"},{"label":"Pain","category":"indication"},{"label":"Analgesics","category":"pharmacology"},{"label":"Analgesics, Non-Narcotic","category":"pharmacology"},{"label":"Anti-Inflammatory Agents","category":"pharmacology"},{"label":"Anti-Inflammatory Agents, Non-Steroidal","category":"pharmacology"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sensory System Agents","category":"pharmacology"}],"phase":"phase_3","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tienoridine","offLabel":[],"synonyms":["tinoridine hydrochloride","tienoridine","tienoridine hydrochloride","tinoridine","tinoridine HCl","tienoridine HCl"],"timeline":[],"approvals":[],"brandName":"Tienoridine","ecosystem":[{"indication":"Pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"bromfenac","slug":"bromfenac","company":"Bausch And Lomb Inc"},{"name":"butorphanol","slug":"butorphanol","company":""},{"name":"caffeine","slug":"caffeine","company":"Novartis"}],"globalPrevalence":1500000000}],"mechanism":{"target":"Adenosine receptor A1","targets":[{"gene":"ADORA1","source":"DrugCentral","target":"Adenosine receptor A1","protein":"Adenosine receptor A1"}],"modality":"Small Molecule","drugClass":"tinoridine","explanation":"Imagine your brain is like a busy city, and the adenosine receptor A1 is like a traffic light that helps control the flow of information between different parts of the city. When Tienoridine binds to this receptor, it helps to slow down the flow of pain signals, making it easier to manage pain. This can be especially helpful for people who are experiencing chronic pain.","oneSentence":"Tienoridine works by binding to the adenosine receptor A1, which helps to reduce pain by modulating the activity of neurons.","technicalDetail":"Tienoridine acts as a selective agonist of the adenosine receptor A1, which is involved in the regulation of pain perception and modulation of neuronal activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2672","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=TINORIDINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TINORIDINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:57:07.871868","biosimilars":[],"competitors":[{"drugName":"adenosine","drugSlug":"adenosine","fdaApproval":"1989-10-30","genericCount":15,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"caffeine","drugSlug":"caffeine","fdaApproval":"1948-11-26","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"choline 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theophyllinate","approvalYear":"1981","relationship":"same-target"},{"drugId":"clotrimazole","brandName":"clotrimazole","genericName":"clotrimazole","approvalYear":"1975","relationship":"same-target"},{"drugId":"diethylstilbestrol","brandName":"diethylstilbestrol","genericName":"diethylstilbestrol","approvalYear":"1973","relationship":"same-target"},{"drugId":"econazole","brandName":"econazole","genericName":"econazole","approvalYear":"1982","relationship":"same-target"},{"drugId":"gabapentin","brandName":"gabapentin","genericName":"gabapentin","approvalYear":"1993","relationship":"same-target"},{"drugId":"istradefylline","brandName":"istradefylline","genericName":"istradefylline","approvalYear":"2019","relationship":"same-target"},{"drugId":"liothyronine","brandName":"liothyronine","genericName":"liothyronine","approvalYear":"1956","relationship":"same-target"},{"drugId":"lovastatin","brandName":"lovastatin","genericName":"lovastatin","approvalYear":"1987","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT01224756","phase":"PHASE4","title":"Efficacy of Tinoridine in Treating Pain and Inflammation in Adults","status":"COMPLETED","sponsor":"Takeda","startDate":"2010-11","conditions":["Pain","Inflammation"],"enrollment":342,"completionDate":"2011-10"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"C9Z9ICZ7YR","CHEBI":"CHEBI:32228","INN_ID":"3079","UMLSCUI":"C0076703","ChEMBL_ID":"CHEMBL592943","KEGG_DRUG":"D01484","DRUGBANK_ID":"DB13001","PUBCHEM_CID":"5480","SECONDARY_CAS_RN":"25913-34-2","MESH_SUPPLEMENTAL_RECORD_UI":"C100290"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Aug 20","pmid":"38806104","title":"Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy.","journal":"Free radical biology & medicine"},{"date":"2022 Jan 15","pmid":"34619000","title":"Comprehensive degradation profiling and influence of different oxidizing reagents on tinoridine hydrochloride: Structural characterization of its degradation products using HPLC and HRMS.","journal":"Rapid communications in mass spectrometry : RCM"},{"date":"2021 Jul 19","pmid":"34358118","title":"Thiophene-Based Compounds with Potential Anti-Inflammatory Activity.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2015 Nov","pmid":"26505767","title":"Rapid structural characterization of in vivo and in vitro metabolites of tinoridine using UHPLC-QTOF-MS/MS and in silico toxicological screening of its metabolites.","journal":"Journal of mass spectrometry : JMS"},{"date":"1989 Feb","pmid":"2914545","title":"Effects of mepirizole and basic antiinflammatory drugs on HCl-ethanol-induced gastric lesions in rats.","journal":"Digestive diseases and sciences"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tienoridine is a small molecule with the synonyms NSC-158555, TINORIDINA, TINORIDINE, TINORIDINE, Y 3642, and Y-3642.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}