{"id":"tinidazole-fluconazole-vs-metronidazole-clotrimazole","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Diarrhea"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Abdominal pain"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Tinidazole is a nitroimidazole antibiotic that inhibits DNA synthesis by binding to DNA and causing cross-linking, ultimately leading to cell death. Fluconazole is an azole antifungal that inhibits the synthesis of ergosterol, an essential component of fungal cell membranes, by binding to the enzyme lanosterol 14α-demethylase.","oneSentence":"Tinidazole and fluconazole work by inhibiting the synthesis of DNA and RNA in susceptible fungi and bacteria, respectively.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:54:12.033Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Bacterial vaginosis"},{"name":"Vaginal candidiasis"}]},"trialDetails":[{"nctId":"NCT00313131","phase":"PHASE3","title":"Study of the Management of Vaginal Discharge in West African Using Single Dose Treatments","status":"COMPLETED","sponsor":"Université de Sherbrooke","startDate":"2004-01","conditions":"Bacterial Vaginosis, Candidiasis, Vaginitis","enrollment":1524}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"tinidazole+fluconazole vs metronidazole+clotrimazole","genericName":"tinidazole+fluconazole vs metronidazole+clotrimazole","companyName":"Université de Sherbrooke","companyId":"universit-de-sherbrooke","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tinidazole and fluconazole work by inhibiting the synthesis of DNA and RNA in susceptible fungi and bacteria, respectively. Used for Bacterial vaginosis, Vaginal candidiasis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}