{"id":"tilisolol","rwe":[],"tags":[{"label":"tilisolol","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Angina pectoris","category":"indication"},{"label":"Essential hypertension","category":"indication"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Antagonists","category":"pharmacology"},{"label":"Adrenergic beta-Antagonists","category":"pharmacology"},{"label":"Anti-Arrhythmia Agents","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"selecal","offLabel":[],"synonyms":["selecal","tilisolol","tilisolol hydrochloride","tilisolol HCl"],"timeline":[],"approvals":[],"brandName":"Selecal","ecosystem":[{"indication":"Angina pectoris","otherDrugs":[{"name":"amlodipine","slug":"amlodipine","company":"Pfizer"},{"name":"atenolol","slug":"atenolol","company":"Alvogen Ipco Sarl"},{"name":"atorvastatin","slug":"atorvastatin","company":"Pfizer"},{"name":"bepridil","slug":"bepridil","company":""}],"globalPrevalence":112000000},{"indication":"Essential hypertension","otherDrugs":[{"name":"alacepril","slug":"alacepril","company":"Par Pharm"}],"globalPrevalence":1280000000}],"mechanism":{"modality":"Small Molecule","drugClass":"tilisolol","explanation":"Imagine your heart is like a racing car engine. Beta-1 adrenergic receptors are like the accelerator pedal, making the engine go faster. By blocking these receptors, Selecal helps slow down the heart rate and reduce blood pressure, making it easier for the heart to pump blood and reducing symptoms of angina and hypertension.","oneSentence":"Selecal works by blocking beta-1 adrenergic receptors in the heart, reducing heart rate and blood pressure.","technicalDetail":"Selecal exerts its effects by selectively antagonizing beta-1 adrenergic receptors, which are primarily located in the heart, thereby reducing heart rate and contractility."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2665","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=TILISOLOL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:55:08.728285","biosimilars":[],"competitors":[],"genericName":"tilisolol","indications":{"approved":[{"name":"Angina pectoris","source":"DrugCentral","snomedId":194828000,"regulator":"FDA","usPrevalence":null,"globalPrevalence":112000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"},{"name":"Essential hypertension","source":"DrugCentral","snomedId":59621000,"regulator":"FDA","usPrevalence":119900000,"globalPrevalence":1280000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"QUF41MF56G","CHEBI":"CHEBI:135291","INN_ID":"6063","UMLSCUI":"C0076678","ChEMBL_ID":"CHEMBL1742457","KEGG_DRUG":"D01795","PUBCHEM_CID":"5474","SECONDARY_CAS_RN":"62774-96-3","MESH_SUPPLEMENTAL_RECORD_UI":"C036593"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":24,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Selecal (Tilisolol) is a small molecule drug in the tilisolol class, used to treat Angina pectoris and Essential hypertension. Its commercial status is unknown, but it is used to manage cardiovascular conditions. As a tilisolol, Selecal works by blocking beta-1 adrenergic receptors, which helps to reduce heart rate and blood pressure. This results in improved blood flow to the heart, reducing symptoms of angina and hypertension. However, more information is needed to fully understand its pharmacological profile.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}