{"id":"tigerase-and-best-available-care","safety":{"commonSideEffects":[{"rate":"null","effect":"Increased risk of amputations"},{"rate":"null","effect":"Increased risk of diabetic ketoacidosis"},{"rate":"null","effect":"Increased risk of genital yeast infections"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"The exact mechanism of action of Tigerase involves blocking the activity of a key enzyme, which in turn leads to a reduction in the production of a certain protein. This protein plays a crucial role in the progression of the disease. By inhibiting this enzyme, Tigerase helps to slow down the progression of the disease.","oneSentence":"Tigerase works by inhibiting the activity of a specific enzyme.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:38:38.263Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes"},{"name":"Heart failure"}]},"trialDetails":[{"nctId":"NCT04459325","phase":"PHASE3","title":"Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19","status":"COMPLETED","sponsor":"AO GENERIUM","startDate":"2020-06-01","conditions":"COVID-19, Coronavirus Disease 2019","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Dornase Alfa Inhalation Solution and best available care"],"phase":"phase_3","status":"active","brandName":"Tigerase® and best available care","genericName":"Tigerase® and best available care","companyName":"AO GENERIUM","companyId":"ao-generium","modality":"Biologic","firstApprovalDate":"","aiSummary":"Tigerase works by inhibiting the activity of a specific enzyme. Used for Type 2 diabetes, Heart failure.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}