{"id":"ticlopidine-and-itraconazole","safety":{"commonSideEffects":[{"rate":null,"effect":"Neutropenia (ticlopidine)"},{"rate":null,"effect":"Thrombotic thrombocytopenic purpura (ticlopidine)"},{"rate":null,"effect":"Nausea (itraconazole)"},{"rate":null,"effect":"Hepatotoxicity (itraconazole)"},{"rate":null,"effect":"Drug-drug interactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ticlopidine inhibits platelet aggregation by blocking ADP-induced platelet activation, reducing thrombotic events. Itraconazole is a triazole antifungal that inhibits fungal cytochrome P450-dependent lanosterol demethylase, preventing ergosterol synthesis. The combination addresses both antiplatelet and antifungal therapeutic needs, though this pairing is unusual and likely reflects a specific clinical scenario rather than a synergistic mechanism.","oneSentence":"This is a combination of ticlopidine (a platelet aggregation inhibitor) and itraconazole (an antifungal agent), used together to manage thrombotic and fungal complications.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:12:44.255Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Thrombotic prevention (ticlopidine component)"},{"name":"Fungal infection treatment (itraconazole component)"}]},"trialDetails":[{"nctId":"NCT01214941","phase":"PHASE4","title":"Effect of Itraconazole and Ticlopidine on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol","status":"COMPLETED","sponsor":"Turku University Hospital","startDate":"2010-09","conditions":"Pharmacokinetics, Pharmacodynamics","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Ticlopidine and itraconazole","genericName":"Ticlopidine and itraconazole","companyName":"Turku University Hospital","companyId":"turku-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of ticlopidine (a platelet aggregation inhibitor) and itraconazole (an antifungal agent), used together to manage thrombotic and fungal complications. Used for Thrombotic prevention (ticlopidine component), Fungal infection treatment (itraconazole component).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}